Diagnosis of Creutzfeldt-Jacob Disease on Diffusion Weighted MR Imaging Manifesting With Typical Pulvinar or Hockey Stick Sign
Creutzfeldt-Jacob disease (CJD) is a rapidly progressing fatal neurodegenerative disease and can manifest with a rapidly progressive cognitive decline, ataxia, behavioral changes, visual disturbances and myoclonus. In our case report, we described a 68-year-old woman presented with rapid cognitive...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2023-07-01
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| Series: | Acta Medica Iranica |
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| Online Access: | https://acta.tums.ac.ir/index.php/acta/article/view/8987 |
| _version_ | 1797768489686007808 |
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| author | Ahmet Mesrur Halefoglu |
| author_facet | Ahmet Mesrur Halefoglu |
| author_sort | Ahmet Mesrur Halefoglu |
| collection | DOAJ |
| description |
Creutzfeldt-Jacob disease (CJD) is a rapidly progressing fatal neurodegenerative disease and can manifest with a rapidly progressive cognitive decline, ataxia, behavioral changes, visual disturbances and myoclonus. In our case report, we described a 68-year-old woman presented with rapid cognitive decline, gait disturbance, and cerebellar symptoms. Her laboratory and CSF examinations were found within normal limits. EEG examination revealed generalized periodic sharp and slow wave complexes. She underwent MRI examination including DWI. On DWI, restricted diffusion was detected at bilateral fronto-parietal and temporo-occipital lobes involving cingulate gyrus and bilateral basal ganglia and thalamic regions. The typical bilateral restricted diffusion areas in the medial pulvinar nuclei of the medial called as pulvinar sign or hockey stick sign were also found. DWI plays a crucial role in the diagnosis of CJD, because restricted diffusion abnormalities could be detected within a couple of weeks after the onset of disease symptoms and even before the manifestation of periodic triphasic waves on EEG. Hence, in this case report, we would like to emphasize the invaluable role of DWI in the early diagnosis of CJD cases.
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| first_indexed | 2024-03-12T20:54:23Z |
| format | Article |
| id | doaj.art-7e5fd31899074d94ae0216cf60887dce |
| institution | Directory Open Access Journal |
| issn | 0044-6025 1735-9694 |
| language | English |
| last_indexed | 2024-03-12T20:54:23Z |
| publishDate | 2023-07-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj.art-7e5fd31899074d94ae0216cf60887dce2023-07-31T20:43:50ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942023-07-0161410.18502/acta.v61i4.13179Diagnosis of Creutzfeldt-Jacob Disease on Diffusion Weighted MR Imaging Manifesting With Typical Pulvinar or Hockey Stick SignAhmet Mesrur Halefoglu0Department of Radiology, Sisli Hamidiye Etfal Training and Research Hospital, University of Health Sciences, Istanbul, Turkey Creutzfeldt-Jacob disease (CJD) is a rapidly progressing fatal neurodegenerative disease and can manifest with a rapidly progressive cognitive decline, ataxia, behavioral changes, visual disturbances and myoclonus. In our case report, we described a 68-year-old woman presented with rapid cognitive decline, gait disturbance, and cerebellar symptoms. Her laboratory and CSF examinations were found within normal limits. EEG examination revealed generalized periodic sharp and slow wave complexes. She underwent MRI examination including DWI. On DWI, restricted diffusion was detected at bilateral fronto-parietal and temporo-occipital lobes involving cingulate gyrus and bilateral basal ganglia and thalamic regions. The typical bilateral restricted diffusion areas in the medial pulvinar nuclei of the medial called as pulvinar sign or hockey stick sign were also found. DWI plays a crucial role in the diagnosis of CJD, because restricted diffusion abnormalities could be detected within a couple of weeks after the onset of disease symptoms and even before the manifestation of periodic triphasic waves on EEG. Hence, in this case report, we would like to emphasize the invaluable role of DWI in the early diagnosis of CJD cases. https://acta.tums.ac.ir/index.php/acta/article/view/8987Creutzfeldt-Jacob diseaseDiffusion-weighted imagingPrionic diseaseRapidly progressing dementia |
| spellingShingle | Ahmet Mesrur Halefoglu Diagnosis of Creutzfeldt-Jacob Disease on Diffusion Weighted MR Imaging Manifesting With Typical Pulvinar or Hockey Stick Sign Acta Medica Iranica Creutzfeldt-Jacob disease Diffusion-weighted imaging Prionic disease Rapidly progressing dementia |
| title | Diagnosis of Creutzfeldt-Jacob Disease on Diffusion Weighted MR Imaging Manifesting With Typical Pulvinar or Hockey Stick Sign |
| title_full | Diagnosis of Creutzfeldt-Jacob Disease on Diffusion Weighted MR Imaging Manifesting With Typical Pulvinar or Hockey Stick Sign |
| title_fullStr | Diagnosis of Creutzfeldt-Jacob Disease on Diffusion Weighted MR Imaging Manifesting With Typical Pulvinar or Hockey Stick Sign |
| title_full_unstemmed | Diagnosis of Creutzfeldt-Jacob Disease on Diffusion Weighted MR Imaging Manifesting With Typical Pulvinar or Hockey Stick Sign |
| title_short | Diagnosis of Creutzfeldt-Jacob Disease on Diffusion Weighted MR Imaging Manifesting With Typical Pulvinar or Hockey Stick Sign |
| title_sort | diagnosis of creutzfeldt jacob disease on diffusion weighted mr imaging manifesting with typical pulvinar or hockey stick sign |
| topic | Creutzfeldt-Jacob disease Diffusion-weighted imaging Prionic disease Rapidly progressing dementia |
| url | https://acta.tums.ac.ir/index.php/acta/article/view/8987 |
| work_keys_str_mv | AT ahmetmesrurhalefoglu diagnosisofcreutzfeldtjacobdiseaseondiffusionweightedmrimagingmanifestingwithtypicalpulvinarorhockeysticksign |