Sustainable Biodegradable Biopolymer-Based Nanoparticles for Healthcare Applications
Biopolymeric nanoparticles are gaining importance as nanocarriers for various biomedical applications, enabling long-term and controlled release at the target site. Since they are promising delivery systems for various therapeutic agents and offer advantageous properties such as biodegradability, bi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/4/3188 |
| _version_ | 1797620611391946752 |
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| author | Nika Kučuk Mateja Primožič Željko Knez Maja Leitgeb |
| author_facet | Nika Kučuk Mateja Primožič Željko Knez Maja Leitgeb |
| author_sort | Nika Kučuk |
| collection | DOAJ |
| description | Biopolymeric nanoparticles are gaining importance as nanocarriers for various biomedical applications, enabling long-term and controlled release at the target site. Since they are promising delivery systems for various therapeutic agents and offer advantageous properties such as biodegradability, biocompatibility, non-toxicity, and stability compared to various toxic metal nanoparticles, we decided to provide an overview on this topic. Therefore, the review focuses on the use of biopolymeric nanoparticles of animal, plant, algal, fungal, and bacterial origin as a sustainable material for potential use as drug delivery systems. A particular focus is on the encapsulation of many different therapeutic agents categorized as bioactive compounds, drugs, antibiotics, and other antimicrobial agents, extracts, and essential oils into protein- and polysaccharide-based nanocarriers. These show promising benefits for human health, especially for successful antimicrobial and anticancer activity. The review article, divided into protein-based and polysaccharide-based biopolymeric nanoparticles and further according to the origin of the biopolymer, enables the reader to select the appropriate biopolymeric nanoparticles more easily for the incorporation of the desired component. The latest research results from the last five years in the field of the successful production of biopolymeric nanoparticles loaded with various therapeutic agents for healthcare applications are included in this review. |
| first_indexed | 2024-03-11T08:44:05Z |
| format | Article |
| id | doaj.art-7e616e4fd4b245769eb5952d2b1d5f18 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T08:44:05Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-7e616e4fd4b245769eb5952d2b1d5f182023-11-16T20:56:27ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-02-01244318810.3390/ijms24043188Sustainable Biodegradable Biopolymer-Based Nanoparticles for Healthcare ApplicationsNika Kučuk0Mateja Primožič1Željko Knez2Maja Leitgeb3Faculty of Chemistry and Chemical Engineering, University of Maribor, Smetanova Ulica 17, 2000 Maribor, SloveniaFaculty of Chemistry and Chemical Engineering, University of Maribor, Smetanova Ulica 17, 2000 Maribor, SloveniaFaculty of Chemistry and Chemical Engineering, University of Maribor, Smetanova Ulica 17, 2000 Maribor, SloveniaFaculty of Chemistry and Chemical Engineering, University of Maribor, Smetanova Ulica 17, 2000 Maribor, SloveniaBiopolymeric nanoparticles are gaining importance as nanocarriers for various biomedical applications, enabling long-term and controlled release at the target site. Since they are promising delivery systems for various therapeutic agents and offer advantageous properties such as biodegradability, biocompatibility, non-toxicity, and stability compared to various toxic metal nanoparticles, we decided to provide an overview on this topic. Therefore, the review focuses on the use of biopolymeric nanoparticles of animal, plant, algal, fungal, and bacterial origin as a sustainable material for potential use as drug delivery systems. A particular focus is on the encapsulation of many different therapeutic agents categorized as bioactive compounds, drugs, antibiotics, and other antimicrobial agents, extracts, and essential oils into protein- and polysaccharide-based nanocarriers. These show promising benefits for human health, especially for successful antimicrobial and anticancer activity. The review article, divided into protein-based and polysaccharide-based biopolymeric nanoparticles and further according to the origin of the biopolymer, enables the reader to select the appropriate biopolymeric nanoparticles more easily for the incorporation of the desired component. The latest research results from the last five years in the field of the successful production of biopolymeric nanoparticles loaded with various therapeutic agents for healthcare applications are included in this review.https://www.mdpi.com/1422-0067/24/4/3188nanoparticlesbiopolymerstherapeutic substancesincorporationbiocompatibilityhealthcare |
| spellingShingle | Nika Kučuk Mateja Primožič Željko Knez Maja Leitgeb Sustainable Biodegradable Biopolymer-Based Nanoparticles for Healthcare Applications International Journal of Molecular Sciences nanoparticles biopolymers therapeutic substances incorporation biocompatibility healthcare |
| title | Sustainable Biodegradable Biopolymer-Based Nanoparticles for Healthcare Applications |
| title_full | Sustainable Biodegradable Biopolymer-Based Nanoparticles for Healthcare Applications |
| title_fullStr | Sustainable Biodegradable Biopolymer-Based Nanoparticles for Healthcare Applications |
| title_full_unstemmed | Sustainable Biodegradable Biopolymer-Based Nanoparticles for Healthcare Applications |
| title_short | Sustainable Biodegradable Biopolymer-Based Nanoparticles for Healthcare Applications |
| title_sort | sustainable biodegradable biopolymer based nanoparticles for healthcare applications |
| topic | nanoparticles biopolymers therapeutic substances incorporation biocompatibility healthcare |
| url | https://www.mdpi.com/1422-0067/24/4/3188 |
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