Optical coherence tomography for the diagnosis, monitoring and guiding of treatment for neovascular age-related macular degeneration: a systematic review and economic evaluation
Background: Age-related macular degeneration is the most common cause of sight impairment in the UK. In neovascular age-related macular degeneration (nAMD), vision worsens rapidly (over weeks) due to abnormal blood vessels developing that leak fluid and blood at the macula. Objectives: To determine...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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NIHR Journals Library
2014-12-01
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| Series: | Health Technology Assessment |
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| Online Access: | https://doi.org/10.3310/hta18690 |
| _version_ | 1817990062675066880 |
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| author | Graham Mowatt Rodolfo Hernández Mayret Castillo Noemi Lois Andrew Elders Cynthia Fraser Olatunde Aremu Winfried Amoaku Jennifer Burr Andrew Lotery Craig Ramsay Augusto Azuara-Blanco |
| author_facet | Graham Mowatt Rodolfo Hernández Mayret Castillo Noemi Lois Andrew Elders Cynthia Fraser Olatunde Aremu Winfried Amoaku Jennifer Burr Andrew Lotery Craig Ramsay Augusto Azuara-Blanco |
| author_sort | Graham Mowatt |
| collection | DOAJ |
| description | Background: Age-related macular degeneration is the most common cause of sight impairment in the UK. In neovascular age-related macular degeneration (nAMD), vision worsens rapidly (over weeks) due to abnormal blood vessels developing that leak fluid and blood at the macula. Objectives: To determine the optimal role of optical coherence tomography (OCT) in diagnosing people newly presenting with suspected nAMD and monitoring those previously diagnosed with the disease. Data sources: Databases searched: MEDLINE (1946 to March 2013), MEDLINE In-Process & Other Non-Indexed Citations (March 2013), EMBASE (1988 to March 2013), Biosciences Information Service (1995 to March 2013), Science Citation Index (1995 to March 2013), The Cochrane Library (Issue 2 2013), Database of Abstracts of Reviews of Effects (inception to March 2013), Medion (inception to March 2013), Health Technology Assessment database (inception to March 2013). Review methods: Types of studies: direct/indirect studies reporting diagnostic outcomes. Index test: time domain optical coherence tomography (TD-OCT) or spectral domain optical coherence tomography (SD-OCT). Comparators: clinical evaluation, visual acuity, Amsler grid, colour fundus photographs, infrared reflectance, red-free images/blue reflectance, fundus autofluorescence imaging, indocyanine green angiography, preferential hyperacuity perimetry, microperimetry. Reference standard: fundus fluorescein angiography (FFA). Risk of bias was assessed using quality assessment of diagnostic accuracy studies, version 2. Meta-analysis models were fitted using hierarchical summary receiver operating characteristic curves. A Markov model was developed (65-year-old cohort, nAMD prevalence 70%), with nine strategies for diagnosis and/or monitoring, and cost–utility analysis conducted. NHS and Personal Social Services perspective was adopted. Costs (2011/12 prices) and quality-adjusted life-years (QALYs) were discounted (3.5%). Deterministic and probabilistic sensitivity analyses were performed. Results: In pooled estimates of diagnostic studies (all TD-OCT), sensitivity and specificity [95% confidence interval (CI)] was 88% (46% to 98%) and 78% (64% to 88%) respectively. For monitoring, the pooled sensitivity and specificity (95% CI) was 85% (72% to 93%) and 48% (30% to 67%) respectively. The FFA for diagnosis and nurse-technician-led monitoring strategy had the lowest cost (£39,769; QALYs 10.473) and dominated all others except FFA for diagnosis and ophthalmologist-led monitoring (£44,649; QALYs 10.575; incremental cost-effectiveness ratio £47,768). The least costly strategy had a 46.4% probability of being cost-effective at £30,000 willingness-to-pay threshold. Limitations: Very few studies provided sufficient information for inclusion in meta-analyses. Only a few studies reported other tests; for some tests no studies were identified. The modelling was hampered by a lack of data on the diagnostic accuracy of strategies involving several tests. Conclusions: