RdRp mutations are associated with SARS-CoV-2 genome evolution
COVID-19, caused by the novel SARS-CoV-2 virus, started in China in late 2019, and soon became a global pandemic. With the help of thousands of viral genome sequences that have been accumulating, it has become possible to track the evolution of the viral genome over time as it spread across the worl...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
PeerJ Inc.
2020-07-01
|
| Series: | PeerJ |
| Subjects: | |
| Online Access: | https://peerj.com/articles/9587.pdf |
| _version_ | 1827610684673753088 |
|---|---|
| author | Doğa Eskier Gökhan Karakülah Aslı Suner Yavuz Oktay |
| author_facet | Doğa Eskier Gökhan Karakülah Aslı Suner Yavuz Oktay |
| author_sort | Doğa Eskier |
| collection | DOAJ |
| description | COVID-19, caused by the novel SARS-CoV-2 virus, started in China in late 2019, and soon became a global pandemic. With the help of thousands of viral genome sequences that have been accumulating, it has become possible to track the evolution of the viral genome over time as it spread across the world. An important question that still needs to be answered is whether any of the common mutations affect the viral properties, and therefore the disease characteristics. Therefore, we sought to understand the effects of mutations in RNA-dependent RNA polymerase (RdRp), particularly the common 14408C>T mutation, on mutation rate and viral spread. By focusing on mutations in the slowly evolving M or E genes, we aimed to minimize the effects of selective pressure. Our results indicate that 14408C>T mutation increases the mutation rate, while the third-most common RdRp mutation, 15324C>T, has the opposite effect. It is possible that 14408C>T mutation may have contributed to the dominance of its co-mutations in Europe and elsewhere. |
| first_indexed | 2024-03-09T07:53:40Z |
| format | Article |
| id | doaj.art-7e72440b22134bce95f9016d8846dd24 |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T07:53:40Z |
| publishDate | 2020-07-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
| series | PeerJ |
| spelling | doaj.art-7e72440b22134bce95f9016d8846dd242023-12-03T01:19:42ZengPeerJ Inc.PeerJ2167-83592020-07-018e958710.7717/peerj.9587RdRp mutations are associated with SARS-CoV-2 genome evolutionDoğa Eskier0Gökhan Karakülah1Aslı Suner2Yavuz Oktay3Izmir Biomedicine and Genome Center (IBG), Izmir, TurkeyIzmir Biomedicine and Genome Center (IBG), Izmir, TurkeyDepartment of Biostatistics and Medical Informatics, Faculty of Medicine, Ege University, Izmir, TurkeyIzmir Biomedicine and Genome Center (IBG), Izmir, TurkeyCOVID-19, caused by the novel SARS-CoV-2 virus, started in China in late 2019, and soon became a global pandemic. With the help of thousands of viral genome sequences that have been accumulating, it has become possible to track the evolution of the viral genome over time as it spread across the world. An important question that still needs to be answered is whether any of the common mutations affect the viral properties, and therefore the disease characteristics. Therefore, we sought to understand the effects of mutations in RNA-dependent RNA polymerase (RdRp), particularly the common 14408C>T mutation, on mutation rate and viral spread. By focusing on mutations in the slowly evolving M or E genes, we aimed to minimize the effects of selective pressure. Our results indicate that 14408C>T mutation increases the mutation rate, while the third-most common RdRp mutation, 15324C>T, has the opposite effect. It is possible that 14408C>T mutation may have contributed to the dominance of its co-mutations in Europe and elsewhere.https://peerj.com/articles/9587.pdfSARS-CoV-2COVID-19RNA-dependent RNA polymeraseRdRpMutation rate |
| spellingShingle | Doğa Eskier Gökhan Karakülah Aslı Suner Yavuz Oktay RdRp mutations are associated with SARS-CoV-2 genome evolution PeerJ SARS-CoV-2 COVID-19 RNA-dependent RNA polymerase RdRp Mutation rate |
| title | RdRp mutations are associated with SARS-CoV-2 genome evolution |
| title_full | RdRp mutations are associated with SARS-CoV-2 genome evolution |
| title_fullStr | RdRp mutations are associated with SARS-CoV-2 genome evolution |
| title_full_unstemmed | RdRp mutations are associated with SARS-CoV-2 genome evolution |
| title_short | RdRp mutations are associated with SARS-CoV-2 genome evolution |
| title_sort | rdrp mutations are associated with sars cov 2 genome evolution |
| topic | SARS-CoV-2 COVID-19 RNA-dependent RNA polymerase RdRp Mutation rate |
| url | https://peerj.com/articles/9587.pdf |
| work_keys_str_mv | AT dogaeskier rdrpmutationsareassociatedwithsarscov2genomeevolution AT gokhankarakulah rdrpmutationsareassociatedwithsarscov2genomeevolution AT aslısuner rdrpmutationsareassociatedwithsarscov2genomeevolution AT yavuzoktay rdrpmutationsareassociatedwithsarscov2genomeevolution |