B-cell chronic lymphocytic leukaemia in an African lion (Panthera leo)
A 15-year-old female African lion (Panthera leo) maintained at the Zoological Garden of Pistoia, Tuscany (Italy), showed signs of malaise, dyspnoea, tremors, pale mucous membranes and ataxia for two days prior to death. Complete blood count showed anaemia, thrombocytopaenia and severe lymphocytosis....
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Czech Academy of Agricultural Sciences
2018-09-01
|
| Series: | Veterinární Medicína |
| Subjects: | |
| Online Access: | https://vetmed.agriculturejournals.cz/artkey/vet-201809-0004_b-cell-chronic-lymphocytic-leukaemia-in-an-african-lion-panthera-leo.php |
| _version_ | 1797897527661428736 |
|---|---|
| author | R. Meoli C. Eleni P. Cavicchio M.C. Tonnicchia B. Biancani L. Galosi G. Rossi |
| author_facet | R. Meoli C. Eleni P. Cavicchio M.C. Tonnicchia B. Biancani L. Galosi G. Rossi |
| author_sort | R. Meoli |
| collection | DOAJ |
| description | A 15-year-old female African lion (Panthera leo) maintained at the Zoological Garden of Pistoia, Tuscany (Italy), showed signs of malaise, dyspnoea, tremors, pale mucous membranes and ataxia for two days prior to death. Complete blood count showed anaemia, thrombocytopaenia and severe lymphocytosis. At autopsy, the most relevant finding was severe, generalised splenomegaly. Histologically, high numbers of neoplastic lymphocytes diffusely infiltrated the spleen, liver, heart, pancreas, kidney and lungs. The lymphoid cells were positive for CD79a and negative for CD3 on immunohistochemistry. The histologic features of the neoplastic cells and their immunophenotype are consistent with B-cell lymphocytes. Based on surface membrane co-expression of immunoglobulin M and immunoglobulin D in most neoplastic cells, which indicated that they were naïve, antigen-inexperienced and mature circulating resting B-cells, and consistent with their appearance as small lymphocytes with high nuclear-to-cytoplasmic ratios, a diagnosis of B-cell chronic lymphocytic leukaemia was made. |
| first_indexed | 2024-04-10T07:58:41Z |
| format | Article |
| id | doaj.art-7e64c70e90b946a291f0cfaf04143b97 |
| institution | Directory Open Access Journal |
| issn | 0375-8427 1805-9392 |
| language | English |
| last_indexed | 2024-04-10T07:58:41Z |
| publishDate | 2018-09-01 |
| publisher | Czech Academy of Agricultural Sciences |
| record_format | Article |
| series | Veterinární Medicína |
| spelling | doaj.art-7e64c70e90b946a291f0cfaf04143b972023-02-23T03:50:47ZengCzech Academy of Agricultural SciencesVeterinární Medicína0375-84271805-93922018-09-0163943343710.17221/144/2017-VETMEDvet-201809-0004B-cell chronic lymphocytic leukaemia in an African lion (Panthera leo)R. Meoli0C. Eleni1P. Cavicchio2M.C. Tonnicchia3B. Biancani4L. Galosi5G. Rossi6Experimental Zooprophylactic Institute of Lazio and Tuscany "M. Aleandri", Rome, ItalyExperimental Zooprophylactic Institute of Lazio and Tuscany "M. Aleandri", Rome, ItalyZoological Society of Pistoia, Pistoia, ItalyZoological Society of Pistoia, Pistoia, ItalyPark Oltremare, Riccione, ItalySchool of Biosciences and Veterinary Medicine, University of Camerino, Matelica, ItalySchool of Biosciences and Veterinary Medicine, University of Camerino, Matelica, ItalyA 15-year-old female African lion (Panthera leo) maintained at the Zoological Garden of Pistoia, Tuscany (Italy), showed signs of malaise, dyspnoea, tremors, pale mucous membranes and ataxia for two days prior to death. Complete blood count showed anaemia, thrombocytopaenia and severe lymphocytosis. At autopsy, the most relevant finding was severe, generalised splenomegaly. Histologically, high numbers of neoplastic lymphocytes diffusely infiltrated the spleen, liver, heart, pancreas, kidney and lungs. The lymphoid cells were positive for CD79a and negative for CD3 on immunohistochemistry. The histologic features of the neoplastic cells and their immunophenotype are consistent with B-cell lymphocytes. Based on surface membrane co-expression of immunoglobulin M and immunoglobulin D in most neoplastic cells, which indicated that they were naïve, antigen-inexperienced and mature circulating resting B-cells, and consistent with their appearance as small lymphocytes with high nuclear-to-cytoplasmic ratios, a diagnosis of B-cell chronic lymphocytic leukaemia was made.https://vetmed.agriculturejournals.cz/artkey/vet-201809-0004_b-cell-chronic-lymphocytic-leukaemia-in-an-african-lion-panthera-leo.phplymphocytosis; felineneoplastic disease |
| spellingShingle | R. Meoli C. Eleni P. Cavicchio M.C. Tonnicchia B. Biancani L. Galosi G. Rossi B-cell chronic lymphocytic leukaemia in an African lion (Panthera leo) Veterinární Medicína lymphocytosis; feline neoplastic disease |
| title | B-cell chronic lymphocytic leukaemia in an African lion (Panthera leo) |
| title_full | B-cell chronic lymphocytic leukaemia in an African lion (Panthera leo) |
| title_fullStr | B-cell chronic lymphocytic leukaemia in an African lion (Panthera leo) |
| title_full_unstemmed | B-cell chronic lymphocytic leukaemia in an African lion (Panthera leo) |
| title_short | B-cell chronic lymphocytic leukaemia in an African lion (Panthera leo) |
| title_sort | b cell chronic lymphocytic leukaemia in an african lion panthera leo |
| topic | lymphocytosis; feline neoplastic disease |
| url | https://vetmed.agriculturejournals.cz/artkey/vet-201809-0004_b-cell-chronic-lymphocytic-leukaemia-in-an-african-lion-panthera-leo.php |
| work_keys_str_mv | AT rmeoli bcellchroniclymphocyticleukaemiainanafricanlionpantheraleo AT celeni bcellchroniclymphocyticleukaemiainanafricanlionpantheraleo AT pcavicchio bcellchroniclymphocyticleukaemiainanafricanlionpantheraleo AT mctonnicchia bcellchroniclymphocyticleukaemiainanafricanlionpantheraleo AT bbiancani bcellchroniclymphocyticleukaemiainanafricanlionpantheraleo AT lgalosi bcellchroniclymphocyticleukaemiainanafricanlionpantheraleo AT grossi bcellchroniclymphocyticleukaemiainanafricanlionpantheraleo |