Population Pharmacokinetics of Continuous-Infusion Meropenem in Febrile Neutropenic Patients with Hematologic Malignancies: Dosing Strategies for Optimizing Empirical Treatment against Enterobacterales and <i>P. aeruginosa</i>

Population Pharmacokinetics of Continuous-Infusion Meropenem in Febrile Neutropenic Patients with Hematologic Malignancies: Dosing Strategies for Optimizing Empirical Treatment against Enterobacterales and <i>P. aeruginosa</i>

A population pharmacokinetic analysis of continuous infusion (CI) meropenem was conducted in a prospective cohort of febrile neutropenic (FN) patients with hematologic malignancies. A non-parametric approach with Pmetrics was used for pharmacokinetic analysis and covariate evaluation. Monte Carlo si...

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Bibliographic Details
Main Authors: Pier Giorgio Cojutti, Anna Candoni, Davide Lazzarotto, Carla Filì, Maria Zannier, Renato Fanin, Federico Pea
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Pharmaceutics
Subjects:
continuous-infusion meropenem
patients with hematologic malignancies
population pharmacokinetics
Online Access:https://www.mdpi.com/1999-4923/12/9/785

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