The Effects of Propofol or Dexmedetomidine Sedation on Postoperative Recovery in Elderly Patients Receiving Lower Limb Surgery under Spinal Anesthesia: A Retrospective Propensity Score-Matched Analysis
Propofol and dexmedetomidine are the two most popular intravenous sedatives during anesthesia. However, data comparing the effects of these two sedatives during spinal anesthesia on postoperative recovery are still insufficient. We retrospectively analyzed the medical records of patients aged ≥65 ye...
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MDPI AG
2021-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/1/135 |
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| author | Jin-Woo Park Eun-Kyoung Kim Hun-Taek Lee Seongjoo Park Sang-Hwan Do |
| author_facet | Jin-Woo Park Eun-Kyoung Kim Hun-Taek Lee Seongjoo Park Sang-Hwan Do |
| author_sort | Jin-Woo Park |
| collection | DOAJ |
| description | Propofol and dexmedetomidine are the two most popular intravenous sedatives during anesthesia. However, data comparing the effects of these two sedatives during spinal anesthesia on postoperative recovery are still insufficient. We retrospectively analyzed the medical records of patients aged ≥65 years who underwent orthopedic surgery under spinal anesthesia between March 2012 and February 2017. The patients were allocated into two groups according to the intraoperative sedatives: the propofol group and dexmedetomidine group. We analyzed the incidence of postoperative delirium, analgesic requirement, and rescue anti-emetic treatment. A total of 1045 patients were included in the analysis. After propensity score matching with the propofol group, the dexmedetomidine group showed a lower incidence of postoperative delirium (odds ratio, 0.19; 95% CI, 0.07–0.56; <i>p</i> = 0.011). Postoperative analgesic and anti-emetic requirement were not significantly different between the two groups (<i>p</i> = 0.156 and 0.245, respectively). Multivariate logistic regression analysis revealed that intraoperative sedation, age, preoperative albumin level, and hip surgery were significantly associated with the incidence of postoperative delirium. This study showed that intraoperative dexmedetomidine sedation under spinal anesthesia during lower limb surgery is associated with a lower incidence of postoperative delirium compared with propofol sedation. |
| first_indexed | 2024-03-10T13:31:59Z |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T13:31:59Z |
| publishDate | 2021-01-01 |
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| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-7e6888258fb9496f90f55b8b8f27e5dd2023-11-21T07:53:43ZengMDPI AGJournal of Clinical Medicine2077-03832021-01-0110113510.3390/jcm10010135The Effects of Propofol or Dexmedetomidine Sedation on Postoperative Recovery in Elderly Patients Receiving Lower Limb Surgery under Spinal Anesthesia: A Retrospective Propensity Score-Matched AnalysisJin-Woo Park0Eun-Kyoung Kim1Hun-Taek Lee2Seongjoo Park3Sang-Hwan Do4Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam 13620, KoreaDepartment of Anesthesiology and Pain Medicine, Noh Jong Hoon Plastic Surgery, Seoul 06030, KoreaDepartment of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam 13620, KoreaDepartment of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam 13620, KoreaDepartment of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam 13620, KoreaPropofol and dexmedetomidine are the two most popular intravenous sedatives during anesthesia. However, data comparing the effects of these two sedatives during spinal anesthesia on postoperative recovery are still insufficient. We retrospectively analyzed the medical records of patients aged ≥65 years who underwent orthopedic surgery under spinal anesthesia between March 2012 and February 2017. The patients were allocated into two groups according to the intraoperative sedatives: the propofol group and dexmedetomidine group. We analyzed the incidence of postoperative delirium, analgesic requirement, and rescue anti-emetic treatment. A total of 1045 patients were included in the analysis. After propensity score matching with the propofol group, the dexmedetomidine group showed a lower incidence of postoperative delirium (odds ratio, 0.19; 95% CI, 0.07–0.56; <i>p</i> = 0.011). Postoperative analgesic and anti-emetic requirement were not significantly different between the two groups (<i>p</i> = 0.156 and 0.245, respectively). Multivariate logistic regression analysis revealed that intraoperative sedation, age, preoperative albumin level, and hip surgery were significantly associated with the incidence of postoperative delirium. This study showed that intraoperative dexmedetomidine sedation under spinal anesthesia during lower limb surgery is associated with a lower incidence of postoperative delirium compared with propofol sedation.https://www.mdpi.com/2077-0383/10/1/135dexmedetomidineintraoperative sedationpostoperative deliriumpropofol |
| spellingShingle | Jin-Woo Park Eun-Kyoung Kim Hun-Taek Lee Seongjoo Park Sang-Hwan Do The Effects of Propofol or Dexmedetomidine Sedation on Postoperative Recovery in Elderly Patients Receiving Lower Limb Surgery under Spinal Anesthesia: A Retrospective Propensity Score-Matched Analysis Journal of Clinical Medicine dexmedetomidine intraoperative sedation postoperative delirium propofol |
| title | The Effects of Propofol or Dexmedetomidine Sedation on Postoperative Recovery in Elderly Patients Receiving Lower Limb Surgery under Spinal Anesthesia: A Retrospective Propensity Score-Matched Analysis |
| title_full | The Effects of Propofol or Dexmedetomidine Sedation on Postoperative Recovery in Elderly Patients Receiving Lower Limb Surgery under Spinal Anesthesia: A Retrospective Propensity Score-Matched Analysis |
| title_fullStr | The Effects of Propofol or Dexmedetomidine Sedation on Postoperative Recovery in Elderly Patients Receiving Lower Limb Surgery under Spinal Anesthesia: A Retrospective Propensity Score-Matched Analysis |
| title_full_unstemmed | The Effects of Propofol or Dexmedetomidine Sedation on Postoperative Recovery in Elderly Patients Receiving Lower Limb Surgery under Spinal Anesthesia: A Retrospective Propensity Score-Matched Analysis |
| title_short | The Effects of Propofol or Dexmedetomidine Sedation on Postoperative Recovery in Elderly Patients Receiving Lower Limb Surgery under Spinal Anesthesia: A Retrospective Propensity Score-Matched Analysis |
| title_sort | effects of propofol or dexmedetomidine sedation on postoperative recovery in elderly patients receiving lower limb surgery under spinal anesthesia a retrospective propensity score matched analysis |
| topic | dexmedetomidine intraoperative sedation postoperative delirium propofol |
| url | https://www.mdpi.com/2077-0383/10/1/135 |
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