Lentiviral vectors escape innate sensing but trigger p53 in human hematopoietic stem and progenitor cells

Lentiviral vectors escape innate sensing but trigger p53 in human hematopoietic stem and progenitor cells

Abstract Clinical application of lentiviral vector (LV)‐based hematopoietic stem and progenitor cells (HSPC) gene therapy is rapidly becoming a reality. Nevertheless, LV‐mediated signaling and its potential functional consequences on HSPC biology remain poorly understood. We unravel here a remarkabl...

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Bibliographic Details
Main Authors: Francesco Piras, Michela Riba, Carolina Petrillo, Dejan Lazarevic, Ivan Cuccovillo, Sara Bartolaccini, Elia Stupka, Bernhard Gentner, Davide Cittaro, Luigi Naldini, Anna Kajaste‐Rudnitski
Format: Article
Language:English
Published: Springer Nature 2017-06-01
Series:EMBO Molecular Medicine
Subjects:
gene therapy
hematopoietic stem and progenitor cells
innate sensing
lentiviral vectors
p53 signaling
Online Access:https://doi.org/10.15252/emmm.201707922

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