Lipid metabolism as a target for cancer drug resistance: progress and prospects
Cancer is the world’s leading cause of human death today, and the treatment process of cancer is highly complex. Chemotherapy and targeted therapy are commonly used in cancer treatment, and the emergence of drug resistance is a significant problem in cancer treatment. Therefore, the mechanism of dru...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1274335/full |
| _version_ | 1797671607796236288 |
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| author | Zi’an Wang Zi’an Wang Yueqin Wang Yueqin Wang Zeyun Li Zeyun Li Wenhua Xue Wenhua Xue Shousen Hu Xiangzhen Kong Xiangzhen Kong |
| author_facet | Zi’an Wang Zi’an Wang Yueqin Wang Yueqin Wang Zeyun Li Zeyun Li Wenhua Xue Wenhua Xue Shousen Hu Xiangzhen Kong Xiangzhen Kong |
| author_sort | Zi’an Wang |
| collection | DOAJ |
| description | Cancer is the world’s leading cause of human death today, and the treatment process of cancer is highly complex. Chemotherapy and targeted therapy are commonly used in cancer treatment, and the emergence of drug resistance is a significant problem in cancer treatment. Therefore, the mechanism of drug resistance during cancer treatment has become a hot issue in current research. A series of studies have found that lipid metabolism is closely related to cancer drug resistance. This paper details the changes of lipid metabolism in drug resistance and how lipid metabolism affects drug resistance. More importantly, most studies have reported that combination therapy may lead to changes in lipid-related metabolic pathways, which may reverse the development of cancer drug resistance and enhance or rescue the sensitivity to therapeutic drugs. This paper summarizes the progress of drug design targeting lipid metabolism in improving drug resistance, and providing new ideas and strategies for future tumor treatment. Therefore, this paper reviews the issues of combining medications with lipid metabolism and drug resistance. |
| first_indexed | 2024-03-11T21:18:00Z |
| format | Article |
| id | doaj.art-7e67cb8702834968969e3ea7b4966e73 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-11T21:18:00Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-7e67cb8702834968969e3ea7b4966e732023-09-28T13:12:48ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-09-011410.3389/fphar.2023.12743351274335Lipid metabolism as a target for cancer drug resistance: progress and prospectsZi’an Wang0Zi’an Wang1Yueqin Wang2Yueqin Wang3Zeyun Li4Zeyun Li5Wenhua Xue6Wenhua Xue7Shousen Hu8Xiangzhen Kong9Xiangzhen Kong10Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Key Laboratory of Precision Clinical Pharmacy, Zhengzhou University, Zhengzhou, ChinaDepartment of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Key Laboratory of Precision Clinical Pharmacy, Zhengzhou University, Zhengzhou, ChinaDepartment of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Key Laboratory of Precision Clinical Pharmacy, Zhengzhou University, Zhengzhou, ChinaDepartment of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Key Laboratory of Precision Clinical Pharmacy, Zhengzhou University, Zhengzhou, ChinaDepartment of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Key Laboratory of Precision Clinical Pharmacy, Zhengzhou University, Zhengzhou, ChinaCancer is the world’s leading cause of human death today, and the treatment process of cancer is highly complex. Chemotherapy and targeted therapy are commonly used in cancer treatment, and the emergence of drug resistance is a significant problem in cancer treatment. Therefore, the mechanism of drug resistance during cancer treatment has become a hot issue in current research. A series of studies have found that lipid metabolism is closely related to cancer drug resistance. This paper details the changes of lipid metabolism in drug resistance and how lipid metabolism affects drug resistance. More importantly, most studies have reported that combination therapy may lead to changes in lipid-related metabolic pathways, which may reverse the development of cancer drug resistance and enhance or rescue the sensitivity to therapeutic drugs. This paper summarizes the progress of drug design targeting lipid metabolism in improving drug resistance, and providing new ideas and strategies for future tumor treatment. Therefore, this paper reviews the issues of combining medications with lipid metabolism and drug resistance.https://www.frontiersin.org/articles/10.3389/fphar.2023.1274335/fulldrug resistancelipid metabolismcombination druginhibitorchemotherapy resistancetargeted therapy |
| spellingShingle | Zi’an Wang Zi’an Wang Yueqin Wang Yueqin Wang Zeyun Li Zeyun Li Wenhua Xue Wenhua Xue Shousen Hu Xiangzhen Kong Xiangzhen Kong Lipid metabolism as a target for cancer drug resistance: progress and prospects Frontiers in Pharmacology drug resistance lipid metabolism combination drug inhibitor chemotherapy resistance targeted therapy |
| title | Lipid metabolism as a target for cancer drug resistance: progress and prospects |
| title_full | Lipid metabolism as a target for cancer drug resistance: progress and prospects |
| title_fullStr | Lipid metabolism as a target for cancer drug resistance: progress and prospects |
| title_full_unstemmed | Lipid metabolism as a target for cancer drug resistance: progress and prospects |
| title_short | Lipid metabolism as a target for cancer drug resistance: progress and prospects |
| title_sort | lipid metabolism as a target for cancer drug resistance progress and prospects |
| topic | drug resistance lipid metabolism combination drug inhibitor chemotherapy resistance targeted therapy |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1274335/full |
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