Based on a small body of evidence of variable quality, OCT had high sensitivity and moderate specificity for diagnosis, and relatively high sensitivity but low specificity for monitoring. Strategies involving OCT alone for diagnosis and/or monitoring were unlikely to be cost-effective. Further research is required on (i) the performance of SD-OCT compared with FFA, especially for monitoring but also for diagnosis; (ii) the performance of strategies involving combinations/sequences of tests, for diagnosis and monitoring; (iii) the likelihood of active and inactive nAMD becoming inactive or active respectively; and (iv) assessment of treatment-associated utility weights (e.g. decrements), through a preference-based study. Study registration: This study is registered as PROSPERO CRD42012001930. Funding: The National Institute for Health Research Health Technology Assessment programme. |
| first_indexed | 2024-04-14T00:54:39Z |
| format | Article |
| id | doaj.art-7e735152c8524c2293cc75a61ca63f02 |
| institution | Directory Open Access Journal |
| issn | 1366-5278 2046-4924 |
| language | English |
| last_indexed | 2024-04-14T00:54:39Z |
| publishDate | 2014-12-01 |
| publisher | NIHR Journals Library |
| record_format | Article |
| series | Health Technology Assessment |
| spelling | doaj.art-7e735152c8524c2293cc75a61ca63f022022-12-22T02:21:40ZengNIHR Journals LibraryHealth Technology Assessment1366-52782046-49242014-12-01186910.3310/hta1869010/57/22Optical coherence tomography for the diagnosis, monitoring and guiding of treatment for neovascular age-related macular degeneration: a systematic review and economic evaluationGraham Mowatt0Rodolfo Hernández1Mayret Castillo2Noemi Lois3Andrew Elders4Cynthia Fraser5Olatunde Aremu6Winfried Amoaku7Jennifer Burr8Andrew Lotery9Craig Ramsay10Augusto Azuara-Blanco11Health Services Research Unit, University of Aberdeen, Aberdeen, UKHealth Services Research Unit, University of Aberdeen, Aberdeen, UKHealth Services Research Unit, University of Aberdeen, Aberdeen, UKCentre for Experimental Medicine, Queen’s University Belfast, Belfast, UKHealth Services Research Unit, University of Aberdeen, Aberdeen, UKHealth Services Research Unit, University of Aberdeen, Aberdeen, UKHealth Economics Research Unit, University of Aberdeen, Aberdeen, UKDepartment of Ophthalmology, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, UKMedical and Biosocial Sciences, School of Medicine, University of St Andrews, St Andrews, UKClinical Neurosciences Research Group, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UKHealth Services Research Unit, University of Aberdeen, Aberdeen, UKCentre for Experimental Medicine, Queen’s University Belfast, Belfast, UKBackground: Age-related macular degeneration is the most common cause of sight impairment in the UK. In neovascular age-related macular degeneration (nAMD), vision worsens rapidly (over weeks) due to abnormal blood vessels developing that leak fluid and blood at the macula. Objectives: To determine the optimal role of optical coherence tomography (OCT) in diagnosing people newly presenting with suspected nAMD and monitoring those previously diagnosed with the disease. Data sources: Databases searched: MEDLINE (1946 to March 2013), MEDLINE In-Process & Other Non-Indexed Citations (March 2013), EMBASE (1988 to March 2013), Biosciences Information Service (1995 to March 2013), Science Citation Index (1995 to March 2013), The Cochrane Library (Issue 2 2013), Database of Abstracts of Reviews of Effects (inception to March 2013), Medion (inception to March 2013), Health Technology Assessment database (inception to March 2013). Review methods: Types of studies: direct/indirect studies reporting diagnostic outcomes. Index test: time domain optical coherence tomography (TD-OCT) or spectral domain optical coherence tomography (SD-OCT). Comparators: clinical evaluation, visual acuity, Amsler grid, colour fundus photographs, infrared reflectance, red-free images/blue reflectance, fundus autofluorescence imaging, indocyanine green angiography, preferential hyperacuity perimetry, microperimetry. Reference standard: fundus fluorescein angiography (FFA). Risk of bias was assessed using quality assessment of diagnostic accuracy studies, version 2. Meta-analysis models were fitted using hierarchical summary receiver operating characteristic curves. A Markov model was