Multi‐Functional Liposome: A Powerful Theranostic Nano‐Platform Enhancing Photodynamic Therapy
Abstract Although photodynamic therapy (PDT) has promising advantages in almost non‐invasion, low drug resistance, and low dark toxicity, it still suffers from limitations in the lipophilic nature of most photosensitizers (PSs), short half‐life of PS in plasma, poor tissue penetration, and low tumor...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-08-01
|
| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202100876 |
| _version_ | 1818639728559259648 |
|---|---|
| author | Xiamin Cheng Jing Gao Yang Ding Yao Lu Qiancheng Wei Dezhi Cui Jiali Fan Xiaoman Li Ershu Zhu Yongna Lu Qiong Wu Lin Li Wei Huang |
| author_facet | Xiamin Cheng Jing Gao Yang Ding Yao Lu Qiancheng Wei Dezhi Cui Jiali Fan Xiaoman Li Ershu Zhu Yongna Lu Qiong Wu Lin Li Wei Huang |
| author_sort | Xiamin Cheng |
| collection | DOAJ |
| description | Abstract Although photodynamic therapy (PDT) has promising advantages in almost non‐invasion, low drug resistance, and low dark toxicity, it still suffers from limitations in the lipophilic nature of most photosensitizers (PSs), short half‐life of PS in plasma, poor tissue penetration, and low tumor specificity. To overcome these limitations and enhance PDT, liposomes, as excellent multi‐functional nano‐carriers for drug delivery, have been extensively studied in multi‐functional theranostics, including liposomal PS, targeted drug delivery, controllable drug release, image‐guided therapy, and combined therapy. This review provides researchers with a useful reference in liposome‐based drug delivery. |
| first_indexed | 2024-12-16T22:59:59Z |
| format | Article |
| id | doaj.art-7e69ea377878421586f05d116c5385e7 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-12-16T22:59:59Z |
| publishDate | 2021-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-7e69ea377878421586f05d116c5385e72022-12-21T22:12:46ZengWileyAdvanced Science2198-38442021-08-01816n/an/a10.1002/advs.202100876Multi‐Functional Liposome: A Powerful Theranostic Nano‐Platform Enhancing Photodynamic TherapyXiamin Cheng0Jing Gao1Yang Ding2Yao Lu3Qiancheng Wei4Dezhi Cui5Jiali Fan6Xiaoman Li7Ershu Zhu8Yongna Lu9Qiong Wu10Lin Li11Wei Huang12Institute of Advanced Synthesis School of Chemistry and Molecular Engineering Nanjing Tech University (NanjingTech) Nanjing 211816 P. R. ChinaInstitute of Advanced Synthesis School of Chemistry and Molecular Engineering Nanjing Tech University (NanjingTech) Nanjing 211816 P. R. ChinaKey Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM) Nanjing Tech University (NanjingTech) Nanjing 211816 P. R. ChinaKey Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM) Nanjing Tech University (NanjingTech) Nanjing 211816 P. R. ChinaInstitute of Advanced Synthesis School of Chemistry and Molecular Engineering Nanjing Tech University (NanjingTech) Nanjing 211816 P. R. ChinaInstitute of Advanced Synthesis School of Chemistry and Molecular Engineering Nanjing Tech University (NanjingTech) Nanjing 211816 P. R. ChinaInstitute of Advanced Synthesis School of Chemistry and Molecular Engineering Nanjing Tech University (NanjingTech) Nanjing 211816 P. R. ChinaInstitute of Advanced Synthesis School of Chemistry and Molecular Engineering Nanjing Tech University (NanjingTech) Nanjing 211816 P. R. ChinaInstitute of Advanced Synthesis School of Chemistry and Molecular Engineering Nanjing Tech University (NanjingTech) Nanjing 211816 P. R. ChinaInstitute of Advanced Synthesis School of Chemistry and Molecular Engineering Nanjing Tech University (NanjingTech) Nanjing 211816 