Phytotherapeutic applications of alkaloids in treating breast cancer
Breast cancer is one of the major causes of mortality in women worldwide. The current treatments available are radiation therapy (RT), surgery, endocrine (hormone) therapy (ET), chemotherapy (CT), and targeted therapy. These treatments are associated with certain side effects that demand the use of...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332222011490 |
| _version_ | 1811237692258648064 |
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| author | Shailima Rampogu Thananjeyan Balasubramaniyam Joon-Hwa Lee |
| author_facet | Shailima Rampogu Thananjeyan Balasubramaniyam Joon-Hwa Lee |
| author_sort | Shailima Rampogu |
| collection | DOAJ |
| description | Breast cancer is one of the major causes of mortality in women worldwide. The current treatments available are radiation therapy (RT), surgery, endocrine (hormone) therapy (ET), chemotherapy (CT), and targeted therapy. These treatments are associated with certain side effects that demand the use of natural compounds due to their lower to negligible side effects. One such category of natural compounds is alkaloids. Alkaloids are a group of natural compounds that have gained widespread attention due to their use as potential therapeutics. Alkaloids exert anti-inflammatory and antiviral properties along with antimicrobial activities. In the current review, 12 alkaloids are reviewed in detail for their potential in treating breast cancer. These alkaloids have been shown to induce apoptosis, decrease tumor volume, inhibit cell proliferation and migration, and induce autophagy and they can also be used as a component of combination therapy. This review provides comprehensive information on the in vitro and in vivo therapeutic abilities of alkaloids to counteract breast cancer. |
| first_indexed | 2024-04-12T12:28:49Z |
| format | Article |
| id | doaj.art-7e61e5a0e84749b0bc8989ef95c2cadd |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-12T12:28:49Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-7e61e5a0e84749b0bc8989ef95c2cadd2022-12-22T03:33:06ZengElsevierBiomedicine & Pharmacotherapy0753-33222022-11-01155113760Phytotherapeutic applications of alkaloids in treating breast cancerShailima Rampogu0Thananjeyan Balasubramaniyam1Joon-Hwa Lee2Cachet Big Data Lab, Hyderabad, Telangana, India; Corresponding authors.Department of Chemistry, The Research Institute of Natural Science, Gyeongsang National University, Jinju, Gyeongnam 52828, South KoreaDepartment of Chemistry, The Research Institute of Natural Science, Gyeongsang National University, Jinju, Gyeongnam 52828, South Korea; Corresponding authors.Breast cancer is one of the major causes of mortality in women worldwide. The current treatments available are radiation therapy (RT), surgery, endocrine (hormone) therapy (ET), chemotherapy (CT), and targeted therapy. These treatments are associated with certain side effects that demand the use of natural compounds due to their lower to negligible side effects. One such category of natural compounds is alkaloids. Alkaloids are a group of natural compounds that have gained widespread attention due to their use as potential therapeutics. Alkaloids exert anti-inflammatory and antiviral properties along with antimicrobial activities. In the current review, 12 alkaloids are reviewed in detail for their potential in treating breast cancer. These alkaloids have been shown to induce apoptosis, decrease tumor volume, inhibit cell proliferation and migration, and induce autophagy and they can also be used as a component of combination therapy. This review provides comprehensive information on the in vitro and in vivo therapeutic abilities of alkaloids to counteract breast cancer.http://www.sciencedirect.com/science/article/pii/S0753332222011490Breast cancerAlkaloidsPhytotherapyNatural compounds |
| spellingShingle | Shailima Rampogu Thananjeyan Balasubramaniyam Joon-Hwa Lee Phytotherapeutic applications of alkaloids in treating breast cancer Biomedicine & Pharmacotherapy Breast cancer Alkaloids Phytotherapy Natural compounds |
| title | Phytotherapeutic applications of alkaloids in treating breast cancer |
| title_full | Phytotherapeutic applications of alkaloids in treating breast cancer |
| title_fullStr | Phytotherapeutic applications of alkaloids in treating breast cancer |
| title_full_unstemmed | Phytotherapeutic applications of alkaloids in treating breast cancer |
| title_short | Phytotherapeutic applications of alkaloids in treating breast cancer |
| title_sort | phytotherapeutic applications of alkaloids in treating breast cancer |
| topic | Breast cancer Alkaloids Phytotherapy Natural compounds |
| url | http://www.sciencedirect.com/science/article/pii/S0753332222011490 |
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