Tailoring Macromolecular Structure of Cationic Polymers towards Efficient Contact Active Antimicrobial Surfaces
The aim of this work is the preparation of contact active antimicrobial films by blending copolymers with quaternary ammonium salts and polyacrylonitrile as matrix material. A series of copolymers based on acrylonitrile and methacrylic monomers with quaternizable groups were designed with the purpos...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-02-01
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| Series: | Polymers |
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| Online Access: | http://www.mdpi.com/2073-4360/10/3/241 |
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| author | Rubén Tejero Beatriz Gutiérrez Daniel López Fátima López-Fabal José L. Gómez-Garcés Alexandra Muñoz-Bonilla Marta Fernández-García |
| author_facet | Rubén Tejero Beatriz Gutiérrez Daniel López Fátima López-Fabal José L. Gómez-Garcés Alexandra Muñoz-Bonilla Marta Fernández-García |
| author_sort | Rubén Tejero |
| collection | DOAJ |
| description | The aim of this work is the preparation of contact active antimicrobial films by blending copolymers with quaternary ammonium salts and polyacrylonitrile as matrix material. A series of copolymers based on acrylonitrile and methacrylic monomers with quaternizable groups were designed with the purpose of investigating the influence of their chemical and structural characteristics on the antimicrobial activity of these surfaces. The biocide activity of these systems was studied against different microorganisms, such as the Gram-positive bacteria Staphylococcus aureus and the Gram-negative bacteria Pseudomona aeruginosa and the yeast Candida parapsilosis. The results confirmed that parameters such as flexibility and polarity of the antimicrobial polymers immobilized on the surfaces strongly affect the efficiency against microorganisms. In contrast to the behavior of copolymers in water solution, when they are tethered to the surface, the active cationic groups are less accessible and then, the mobility of the side chain is critical for a good contact with the microorganism. Blend films composed of copolymers with high positive charge density and chain mobility present up to a more than 99.999% killing efficiency against the studied microorganisms. |
| first_indexed | 2024-04-12T17:24:33Z |
| format | Article |
| id | doaj.art-7e6b73d1338245c58586e6770180b45e |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-04-12T17:24:33Z |
| publishDate | 2018-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-7e6b73d1338245c58586e6770180b45e2022-12-22T03:23:21ZengMDPI AGPolymers2073-43602018-02-0110324110.3390/polym10030241polym10030241Tailoring Macromolecular Structure of Cationic Polymers towards Efficient Contact Active Antimicrobial SurfacesRubén Tejero0Beatriz Gutiérrez1Daniel López2Fátima López-Fabal3José L. Gómez-Garcés4Alexandra Muñoz-Bonilla5Marta Fernández-García6Instituto de Ciencia y Tecnología de Polímeros (ICTP-CSIC), C/Juan de la Cierva 3, 28006 Madrid, SpainInstituto de Ciencia y Tecnología de Polímeros (ICTP-CSIC), C/Juan de la Cierva 3, 28006 Madrid, SpainInstituto de Ciencia y Tecnología de Polímeros (ICTP-CSIC), C/Juan de la Cierva 3, 28006 Madrid, SpainHospital Universitario de Móstoles, C/Río Júcar, s/n, Móstoles, 28935 Madrid, SpainHospital Universitario de Móstoles, C/Río Júcar, s/n, Móstoles, 28935 Madrid, SpainInstituto de Ciencia y Tecnología de Polímeros (ICTP-CSIC), C/Juan de la Cierva 3, 28006 Madrid, SpainInstituto de Ciencia y Tecnología de Polímeros (ICTP-CSIC), C/Juan de la Cierva 3, 28006 Madrid, SpainThe aim of this work is the preparation of contact active antimicrobial films by blending copolymers with quaternary ammonium salts and polyacrylonitrile as matrix material. A series of copolymers based on acrylonitrile and methacrylic monomers with quaternizable groups were designed with the purpose of investigating the influence of their chemical and structural characteristics on the antimicrobial activity of these surfaces. The biocide activity of these systems was studied against different microorganisms, such as the Gram-positive bacteria Staphylococcus aureus and the Gram-negative bacteria Pseudomona aeruginosa and the yeast Candida parapsilosis. The results confirmed that parameters such as flexibility and polarity of the antimicrobial polymers immobilized on the surfaces strongly affect the efficiency against microorganisms. In contrast to the behavior of copolymers in water solution, when they are tethered to the surface, the active cationic groups are less accessible and then, the mobility of the side chain is critical for a good contact with the microorganism. Blend films composed of copolymers with high positive charge density and chain mobility present up to a more than 99.999% killing efficiency against the studied microorganisms.http://www.mdpi.com/2073-4360/10/3/241cationic polymersblendssurfacesantimicrobial |
| spellingShingle | Rubén Tejero Beatriz Gutiérrez Daniel López Fátima López-Fabal José L. Gómez-Garcés Alexandra Muñoz-Bonilla Marta Fernández-García Tailoring Macromolecular Structure of Cationic Polymers towards Efficient Contact Active Antimicrobial Surfaces Polymers cationic polymers blends surfaces antimicrobial |
| title | Tailoring Macromolecular Structure of Cationic Polymers towards Efficient Contact Active Antimicrobial Surfaces |
| title_full | Tailoring Macromolecular Structure of Cationic Polymers towards Efficient Contact Active Antimicrobial Surfaces |
| title_fullStr | Tailoring Macromolecular Structure of Cationic Polymers towards Efficient Contact Active Antimicrobial Surfaces |
| title_full_unstemmed | Tailoring Macromolecular Structure of Cationic Polymers towards Efficient Contact Active Antimicrobial Surfaces |
| title_short | Tailoring Macromolecular Structure of Cationic Polymers towards Efficient Contact Active Antimicrobial Surfaces |
| title_sort | tailoring macromolecular structure of cationic polymers towards efficient contact active antimicrobial surfaces |
| topic | cationic polymers blends surfaces antimicrobial |
| url | http://www.mdpi.com/2073-4360/10/3/241 |
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