Iron Complexes of Flavonoids-Antioxidant Capacity and Beyond
Flavonoids are common plant natural products able to suppress ROS-related damage and alleviate oxidative stress. One of key mechanisms, involved in this phenomenon is chelation of transition metal ions. From a physiological perspective, iron is the most significant transition metal, because of its a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/2/646 |
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| author | Zdeněk Kejík Robert Kaplánek Michal Masařík Petr Babula Adam Matkowski Petr Filipenský Kateřina Veselá Jakub Gburek David Sýkora Pavel Martásek Milan Jakubek |
| author_facet | Zdeněk Kejík Robert Kaplánek Michal Masařík Petr Babula Adam Matkowski Petr Filipenský Kateřina Veselá Jakub Gburek David Sýkora Pavel Martásek Milan Jakubek |
| author_sort | Zdeněk Kejík |
| collection | DOAJ |
| description | Flavonoids are common plant natural products able to suppress ROS-related damage and alleviate oxidative stress. One of key mechanisms, involved in this phenomenon is chelation of transition metal ions. From a physiological perspective, iron is the most significant transition metal, because of its abundance in living organisms and ubiquitous involvement in redox processes. The chemical, pharmaceutical, and biological properties of flavonoids can be significantly affected by their interaction with transition metal ions, mainly iron. In this review, we explain the interaction of various flavonoid structures with Fe(II) and Fe(III) ions and critically discuss the influence of chelated ions on the flavonoid biochemical properties. In addition, specific biological effects of their iron metallocomplexes, such as the inhibition of iron-containing enzymes, have been included in this review. |
| first_indexed | 2024-03-09T05:16:04Z |
| format | Article |
| id | doaj.art-7e5a9e9d32c44ec7b2655ce5a8e14e7a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T05:16:04Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-7e5a9e9d32c44ec7b2655ce5a8e14e7a2023-12-03T12:45:36ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-01-0122264610.3390/ijms22020646Iron Complexes of Flavonoids-Antioxidant Capacity and BeyondZdeněk Kejík0Robert Kaplánek1Michal Masařík2Petr Babula3Adam Matkowski4Petr Filipenský5Kateřina Veselá6Jakub Gburek7David Sýkora8Pavel Martásek9Milan Jakubek10Department of Paediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University and General University Hospital in Prague, CZ-121 08 Prague, Czech RepublicDepartment of Paediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University and General University Hospital in Prague, CZ-121 08 Prague, Czech RepublicDepartment of Paediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University and General University Hospital in Prague, CZ-121 08 Prague, Czech RepublicDepartment of Physiology, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech RepublicDepartment of Pharmaceutical Biology and Botany, Wroclaw Medical University, Borowska 211, 50556 Wroclaw, PolandDepartment of Urology, St. Anne’s University Hospital Brno, Pekařská 53, 656 91 Brno, Czech RepublicDepartment of Paediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University and General University Hospital in Prague, CZ-121 08 Prague, Czech RepublicDepartment of Pharmaceutical Biochemistry, Wroclaw Medical University, Borowska 211A, 50556 Wroclaw, PolandDepartment of Paediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University and General University Hospital in Prague, CZ-121 08 Prague, Czech RepublicDepartment of Paediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University and General University Hospital in Prague, CZ-121 08 Prague, Czech RepublicDepartment of Paediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University and General University Hospital in Prague, CZ-121 08 Prague, Czech RepublicFlavonoids are common plant natural products able to suppress ROS-related damage and alleviate oxidative stress. One of key mechanisms, involved in this phenomenon is chelation of transition metal ions. From a physiological perspective, iron is the most significant transition metal, because of its abundance in living organisms and ubiquitous involvement in redox processes. The chemical, pharmaceutical, and biological properties of flavonoids can be significantly affected by their interaction with transition metal ions, mainly iron. In this review, we explain the interaction of various flavonoid structures with Fe(II) and Fe(III) ions and critically discuss the influence of chelated ions on the flavonoid biochemical properties. In addition, specific biological effects of their iron metallocomplexes, such as the inhibition of iron-containing enzymes, have been included in this review.https://www.mdpi.com/1422-0067/22/2/646flavonoidsiron ionsmetallocomplexes |
| spellingShingle | Zdeněk Kejík Robert Kaplánek Michal Masařík Petr Babula Adam Matkowski Petr Filipenský Kateřina Veselá Jakub Gburek David Sýkora Pavel Martásek Milan Jakubek Iron Complexes of Flavonoids-Antioxidant Capacity and Beyond International Journal of Molecular Sciences flavonoids iron ions metallocomplexes |
| title | Iron Complexes of Flavonoids-Antioxidant Capacity and Beyond |
| title_full | Iron Complexes of Flavonoids-Antioxidant Capacity and Beyond |
| title_fullStr | Iron Complexes of Flavonoids-Antioxidant Capacity and Beyond |
| title_full_unstemmed | Iron Complexes of Flavonoids-Antioxidant Capacity and Beyond |
| title_short | Iron Complexes of Flavonoids-Antioxidant Capacity and Beyond |
| title_sort | iron complexes of flavonoids antioxidant capacity and beyond |
| topic | flavonoids iron ions metallocomplexes |
| url | https://www.mdpi.com/1422-0067/22/2/646 |
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