Chemokines in Prediabetes and Type 2 Diabetes: A Meta-Analysis
BackgroundA growing number of studies found inconsistent results on the role of chemokines in the progression of type 2 diabetes (T2DM) and prediabetes (PDM). The purpose of this meta-analysis was to summarize the results of previous studies on the association between the chemokines system and T2DM/...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-05-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.622438/full |
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| author | Xiongfeng Pan Xiongfeng Pan Atipatsa C. Kaminga Atipatsa C. Kaminga Shi Wu Wen Shi Wu Wen Aizhong Liu |
| author_facet | Xiongfeng Pan Xiongfeng Pan Atipatsa C. Kaminga Atipatsa C. Kaminga Shi Wu Wen Shi Wu Wen Aizhong Liu |
| author_sort | Xiongfeng Pan |
| collection | DOAJ |
| description | BackgroundA growing number of studies found inconsistent results on the role of chemokines in the progression of type 2 diabetes (T2DM) and prediabetes (PDM). The purpose of this meta-analysis was to summarize the results of previous studies on the association between the chemokines system and T2DM/PDM.MethodsWe searched in the databases, PubMed, Web of Science, Embase and Cochrane Library, for eligible studies published not later than March 1, 2020. Data extraction was performed independently by 2 reviewers, on a standardized, prepiloted form. Group differences in chemokines concentrations were summarized using the standardized mean difference (SMD) with a 95% confidence interval (CI), calculated by performing a meta-analysis using the random-effects model.ResultsWe identified 98 relevant studies that investigated the association between 32 different chemokines and T2DM/PDM. Altogether, these studies involved 14,708 patients and 14,574 controls. Results showed that the concentrations of CCL1, CCL2, CCL4, CCL5, CCL11, CXCL8, CXCL10 and CX3CL1 in the T2DM patients were significantly higher than that in the controls, while no difference in these concentrations was found between the PDM patients and controls.ConclusionProgression of T2DM may be associated with elevated concentrations of chemokines.Meta-Analysis RegistrationPROSPERO, identifier CRD42019148305. |
| first_indexed | 2024-12-14T21:47:59Z |
| format | Article |
| id | doaj.art-7e71fd045ff54e47b3aee06dcc371463 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-14T21:47:59Z |
| publishDate | 2021-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-7e71fd045ff54e47b3aee06dcc3714632022-12-21T22:46:19ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-05-011210.3389/fimmu.2021.622438622438Chemokines in Prediabetes and Type 2 Diabetes: A Meta-AnalysisXiongfeng Pan0Xiongfeng Pan1Atipatsa C. Kaminga2Atipatsa C. Kaminga3Shi Wu Wen4Shi Wu Wen5Aizhong Liu6Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, ChinaHunan Provincial Key Laboratory of Clinical Epidemiology, Xiangya School of Public Health, Central South University, Changsha, ChinaDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, ChinaDepartment of Mathematics and Statistics, Mzuzu University, Mzuzu, MalawiOMNI Research Group, Ottawa Hospital Research Institute, Ottawa, ON, CanadaDepartment of Obstetrics and Gynaecology and School of Epidemiology and Public Health, University of Ottawa Faculty of Medicine, Ottawa, ON, CanadaDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, ChinaBackgroundA growing number of studies found inconsistent results on the role of chemokines in the progression of type 2 diabetes (T2DM) and prediabetes (PDM). The purpose of this meta-analysis was to summarize the results of previous studies on the association between the chemokines system and T2DM/PDM.MethodsWe searched in the databases, PubMed, Web of Science, Embase and Cochrane Library, for eligible studies published not later than March 1, 2020. Data extraction was performed independently by 2 reviewers, on a standardized, prepiloted form. Group differences in chemokines concentrations were summarized using the standardized mean difference (SMD) with a 95% confidence interval (CI), calculated by performing a meta-analysis using the random-effects model.ResultsWe identified 98 relevant studies that investigated the association between 32 different chemokines and T2DM/PDM. Altogether, these studies involved 14,708 patients and 14,574 controls. Results showed that the concentrations of CCL1, CCL2, CCL4, CCL5, CCL11, CXCL8, CXCL10 and CX3CL1 in the T2DM patients were significantly higher than that in the controls, while no difference in these concentrations was found between the PDM patients and controls.ConclusionProgression of T2DM may be associated with elevated concentrations of chemokines.Meta-Analysis RegistrationPROSPERO, identifier CRD42019148305.https://www.frontiersin.org/articles/10.3389/fimmu.2021.622438/fullchemokinestype 2 diabetesprediabetesinflammationmeta-analysis |
| spellingShingle | Xiongfeng Pan Xiongfeng Pan Atipatsa C. Kaminga Atipatsa C. Kaminga Shi Wu Wen Shi Wu Wen Aizhong Liu Chemokines in Prediabetes and Type 2 Diabetes: A Meta-Analysis Frontiers in Immunology chemokines type 2 diabetes prediabetes inflammation meta-analysis |
| title | Chemokines in Prediabetes and Type 2 Diabetes: A Meta-Analysis |
| title_full | Chemokines in Prediabetes and Type 2 Diabetes: A Meta-Analysis |
| title_fullStr | Chemokines in Prediabetes and Type 2 Diabetes: A Meta-Analysis |
| title_full_unstemmed | Chemokines in Prediabetes and Type 2 Diabetes: A Meta-Analysis |
| title_short | Chemokines in Prediabetes and Type 2 Diabetes: A Meta-Analysis |
| title_sort | chemokines in prediabetes and type 2 diabetes a meta analysis |
| topic | chemokines type 2 diabetes prediabetes inflammation meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.622438/full |
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