developed (65-year-old cohort, nAMD prevalence 70%), with nine strategies for diagnosis and/or monitoring, and cost–utility analysis conducted. NHS and Personal Social Services perspective was adopted. Costs (2011/12 prices) and quality-adjusted life-years (QALYs) were discounted (3.5%). Deterministic and probabilistic sensitivity analyses were performed. Results: In pooled estimates of diagnostic studies (all TD-OCT), sensitivity and specificity [95% confidence interval (CI)] was 88% (46% to 98%) and 78% (64% to 88%) respectively. For monitoring, the pooled sensitivity and specificity (95% CI) was 85% (72% to 93%) and 48% (30% to 67%) respectively. The FFA for diagnosis and nurse-technician-led monitoring strategy had the lowest cost (£39,769; QALYs 10.473) and dominated all others except FFA for diagnosis and ophthalmologist-led monitoring (£44,649; QALYs 10.575; incremental cost-effectiveness ratio £47,768). The least costly strategy had a 46.4% probability of being cost-effective at £30,000 willingness-to-pay threshold. Limitations: Very few studies provided sufficient information for inclusion in meta-analyses. Only a few studies reported other tests; for some tests no studies were identified. The modelling was hampered by a lack of data on the diagnostic accuracy of strategies involving several tests. Conclusions: Based on a small body of evidence of variable quality, OCT had high sensitivity and moderate specificity for diagnosis, and relatively high sensitivity but low specificity for monitoring. Strategies involving OCT alone for diagnosis and/or monitoring were unlikely to be cost-effective. Further research is required on (i) the performance of SD-OCT compared with FFA, especially for monitoring but also for diagnosis; (ii) the performance of strategies involving combinations/sequences of tests, for diagnosis and monitoring; (iii) the likelihood of active and inactive nAMD becoming inactive or active respectively; and (iv) assessment of treatment-associated utility weights (e.g. decrements), through a preference-based study. Study registration: This study is registered as PROSPERO CRD42012001930. Funding: The National Institute for Health Research Health Technology Assessment programme.https://doi.org/10.3310/hta18690systematic revieweconomic evaluationage-related macular degenerationneovascular age-related macular degenerationoptical coherence tomography |
| spellingShingle | Graham Mowatt Rodolfo Hernández Mayret Castillo Noemi Lois Andrew Elders Cynthia Fraser Olatunde Aremu Winfried Amoaku Jennifer Burr Andrew Lotery Craig Ramsay Augusto Azuara-Blanco Optical coherence tomography for the diagnosis, monitoring and guiding of treatment for neovascular age-related macular degeneration: a systematic review and economic evaluation Health Technology Assessment systematic review economic evaluation age-related macular degeneration neovascular age-related macular degeneration optical coherence tomography |
| title | Optical coherence tomography for the diagnosis, monitoring and guiding of treatment for neovascular age-related macular degeneration: a systematic review and economic evaluation |
| title_full | Optical coherence tomography for the diagnosis, monitoring and guiding of treatment for neovascular age-related macular degeneration: a systematic review and economic evaluation |
| title_fullStr | Optical coherence tomography for the diagnosis, monitoring and guiding of treatment for neovascular age-related macular degeneration: a systematic review and economic evaluation |
| title_full_unstemmed | Optical coherence tomography for the diagnosis, monitoring and guiding of treatment for neovascular age-related macular degeneration: a systematic review and economic evaluation |
| title_short | Optical coherence tomography for the diagnosis, monitoring and guiding of treatment for neovascular age-related macular degeneration: a systematic review and economic evaluation |
| title_sort | optical coherence tomography for the diagnosis monitoring and guiding of treatment for neovascular age related macular degeneration a systematic review and economic evaluation |
| topic | systematic review economic evaluation age-related macular degeneration neovascular age-related macular degeneration optical coherence tomography |
| url | https://doi.org/10.3310/hta18690 |
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