Vestibular and Attractor Network Basis of the Head Direction Cell Signal in Subcortical Circuits
Accurate navigation depends on a network of neural systems that encode the moment-to-moment changes in an animal’s directional orientation and location in space. Within this navigation system are head direction (HD) cells, which fire persistently when an animal’s head is pointed in a particular dir...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2012-03-01
|
| Series: | Frontiers in Neural Circuits |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncir.2012.00007/full |
| _version_ | 1819084197405392896 |
|---|---|
| author | Benjamin J Clark Jeffrey S Taube |
| author_facet | Benjamin J Clark Jeffrey S Taube |
| author_sort | Benjamin J Clark |
| collection | DOAJ |
| description | Accurate navigation depends on a network of neural systems that encode the moment-to-moment changes in an animal’s directional orientation and location in space. Within this navigation system are head direction (HD) cells, which fire persistently when an animal’s head is pointed in a particular direction (Sharp et al., 2001a; Taube, 2007). HD cells are widely thought to underlie an animal’s sense of spatial orientation, and research over the last 25+ years has revealed that this robust spatial signal is widely distributed across subcortical and cortical limbic areas. Much of this work has been directed at understanding the functional organization of the HD cell circuitry, and precisely how this signal is generated from sensory and motor systems. The purpose of the present review is to summarize some of the recent studies arguing that the HD cell circuit is largely processed in a hierarchical fashion, following a pathway involving the dorsal tegmental nuclei → lateral mammillary nuclei → anterior thalamus → parahippocampal and retrosplenial cortical regions. We also review recent work identifying bursting cellular activity in the HD cell circuit after lesions of the vestibular system, and relate these observations to the long held view that attractor network mechanisms underlie HD signal generation. Finally, we summarize the work to date suggesting that this network architecture may reside within the tegmento-mammillary circuit. |
| first_indexed | 2024-12-21T20:44:38Z |
| format | Article |
| id | doaj.art-7e61f3aef11747ae9ca1730f29ed60a2 |
| institution | Directory Open Access Journal |
| issn | 1662-5110 |
| language | English |
| last_indexed | 2024-12-21T20:44:38Z |
| publishDate | 2012-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neural Circuits |
| spelling | doaj.art-7e61f3aef11747ae9ca1730f29ed60a22022-12-21T18:50:51ZengFrontiers Media S.A.Frontiers in Neural Circuits1662-51102012-03-01610.3389/fncir.2012.0000720731Vestibular and Attractor Network Basis of the Head Direction Cell Signal in Subcortical CircuitsBenjamin J Clark0Jeffrey S Taube1Dartmouth CollegeDartmouth CollegeAccurate navigation depends on a network of neural systems that encode the moment-to-moment changes in an animal’s directional orientation and location in space. Within this navigation system are head direction (HD) cells, which fire persistently when an animal’s head is pointed in a particular direction (Sharp et al., 2001a; Taube, 2007). HD cells are widely thought to underlie an animal’s sense of spatial orientation, and research over the last 25+ years has revealed that this robust spatial signal is widely distributed across subcortical and cortical limbic areas. Much of this work has been directed at understanding the functional organization of the HD cell circuitry, and precisely how this signal is generated from sensory and motor systems. The purpose of the present review is to summarize some of the recent studies arguing that the HD cell circuit is largely processed in a hierarchical fashion, following a pathway involving the dorsal tegmental nuclei → lateral mammillary nuclei → anterior thalamus → parahippocampal and retrosplenial cortical regions. We also review recent work identifying bursting cellular activity in the HD cell circuit after lesions of the vestibular system, and relate these observations to the long held view that attractor network mechanisms underlie HD signal generation. Finally, we summarize the work to date suggesting that this network architecture may reside within the tegmento-mammillary circuit.http://journal.frontiersin.org/Journal/10.3389/fncir.2012.00007/fullHippocampusentorhinalnavigationSpatial Orientationhead direction |
| spellingShingle | Benjamin J Clark Jeffrey S Taube Vestibular and Attractor Network Basis of the Head Direction Cell Signal in Subcortical Circuits Frontiers in Neural Circuits Hippocampus entorhinal navigation Spatial Orientation head direction |
| title | Vestibular and Attractor Network Basis of the Head Direction Cell Signal in Subcortical Circuits |
| title_full | Vestibular and Attractor Network Basis of the Head Direction Cell Signal in Subcortical Circuits |
| title_fullStr | Vestibular and Attractor Network Basis of the Head Direction Cell Signal in Subcortical Circuits |
| title_full_unstemmed | Vestibular and Attractor Network Basis of the Head Direction Cell Signal in Subcortical Circuits |
| title_short | Vestibular and Attractor Network Basis of the Head Direction Cell Signal in Subcortical Circuits |
| title_sort | vestibular and attractor network basis of the head direction cell signal in subcortical circuits |
| topic | Hippocampus entorhinal navigation Spatial Orientation head direction |
| url | http://journal.frontiersin.org/Journal/10.3389/fncir.2012.00007/full |
| work_keys_str_mv | AT benjaminjclark vestibularandattractornetworkbasisoftheheaddirectioncellsignalinsubcorticalcircuits AT jeffreystaube vestibularandattractornetworkbasisoftheheaddirectioncellsignalinsubcorticalcircuits |