Chronic effects of aerobic exercise on gene expression of LOX-1 receptor in the heart of rats fed with high fat diet
Objective(s):Lectin-like low density lipoprotein receptor (LOX-1) has pivot role in vascular complications, which is upregulated in numerous pathological conditions. Since exercise has beneficial effects in prevention of hyperlipidemic complications, present study examined protective effects of aero...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2015-08-01
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| Series: | Iranian Journal of Basic Medical Sciences |
| Subjects: | |
| Online Access: | http://ijbms.mums.ac.ir/pdf_4732_18e65787957c4a41b93c471b7e7b5797.html |
| _version_ | 1819042627008331776 |
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| author | Simin Riahi Mohammad Taghi Mohammadi Vahid Sobhani Mansureh Soleimany |
| author_facet | Simin Riahi Mohammad Taghi Mohammadi Vahid Sobhani Mansureh Soleimany |
| author_sort | Simin Riahi |
| collection | DOAJ |
| description | Objective(s):Lectin-like low density lipoprotein receptor (LOX-1) has pivot role in vascular complications, which is upregulated in numerous pathological conditions. Since exercise has beneficial effects in prevention of hyperlipidemic complications, present study examined protective effects of aerobic exercise through reduction of LOX-1 expression in heart during dyslipidemia.
Materials and Methods: Four groups of rats were used (N=25): Normal, Normal and exercise, High fat and High fat and exercise. High fat diet (HFD) was made by adding 10% animal oil, 2% cholesterol and 0.5% colic acid to standard rodent chow. Exercise protocol consisted of swimming 1 hr/day, and 5 days/week for 8 weeks. Plasma lipids were evaluated at the end of experiment, 48 hr after final session of exercise. At the end, rats were sacrificed and heart was removed for determination of malondialdehyde (MDA) content, and LOX-1 expression.
Results:HFD meaningfully changed lipid profile (>50%), but chronic exercise had no significant effects on lipid profile. LOX-1 expression was significantly increased in heart of rats fed with HFD, while swimming exercise considerably reduced gene expression of LOX-1. MDA content was significantly enhanced in rats fed with HFD (4.37±0.6 nmol/mg, P |
| first_indexed | 2024-12-21T09:43:53Z |
| format | Article |
| id | doaj.art-7e66d1b129724e89b41ec62920388637 |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-12-21T09:43:53Z |
| publishDate | 2015-08-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-7e66d1b129724e89b41ec629203886372022-12-21T19:08:24ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742015-08-011888058124732Chronic effects of aerobic exercise on gene expression of LOX-1 receptor in the heart of rats fed with high fat dietSimin Riahi0Mohammad Taghi Mohammadi1Vahid Sobhani2Mansureh Soleimany3Exercise Physiology Research Center, Baqiyatallah University of Medical Sciences, Tehran, IranDepartment of Physiology and Biophysics, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, IranExercise Physiology Research Center, Baqiyatallah University of Medical Sciences, Tehran, IranDepartment of Anatomy, Faculty of Medicine, Iran University of Medical Sciences, Tehran, IranObjective(s):Lectin-like low density lipoprotein receptor (LOX-1) has pivot role in vascular complications, which is upregulated in numerous pathological conditions. Since exercise has beneficial effects in prevention of hyperlipidemic complications, present study examined protective effects of aerobic exercise through reduction of LOX-1 expression in heart during dyslipidemia. Materials and Methods: Four groups of rats were used (N=25): Normal, Normal and exercise, High fat and High fat and exercise. High fat diet (HFD) was made by adding 10% animal oil, 2% cholesterol and 0.5% colic acid to standard rodent chow. Exercise protocol consisted of swimming 1 hr/day, and 5 days/week for 8 weeks. Plasma lipids were evaluated at the end of experiment, 48 hr after final session of exercise. At the end, rats were sacrificed and heart was removed for determination of malondialdehyde (MDA) content, and LOX-1 expression. Results:HFD meaningfully changed lipid profile (>50%), but chronic exercise had no significant effects on lipid profile. LOX-1 expression was significantly increased in heart of rats fed with HFD, while swimming exercise considerably reduced gene expression of LOX-1. MDA content was significantly enhanced in rats fed with HFD (4.37±0.6 nmol/mg, Phttp://ijbms.mums.ac.ir/pdf_4732_18e65787957c4a41b93c471b7e7b5797.htmlDyslipidemiaLOX-1 receptorOxidative stressSwimming exercise |
| spellingShingle | Simin Riahi Mohammad Taghi Mohammadi Vahid Sobhani Mansureh Soleimany Chronic effects of aerobic exercise on gene expression of LOX-1 receptor in the heart of rats fed with high fat diet Iranian Journal of Basic Medical Sciences Dyslipidemia LOX-1 receptor Oxidative stress Swimming exercise |
| title | Chronic effects of aerobic exercise on gene expression of LOX-1 receptor in the heart of rats fed with high fat diet |
| title_full | Chronic effects of aerobic exercise on gene expression of LOX-1 receptor in the heart of rats fed with high fat diet |
| title_fullStr | Chronic effects of aerobic exercise on gene expression of LOX-1 receptor in the heart of rats fed with high fat diet |
| title_full_unstemmed | Chronic effects of aerobic exercise on gene expression of LOX-1 receptor in the heart of rats fed with high fat diet |
| title_short | Chronic effects of aerobic exercise on gene expression of LOX-1 receptor in the heart of rats fed with high fat diet |
| title_sort | chronic effects of aerobic exercise on gene expression of lox 1 receptor in the heart of rats fed with high fat diet |
| topic | Dyslipidemia LOX-1 receptor Oxidative stress Swimming exercise |
| url | http://ijbms.mums.ac.ir/pdf_4732_18e65787957c4a41b93c471b7e7b5797.html |
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