Clinical efficacy of triamcinolone acetonide and Ranibizumab in the treatment of diabetic diffuse macular edema
AIM:To compare the clinical curative effect of triamcinolone acetonide and Ranibizumab on diffuse diabetic macular edema(DME). <p>METHODS: We collected 84 cases of patients with diffuse DME treated in our hospital from February 2016 to May 2017. According to 1:1 matching method, they were divi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2018-06-01
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| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2018/6/201806025.pdf |
| Summary: | AIM:To compare the clinical curative effect of triamcinolone acetonide and Ranibizumab on diffuse diabetic macular edema(DME). <p>METHODS: We collected 84 cases of patients with diffuse DME treated in our hospital from February 2016 to May 2017. According to 1:1 matching method, they were divided into Ⅰ, Ⅱ groups. They were all treated with laser photocoagulation. Preoperative auxiliary application of triamcinolone acetonide was given to Group Ⅰ, while Group Ⅱ received preoperative application of ranibizumab. After treatment, the efficacy of the two groups were analyzed and compared. <p>RESULTS: The total clinical efficiency of Group Ⅱ at 3mo after treatment was 93%, higher than that of Group Ⅰ(77%; <i>χ</i><sup>2</sup>=4.981, <i>P</i>=0.025). Compared with before treatment, BCVA and CMT of the two groups at each time after treatment were significantly improved(<i>P</i><0.05). BCVA of Group Ⅱ at 1 and 3mo after treatment was better than that of Group Ⅰ(<i>P</i><0.05); CMT of Group Ⅱ at 1, 3 and 6mo after treatment improved more than that of Group Ⅰ, with significant difference(<i>P</i><0.05); occurrence rate of adverse reactions Group Ⅰ and Group Ⅱ were 17% and 13% with no significant statistical difference(<i>χ</i><sup>2</sup>=0.243, <i>P</i>=0.621). There were no serious adverse reactions such as retinal detachment, endophthalmitis or cataract in the two groups. <p>CONCLUSION: Compared with triamcinolone acetonide, the effect of ranibizumab on diffuse diabetic macular edema is better, and has high clinical value. |
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| ISSN: | 1672-5123 1672-5123 |