Extrinsic and intrinsic factors controlling spermatogonial stem cell self-renewal and differentiation
Spermatogonial stem cells (SSCs), the stem cells responsible for male fertility, are one of a small number of cells with the abilities of both self-renewal and generation of large numbers of haploid cells. Technology improvements, most importantly, transplantation assays and in vitro culture systems...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-06-01
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| Series: | Asian Journal of Andrology |
| Subjects: | |
| Online Access: | http://ajandrology.com/article.asp?issn=1008-682X;year=2015;volume=17;issue=3;spage=347;epage=354;aulast=Mei |
| _version_ | 1818610767127117824 |
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| author | Xing-Xing Mei Jian Wang Ji Wu |
| author_facet | Xing-Xing Mei Jian Wang Ji Wu |
| author_sort | Xing-Xing Mei |
| collection | DOAJ |
| description | Spermatogonial stem cells (SSCs), the stem cells responsible for male fertility, are one of a small number of cells with the abilities of both self-renewal and generation of large numbers of haploid cells. Technology improvements, most importantly, transplantation assays and in vitro culture systems have greatly expanded our understanding of SSC self-renewal and differentiation. Many important molecules crucial for the balance between self-renewal and differentiation have been recently identified although the exact mechanism(s) remain largely undefined. In this review, we give a brief introduction to SSCs, and then focus on extrinsic and intrinsic factors controlling SSCs self-renewal and differentiation. |
| first_indexed | 2024-12-16T15:19:40Z |
| format | Article |
| id | doaj.art-7e606d10635841b1ae824538e5a4ad56 |
| institution | Directory Open Access Journal |
| issn | 1008-682X 1745-7262 |
| language | English |
| last_indexed | 2024-12-16T15:19:40Z |
| publishDate | 2015-06-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Andrology |
| spelling | doaj.art-7e606d10635841b1ae824538e5a4ad562022-12-21T22:26:41ZengWolters Kluwer Medknow PublicationsAsian Journal of Andrology1008-682X1745-72622015-06-0117334735410.4103/1008-682X.148080Extrinsic and intrinsic factors controlling spermatogonial stem cell self-renewal and differentiationXing-Xing Mei Jian WangJi WuSpermatogonial stem cells (SSCs), the stem cells responsible for male fertility, are one of a small number of cells with the abilities of both self-renewal and generation of large numbers of haploid cells. Technology improvements, most importantly, transplantation assays and in vitro culture systems have greatly expanded our understanding of SSC self-renewal and differentiation. Many important molecules crucial for the balance between self-renewal and differentiation have been recently identified although the exact mechanism(s) remain largely undefined. In this review, we give a brief introduction to SSCs, and then focus on extrinsic and intrinsic factors controlling SSCs self-renewal and differentiation.http://ajandrology.com/article.asp?issn=1008-682X;year=2015;volume=17;issue=3;spage=347;epage=354;aulast=Meidifferentiation; self-renewal; signal; spermatogonial stem cells |
| spellingShingle | Xing-Xing Mei Jian Wang Ji Wu Extrinsic and intrinsic factors controlling spermatogonial stem cell self-renewal and differentiation Asian Journal of Andrology differentiation; self-renewal; signal; spermatogonial stem cells |
| title | Extrinsic and intrinsic factors controlling spermatogonial stem cell self-renewal and differentiation |
| title_full | Extrinsic and intrinsic factors controlling spermatogonial stem cell self-renewal and differentiation |
| title_fullStr | Extrinsic and intrinsic factors controlling spermatogonial stem cell self-renewal and differentiation |
| title_full_unstemmed | Extrinsic and intrinsic factors controlling spermatogonial stem cell self-renewal and differentiation |
| title_short | Extrinsic and intrinsic factors controlling spermatogonial stem cell self-renewal and differentiation |
| title_sort | extrinsic and intrinsic factors controlling spermatogonial stem cell self renewal and differentiation |
| topic | differentiation; self-renewal; signal; spermatogonial stem cells |
| url | http://ajandrology.com/article.asp?issn=1008-682X;year=2015;volume=17;issue=3;spage=347;epage=354;aulast=Mei |
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