Exploring the role of ketone bodies in the diagnosis and treatment of psychiatric disorders
In recent times, advances in the field of metabolomics have shed greater light on the role of metabolic disturbances in neuropsychiatric conditions. The following review explores the role of ketone bodies and ketosis in both the diagnosis and treatment of three major psychiatric disorders: major dep...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1142682/full |
| _version_ | 1797845608738848768 |
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| author | Naomi Elyse Omori Mantas Kazimieras Malys Geoffrey Woo Latt Mansor |
| author_facet | Naomi Elyse Omori Mantas Kazimieras Malys Geoffrey Woo Latt Mansor |
| author_sort | Naomi Elyse Omori |
| collection | DOAJ |
| description | In recent times, advances in the field of metabolomics have shed greater light on the role of metabolic disturbances in neuropsychiatric conditions. The following review explores the role of ketone bodies and ketosis in both the diagnosis and treatment of three major psychiatric disorders: major depressive disorder, anxiety disorders, and schizophrenia. Distinction is made between the potential therapeutic effects of the ketogenic diet and exogenous ketone preparations, as exogenous ketones in particular offer a standardized, reproducible manner for inducing ketosis. Compelling associations between symptoms of mental distress and dysregulation in central nervous system ketone metabolism have been demonstrated in preclinical studies with putative neuroprotective effects of ketone bodies being elucidated, including effects on inflammasomes and the promotion of neurogenesis in the central nervous system. Despite emerging pre-clinical data, clinical research on ketone body effectiveness as a treatment option for psychiatric disorders remains lacking. This gap in understanding warrants further investigating, especially considering that safe and acceptable ways of inducing ketosis are readily available. |
| first_indexed | 2024-04-09T17:41:46Z |
| format | Article |
| id | doaj.art-7e6071dfe0c742c5937680fc2c25d232 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-09T17:41:46Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-7e6071dfe0c742c5937680fc2c25d2322023-04-17T05:00:03ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402023-04-011410.3389/fpsyt.2023.11426821142682Exploring the role of ketone bodies in the diagnosis and treatment of psychiatric disordersNaomi Elyse Omori0Mantas Kazimieras Malys1Geoffrey Woo2Latt Mansor3Health Via Modern Nutrition Inc. (H.V.M.N.), San Francisco, CA, United StatesDepartment of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King’s College, London, United KingdomHealth Via Modern Nutrition Inc. (H.V.M.N.), San Francisco, CA, United StatesHealth Via Modern Nutrition Inc. (H.V.M.N.), San Francisco, CA, United StatesIn recent times, advances in the field of metabolomics have shed greater light on the role of metabolic disturbances in neuropsychiatric conditions. The following review explores the role of ketone bodies and ketosis in both the diagnosis and treatment of three major psychiatric disorders: major depressive disorder, anxiety disorders, and schizophrenia. Distinction is made between the potential therapeutic effects of the ketogenic diet and exogenous ketone preparations, as exogenous ketones in particular offer a standardized, reproducible manner for inducing ketosis. Compelling associations between symptoms of mental distress and dysregulation in central nervous system ketone metabolism have been demonstrated in preclinical studies with putative neuroprotective effects of ketone bodies being elucidated, including effects on inflammasomes and the promotion of neurogenesis in the central nervous system. Despite emerging pre-clinical data, clinical research on ketone body effectiveness as a treatment option for psychiatric disorders remains lacking. This gap in understanding warrants further investigating, especially considering that safe and acceptable ways of inducing ketosis are readily available.https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1142682/fullketoneBHBβ-hydroxybutyric acidanxietydepressionschizophrenia |
| spellingShingle | Naomi Elyse Omori Mantas Kazimieras Malys Geoffrey Woo Latt Mansor Exploring the role of ketone bodies in the diagnosis and treatment of psychiatric disorders Frontiers in Psychiatry ketone BHB β-hydroxybutyric acid anxiety depression schizophrenia |
| title | Exploring the role of ketone bodies in the diagnosis and treatment of psychiatric disorders |
| title_full | Exploring the role of ketone bodies in the diagnosis and treatment of psychiatric disorders |
| title_fullStr | Exploring the role of ketone bodies in the diagnosis and treatment of psychiatric disorders |
| title_full_unstemmed | Exploring the role of ketone bodies in the diagnosis and treatment of psychiatric disorders |
| title_short | Exploring the role of ketone bodies in the diagnosis and treatment of psychiatric disorders |
| title_sort | exploring the role of ketone bodies in the diagnosis and treatment of psychiatric disorders |
| topic | ketone BHB β-hydroxybutyric acid anxiety depression schizophrenia |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1142682/full |
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