P. R. ChinaKey Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM) Nanjing Tech University (NanjingTech) Nanjing 211816 P. R. ChinaKey Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM) Nanjing Tech University (NanjingTech) Nanjing 211816 P. R. ChinaKey Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM) Nanjing Tech University (NanjingTech) Nanjing 211816 P. R. ChinaAbstract Although photodynamic therapy (PDT) has promising advantages in almost non‐invasion, low drug resistance, and low dark toxicity, it still suffers from limitations in the lipophilic nature of most photosensitizers (PSs), short half‐life of PS in plasma, poor tissue penetration, and low tumor specificity. To overcome these limitations and enhance PDT, liposomes, as excellent multi‐functional nano‐carriers for drug delivery, have been extensively studied in multi‐functional theranostics, including liposomal PS, targeted drug delivery, controllable drug release, image‐guided therapy, and combined therapy. This review provides researchers with a useful reference in liposome‐based drug delivery.https://doi.org/10.1002/advs.202100876combined therapydrug deliveryliposomesphotodynamic therapytheranostics |
| spellingShingle | Xiamin Cheng Jing Gao Yang Ding Yao Lu Qiancheng Wei Dezhi Cui Jiali Fan Xiaoman Li Ershu Zhu Yongna Lu Qiong Wu Lin Li Wei Huang Multi‐Functional Liposome: A Powerful Theranostic Nano‐Platform Enhancing Photodynamic Therapy Advanced Science combined therapy drug delivery liposomes photodynamic therapy theranostics |
| title | Multi‐Functional Liposome: A Powerful Theranostic Nano‐Platform Enhancing Photodynamic Therapy |
| title_full | Multi‐Functional Liposome: A Powerful Theranostic Nano‐Platform Enhancing Photodynamic Therapy |
| title_fullStr | Multi‐Functional Liposome: A Powerful Theranostic Nano‐Platform Enhancing Photodynamic Therapy |
| title_full_unstemmed | Multi‐Functional Liposome: A Powerful Theranostic Nano‐Platform Enhancing Photodynamic Therapy |
| title_short | Multi‐Functional Liposome: A Powerful Theranostic Nano‐Platform Enhancing Photodynamic Therapy |
| title_sort | multi functional liposome a powerful theranostic nano platform enhancing photodynamic therapy |
| topic | combined therapy drug delivery liposomes photodynamic therapy theranostics |
| url | https://doi.org/10.1002/advs.202100876 |
| work_keys_str_mv | AT xiamincheng multifunctionalliposomeapowerfultheranosticnanoplatformenhancingphotodynamictherapy AT jinggao multifunctionalliposomeapowerfultheranosticnanoplatformenhancingphotodynamictherapy AT yangding multifunctionalliposomeapowerfultheranosticnanoplatformenhancingphotodynamictherapy AT yaolu multifunctionalliposomeapowerfultheranosticnanoplatformenhancingphotodynamictherapy AT qianchengwei multifunctionalliposomeapowerfultheranosticnanoplatformenhancingphotodynamictherapy AT dezhicui multifunctionalliposomeapowerfultheranosticnanoplatformenhancingphotodynamictherapy AT jialifan multifunctionalliposomeapowerfultheranosticnanoplatformenhancingphotodynamictherapy AT xiaomanli multifunctionalliposomeapowerfultheranosticnanoplatformenhancingphotodynamictherapy AT ershuzhu multifunctionalliposomeapowerfultheranosticnanoplatformenhancingphotodynamictherapy AT yongnalu multifunctionalliposomeapowerfultheranosticnanoplatformenhancingphotodynamictherapy AT qiongwu multifunctionalliposomeapowerfultheranosticnanoplatformenhancingphotodynamictherapy AT linli multifunctionalliposomeapowerfultheranosticnanoplatformenhancingphotodynamictherapy AT weihuang multifunctionalliposomeapowerfultheranosticnanoplatformenhancingphotodynamictherapy |