Association between interleukin-1 receptor polymorphism and human herpesvirus 8 among lymphoma patients
Background: Human herpesvirus 8 (HHV-8) stimulates lymphoproliferation, by activating the signaling pathway of the interleukin-6 receptor, along with several other regulatory mechanisms. The presence of specific genetic variations governing immune responses can impact the promotion or suppression of...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-01-01
|
| Series: | Medical Journal of Babylon |
| Subjects: | |
| Online Access: | http://www.medjbabylon.org/article.asp?issn=1812-156X;year=2023;volume=20;issue=4;spage=875;epage=881;aulast=Abbas |
| _version_ | 1797221287876100096 |
|---|---|
| author | Ameer J Abbas Al-Jawdhari Shakir H Mohammed Al-Alwany |
| author_facet | Ameer J Abbas Al-Jawdhari Shakir H Mohammed Al-Alwany |
| author_sort | Ameer J Abbas Al-Jawdhari |
| collection | DOAJ |
| description | Background: Human herpesvirus 8 (HHV-8) stimulates lymphoproliferation, by activating the signaling pathway of the interleukin-6 receptor, along with several other regulatory mechanisms. The presence of specific genetic variations governing immune responses can impact the promotion or suppression of malignant lymphoma. Polymorphisms in the gene cluster of interleukin-1 (IL-1) have been identified as significant contributors to the regulation of inflammation. Objective: This study aimed to determine the percentage HHV-8 and whether polymorphisms at IL-1 receptor antagonist (IL-1ra) locus modulate the risk of developing malignant lymphoma of a group of Iraqi patients in the Mid-Euphrates Sector, Iraq. Materials and Methods: A case-control study was conducted on 200 specimens obtained from patients with lymphoma and individuals without any apparent health conditions who served as the control group (considered normal individuals). The specimens were collected from various general hospitals and private clinics located in the Middle Euphrates region of Iraq. The study population included individuals aged between 17 and 75 years. Specimen collection took place between October 2022 and February 2023. Conventional polymerase chain reaction (PCR) was chosen for the detection of HHV-8 as well as IL-1ra gene polymorphism by sequencing. Results: According to PCR detection, 31 out of 64 (48.4%) of the specimens revealed PCR detection positivity for HHV-8, whereas 33 out of 64 (51.6%) specimens showed negative detection for HHV-8. The lymphoma which were most HHV-8-infected are related to the age stratum (56–75 years), accounted for 48%, whereas the age strata 15–35 years, and 36–55 years, each accounted for 23% and 29%, respectively. Conclusion: In view of the relatively small numbers included in our study, the present results indicate the possibility that HHV-8 and IL-1ra polymorphism may play a role in the tumor biology of lymphocyte and may contribute to their development. |
| first_indexed | 2024-04-24T13:03:03Z |
| format | Article |
| id | doaj.art-7e6886d3c7fe4884afdfc6f830a838a1 |
| institution | Directory Open Access Journal |
| issn | 1812-156X 2312-6760 |
| language | English |
| last_indexed | 2024-04-24T13:03:03Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Medical Journal of Babylon |
| spelling | doaj.art-7e6886d3c7fe4884afdfc6f830a838a12024-04-05T10:12:38ZengWolters Kluwer Medknow PublicationsMedical Journal of Babylon1812-156X2312-67602023-01-0120487588110.4103/MJBL.MJBL_649_23Association between interleukin-1 receptor polymorphism and human herpesvirus 8 among lymphoma patientsAmeer J Abbas Al-JawdhariShakir H Mohammed Al-AlwanyBackground: Human herpesvirus 8 (HHV-8) stimulates lymphoproliferation, by activating the signaling pathway of the interleukin-6 receptor, along with several other regulatory mechanisms. The presence of specific genetic variations governing immune responses can impact the promotion or suppression of malignant lymphoma. Polymorphisms in the gene cluster of interleukin-1 (IL-1) have been identified as significant contributors to the regulation of inflammation. Objective: This study aimed to determine the percentage HHV-8 and whether polymorphisms at IL-1 receptor antagonist (IL-1ra) locus modulate the risk of developing malignant lymphoma of a group of Iraqi patients in the Mid-Euphrates Sector, Iraq. Materials and Methods: A case-control study was conducted on 200 specimens obtained from patients with lymphoma and individuals without any apparent health conditions who served as the control group (considered normal individuals). The specimens were collected from various general hospitals and private clinics located in the Middle Euphrates region of Iraq. The study population included individuals aged between 17 and 75 years. Specimen collection took place between October 2022 and February 2023. Conventional polymerase chain reaction (PCR) was chosen for the detection of HHV-8 as well as IL-1ra gene polymorphism by sequencing. Results: According to PCR detection, 31 out of 64 (48.4%) of the specimens revealed PCR detection positivity for HHV-8, whereas 33 out of 64 (51.6%) specimens showed negative detection for HHV-8. The lymphoma which were most HHV-8-infected are related to the age stratum (56–75 years), accounted for 48%, whereas the age strata 15–35 years, and 36–55 years, each accounted for 23% and 29%, respectively. Conclusion: In view of the relatively small numbers included in our study, the present results indicate the possibility that HHV-8 and IL-1ra polymorphism may play a role in the tumor biology of lymphocyte and may contribute to their development.http://www.medjbabylon.org/article.asp?issn=1812-156X;year=2023;volume=20;issue=4;spage=875;epage=881;aulast=Abbashhv-8il-1ralymphomapcrpolymorphismsequencing |
| spellingShingle | Ameer J Abbas Al-Jawdhari Shakir H Mohammed Al-Alwany Association between interleukin-1 receptor polymorphism and human herpesvirus 8 among lymphoma patients Medical Journal of Babylon hhv-8 il-1ra lymphoma pcr polymorphism sequencing |
| title | Association between interleukin-1 receptor polymorphism and human herpesvirus 8 among lymphoma patients |
| title_full | Association between interleukin-1 receptor polymorphism and human herpesvirus 8 among lymphoma patients |
| title_fullStr | Association between interleukin-1 receptor polymorphism and human herpesvirus 8 among lymphoma patients |
| title_full_unstemmed | Association between interleukin-1 receptor polymorphism and human herpesvirus 8 among lymphoma patients |
| title_short | Association between interleukin-1 receptor polymorphism and human herpesvirus 8 among lymphoma patients |
| title_sort | association between interleukin 1 receptor polymorphism and human herpesvirus 8 among lymphoma patients |
| topic | hhv-8 il-1ra lymphoma pcr polymorphism sequencing |
| url | http://www.medjbabylon.org/article.asp?issn=1812-156X;year=2023;volume=20;issue=4;spage=875;epage=881;aulast=Abbas |
| work_keys_str_mv | AT ameerjabbasaljawdhari associationbetweeninterleukin1receptorpolymorphismandhumanherpesvirus8amonglymphomapatients AT shakirhmohammedalalwany associationbetweeninterleukin1receptorpolymorphismandhumanherpesvirus8amonglymphomapatients |