Clinical efficacy of triamcinolone acetonide and Ranibizumab in the treatment of diabetic diffuse macular edema
AIM:To compare the clinical curative effect of triamcinolone acetonide and Ranibizumab on diffuse diabetic macular edema(DME). <p>METHODS: We collected 84 cases of patients with diffuse DME treated in our hospital from February 2016 to May 2017. According to 1:1 matching method, they were divi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2018-06-01
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| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2018/6/201806025.pdf |
| _version_ | 1818133652619395072 |
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| author | Bi-Hua Xie Yu He Mei Xin Zhuo Chen |
| author_facet | Bi-Hua Xie Yu He Mei Xin Zhuo Chen |
| author_sort | Bi-Hua Xie |
| collection | DOAJ |
| description | AIM:To compare the clinical curative effect of triamcinolone acetonide and Ranibizumab on diffuse diabetic macular edema(DME). <p>METHODS: We collected 84 cases of patients with diffuse DME treated in our hospital from February 2016 to May 2017. According to 1:1 matching method, they were divided into Ⅰ, Ⅱ groups. They were all treated with laser photocoagulation. Preoperative auxiliary application of triamcinolone acetonide was given to Group Ⅰ, while Group Ⅱ received preoperative application of ranibizumab. After treatment, the efficacy of the two groups were analyzed and compared. <p>RESULTS: The total clinical efficiency of Group Ⅱ at 3mo after treatment was 93%, higher than that of Group Ⅰ(77%; <i>χ</i><sup>2</sup>=4.981, <i>P</i>=0.025). Compared with before treatment, BCVA and CMT of the two groups at each time after treatment were significantly improved(<i>P</i><0.05). BCVA of Group Ⅱ at 1 and 3mo after treatment was better than that of Group Ⅰ(<i>P</i><0.05); CMT of Group Ⅱ at 1, 3 and 6mo after treatment improved more than that of Group Ⅰ, with significant difference(<i>P</i><0.05); occurrence rate of adverse reactions Group Ⅰ and Group Ⅱ were 17% and 13% with no significant statistical difference(<i>χ</i><sup>2</sup>=0.243, <i>P</i>=0.621). There were no serious adverse reactions such as retinal detachment, endophthalmitis or cataract in the two groups. <p>CONCLUSION: Compared with triamcinolone acetonide, the effect of ranibizumab on diffuse diabetic macular edema is better, and has high clinical value. |
| first_indexed | 2024-12-11T08:56:08Z |
| format | Article |
| id | doaj.art-7e69461e93a447aaa0f826581f5a5216 |
| institution | Directory Open Access Journal |
| issn | 1672-5123 1672-5123 |
| language | English |
| last_indexed | 2024-12-11T08:56:08Z |
| publishDate | 2018-06-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-7e69461e93a447aaa0f826581f5a52162022-12-22T01:13:52ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51231672-51232018-06-011861089109210.3980/j.issn.1672-5123.2018.6.25Clinical efficacy of triamcinolone acetonide and Ranibizumab in the treatment of diabetic diffuse macular edemaBi-Hua Xie0Yu He1Mei Xin2Zhuo Chen3Department of Ophthalmology, Chengdu First People's Hospital, Chengdu 610041, Sichuan Province, ChinaDepartment of Ophthalmology, Chengdu First People's Hospital, Chengdu 610041, Sichuan Province, ChinaDepartment of Ophthalmology, Chengdu First People's Hospital, Chengdu 610041, Sichuan Province, ChinaDepartment of Ophthalmology, Chengdu First People's Hospital, Chengdu 610041, Sichuan Province, ChinaAIM:To compare the clinical curative effect of triamcinolone acetonide and Ranibizumab on diffuse diabetic macular edema(DME). <p>METHODS: We collected 84 cases of patients with diffuse DME treated in our hospital from February 2016 to May 2017. According to 1:1 matching method, they were divided into Ⅰ, Ⅱ groups. They were all treated with laser photocoagulation. Preoperative auxiliary application of triamcinolone acetonide was given to Group Ⅰ, while Group Ⅱ received preoperative application of ranibizumab. After treatment, the efficacy of the two groups were analyzed and compared. <p>RESULTS: The total clinical efficiency of Group Ⅱ at 3mo after treatment was 93%, higher than that of Group Ⅰ(77%; <i>χ</i><sup>2</sup>=4.981, <i>P</i>=0.025). Compared with before treatment, BCVA and CMT of the two groups at each time after treatment were significantly improved(<i>P</i><0.05). BCVA of Group Ⅱ at 1 and 3mo after treatment was better than that of Group Ⅰ(<i>P</i><0.05); CMT of Group Ⅱ at 1, 3 and 6mo after treatment improved more than that of Group Ⅰ, with significant difference(<i>P</i><0.05); occurrence rate of adverse reactions Group Ⅰ and Group Ⅱ were 17% and 13% with no significant statistical difference(<i>χ</i><sup>2</sup>=0.243, <i>P</i>=0.621). There were no serious adverse reactions such as retinal detachment, endophthalmitis or cataract in the two groups. <p>CONCLUSION: Compared with triamcinolone acetonide, the effect of ranibizumab on diffuse diabetic macular edema is better, and has high clinical value.http://ies.ijo.cn/cn_publish/2018/6/201806025.pdfdiffuse diabetic macular edematriamcinolone acetonideranibizumablaser photocoagulationlaser photocoagulation |
| spellingShingle | Bi-Hua Xie Yu He Mei Xin Zhuo Chen Clinical efficacy of triamcinolone acetonide and Ranibizumab in the treatment of diabetic diffuse macular edema Guoji Yanke Zazhi diffuse diabetic macular edema triamcinolone acetonide ranibizumab laser photocoagulation laser photocoagulation |
| title | Clinical efficacy of triamcinolone acetonide and Ranibizumab in the treatment of diabetic diffuse macular edema |
| title_full | Clinical efficacy of triamcinolone acetonide and Ranibizumab in the treatment of diabetic diffuse macular edema |
| title_fullStr | Clinical efficacy of triamcinolone acetonide and Ranibizumab in the treatment of diabetic diffuse macular edema |
| title_full_unstemmed | Clinical efficacy of triamcinolone acetonide and Ranibizumab in the treatment of diabetic diffuse macular edema |
| title_short | Clinical efficacy of triamcinolone acetonide and Ranibizumab in the treatment of diabetic diffuse macular edema |
| title_sort | clinical efficacy of triamcinolone acetonide and ranibizumab in the treatment of diabetic diffuse macular edema |
| topic | diffuse diabetic macular edema triamcinolone acetonide ranibizumab laser photocoagulation laser photocoagulation |
| url | http://ies.ijo.cn/cn_publish/2018/6/201806025.pdf |
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