Relationship between FGF 23, SDMA, Urea, Creatinine and Phosphate in Relation to Feline Chronic Kidney Disease
Chronic kidney disease (CKD) is a common diagnosis in older cats, and its prevalence increases with age. Conventional indirect biomarkers of glomerular filtration rate (GFR) have their limitations, and are not efficient in detecting early decreases in glomerular filtration rate. Recently, symmetric...
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| Format: | Article |
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MDPI AG
2022-08-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/12/17/2247 |
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| author | Simona Grelová Martina Karasová Csilla Tóthová Terézia Kisková Darina Baranová Branislav Lukáč Mária Fialkovičová Alena Micháľová Lukáš Kunay Miroslav Svoboda |
| author_facet | Simona Grelová Martina Karasová Csilla Tóthová Terézia Kisková Darina Baranová Branislav Lukáč Mária Fialkovičová Alena Micháľová Lukáš Kunay Miroslav Svoboda |
| author_sort | Simona Grelová |
| collection | DOAJ |
| description | Chronic kidney disease (CKD) is a common diagnosis in older cats, and its prevalence increases with age. Conventional indirect biomarkers of glomerular filtration rate (GFR) have their limitations, and are not efficient in detecting early decreases in glomerular filtration rate. Recently, symmetric dimethylarginine (SDMA) concentrations have been proposed as a novel biomarker of GFR for the early detection of CKD. This study discusses the relationship between SDMA, FGF 23 and previously used indicators of kidney function, mainly creatinine, urea and phosphate. Ninety-nine cats were included in this study. Based on their SDMA values, 48 cats had CKD and the remaining 51 cats were used as a healthy control group. Serum of these cats was assayed for creatinine, urea and phosphate concentrations as well as FGF 23 values, and correlations between them were evaluated. Cats with CKD had higher FGF 23 concentrations than healthy cats, and no correlation was found between FGF 23 and SDMA, nor between FGF 23 and phosphate. On the other hand, phosphate strongly correlated with SDMA, urea and creatinine, making it a possible independent factor of CKD progression. |
| first_indexed | 2024-03-10T03:07:37Z |
| format | Article |
| id | doaj.art-7e6b5611b61844069a0840e9f42b12ea |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-10T03:07:37Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-7e6b5611b61844069a0840e9f42b12ea2023-11-23T12:37:43ZengMDPI AGAnimals2076-26152022-08-011217224710.3390/ani12172247Relationship between FGF 23, SDMA, Urea, Creatinine and Phosphate in Relation to Feline Chronic Kidney DiseaseSimona Grelová0Martina Karasová1Csilla Tóthová2Terézia Kisková3Darina Baranová4Branislav Lukáč5Mária Fialkovičová6Alena Micháľová7Lukáš Kunay8Miroslav Svoboda9Small Animal Clinic, University of Veterinary Medicine and Pharmacy, 04001 Košice, SlovakiaSmall Animal Clinic, University of Veterinary Medicine and Pharmacy, 04001 Košice, SlovakiaClinic of Ruminants, University of Veterinary Medicine and Pharmacy, 04001 Košice, SlovakiaFaculty of Science, University of Pavol Jozef Šafárik, 04154 Košice, SlovakiaSmall Animal Clinic, University of Veterinary Medicine and Pharmacy, 04001 Košice, SlovakiaSmall Animal Clinic, University of Veterinary Medicine and Pharmacy, 04001 Košice, SlovakiaSmall Animal Clinic, University of Veterinary Medicine and Pharmacy, 04001 Košice, SlovakiaSmall Animal Clinic, University of Veterinary Medicine and Pharmacy, 04001 Košice, SlovakiaSmall Animal Clinic, University of Veterinary Medicine and Pharmacy, 04001 Košice, SlovakiaSmall Animal Clinic, University of Veterinary Medicine and Pharmacy, 04001 Košice, SlovakiaChronic kidney disease (CKD) is a common diagnosis in older cats, and its prevalence increases with age. Conventional indirect biomarkers of glomerular filtration rate (GFR) have their limitations, and are not efficient in detecting early decreases in glomerular filtration rate. Recently, symmetric dimethylarginine (SDMA) concentrations have been proposed as a novel biomarker of GFR for the early detection of CKD. This study discusses the relationship between SDMA, FGF 23 and previously used indicators of kidney function, mainly creatinine, urea and phosphate. Ninety-nine cats were included in this study. Based on their SDMA values, 48 cats had CKD and the remaining 51 cats were used as a healthy control group. Serum of these cats was assayed for creatinine, urea and phosphate concentrations as well as FGF 23 values, and correlations between them were evaluated. Cats with CKD had higher FGF 23 concentrations than healthy cats, and no correlation was found between FGF 23 and SDMA, nor between FGF 23 and phosphate. On the other hand, phosphate strongly correlated with SDMA, urea and creatinine, making it a possible independent factor of CKD progression.https://www.mdpi.com/2076-2615/12/17/2247chronic kidney diseasecatfibroblast growth factor 23symmetric dimethylarginine |
| spellingShingle | Simona Grelová Martina Karasová Csilla Tóthová Terézia Kisková Darina Baranová Branislav Lukáč Mária Fialkovičová Alena Micháľová Lukáš Kunay Miroslav Svoboda Relationship between FGF 23, SDMA, Urea, Creatinine and Phosphate in Relation to Feline Chronic Kidney Disease Animals chronic kidney disease cat fibroblast growth factor 23 symmetric dimethylarginine |
| title | Relationship between FGF 23, SDMA, Urea, Creatinine and Phosphate in Relation to Feline Chronic Kidney Disease |
| title_full | Relationship between FGF 23, SDMA, Urea, Creatinine and Phosphate in Relation to Feline Chronic Kidney Disease |
| title_fullStr | Relationship between FGF 23, SDMA, Urea, Creatinine and Phosphate in Relation to Feline Chronic Kidney Disease |
| title_full_unstemmed | Relationship between FGF 23, SDMA, Urea, Creatinine and Phosphate in Relation to Feline Chronic Kidney Disease |
| title_short | Relationship between FGF 23, SDMA, Urea, Creatinine and Phosphate in Relation to Feline Chronic Kidney Disease |
| title_sort | relationship between fgf 23 sdma urea creatinine and phosphate in relation to feline chronic kidney disease |
| topic | chronic kidney disease cat fibroblast growth factor 23 symmetric dimethylarginine |
| url | https://www.mdpi.com/2076-2615/12/17/2247 |
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