Notch pathway inhibitor DAPT enhances Atoh1 activity to generate new hair cells in situ in rat cochleae

Notch pathway inhibitor DAPT enhances Atoh1 activity to generate new hair cells in situ in rat cochleae

Atoh1 overexpression in cochlear epithelium induces new hair cell formation. Use of adenovirus-mediated Atoh1 overexpression has mainly focused on the rat lesser epithelial ridge and induces ectopic hair cell regeneration. The sensory region of rat cochlea is difficult to transfect, thus new hair ce...

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Bibliographic Details
Main Authors: Wen-wei Luo, Zhao Han, Dong-dong Ren, Xin-wei Wang, Fang-lu Chi, Juan-mei Yang
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2017-01-01
Series:Neural Regeneration Research
Subjects:
nerve regeneration; Atoh1; DAPT; transdifferentiation; gamma secretase inhibitor; cochlea; sensory epithelium; fetal bovine serum; hair cell; supporting cell; hair cell regeneration; neural regeneration
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=12;spage=2092;epage=2099;aulast=Luo

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