Therapeutic Targets in Chlamydial Fatty Acid and Phospholipid Synthesis

Therapeutic Targets in Chlamydial Fatty Acid and Phospholipid Synthesis

Chlamydia trachomatis is an obligate intracellular pathogen with a reduced genome reflecting its host cell dependent life style. However, C. trachomatis has retained all of the genes required for fatty acid and phospholipid synthesis that are present in free-living bacteria. C. trachomatis assembles...

Full description

Bibliographic Details
Main Authors:	Jiangwei Yao, Charles O. Rock
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-09-01
Series:	Frontiers in Microbiology
Subjects:	Chlamydia fatty acid synthesis phospholipid enoyl-ACP reductase antibiotic target
Online Access:	https://www.frontiersin.org/article/10.3389/fmicb.2018.02291/full

Similar Items

Insilico Analysis of Phytoconstituents from Allium sativum as Potential Inhibitors of Inha in Mycobacterium tuberculosis
by: Rmaraj Kannan, et al.

Design, synthesis, and in vitro biological evaluation of dehydroaripiprazole derivatives as antituberculosis agents and molecular docking study
by: B. Raja Sekhara Reddy, et al.
Published: (2022-01-01)

Function of ORFC of the polyketide synthase gene cluster on fatty acid accumulation in Schizochytrium limacinum SR21
by: Yanyan Shi, et al.
Published: (2021-07-01)

Comparative Modeling and Molecular Dynamics Simulation of Substrate Binding in Human Fatty Acid Synthase: Enoyl Reductase and β-Ketoacyl Reductase Catalytic Domains
by: Arun John, et al.
Published: (2015-03-01)

Single Turnover of Transient of Reactants Supports a Complex Interplay of Conformational States in the Mode of Action of <i>Mycobacterium tuberculosis</i> Enoyl Reductase
by: Leonardo Kras Borges Martinelli, et al.
Published: (2023-03-01)

N-[2-(1H-Indol-3-yl)-1-(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)ethyl]-4-methylbenzenesulfonamide
by: Nikil Purushotham, et al.
Published: (2018-07-01)

Structure-Activity Relationship Modeling and Experimental Validation of the Imidazolium and Pyridinium Based Ionic Liquids as Potential Antibacterials of MDR <i>Acinetobacter baumannii</i> and <i>Staphylococcus aureus</i>
by: Ivan V. Semenyuta, et al.
Published: (2021-01-01)

A Novel Cytosolic Isoform of Mitochondrial Trans-2-Enoyl-CoA Reductase Enhances Peroxisome Proliferator-Activated Receptor α Activity
by: Dong-Gyu Kim, et al.
Published: (2014-06-01)

Improving the binding affinity and interaction of 5-Pentyl-2-Phenoxyphenol against Mycobacterium Enoyl ACP reductase by computational approach
by: Jakaria Shawon, et al.
Published: (2021-01-01)

Production of D6,7-anhidroeritromisin-A from Saccharopolyspora erythraea ATCC 11635 culture
by: Khairan, et al.
Published: (2008-10-01)

Chlamydial Infection-Dependent Synthesis of Sphingomyelin as a Novel Anti-Chlamydial Target of Ceramide Mimetic Compounds
by: Keigo Kumagai, et al.
Published: (2022-11-01)

Synthesis of Dolichols in <i>Candida albicans</i> Is Co-Regulated with Elongation of Fatty Acids
by: Anna Janik, et al.
Published: (2021-12-01)

The Use of Essential Phospholipids for the Treatment of Fatty Liver Disease
by: Yu.M. Stepanov
Published: (2016-11-01)

Characterization of 3-Oxacyl-Acyl Carrier Protein Reductase Homolog Genes in Pseudomonas aeruginosa PAO1
by: Qiao-Qiao Guo, et al.
Published: (2019-05-01)

Fish and amphibians as potential reservoirs of Mycobacterium ulcerans, the causative agent of Buruli ulcer disease
by: Mark Eric Benbow, et al.
Published: (2013-02-01)

Composition of phospholipids and of phospholipid fatty acids and aldehydes in human red cells
by: James T. Dodge, et al.
Published: (1967-11-01)

LIPOSOME STABILITY DEPENDENCE ON FATTY ACID LECITHIN COMPOSITION AND PHOSPHOLIPIDS SUNFLOWER
by: S. M.
Published: (2016-02-01)

In vitro synthesis of phospholipids with yeast phospholipase B, a phospholipid deacylating enzyme
by: Yasuo Watanabe, et al.
Published: (2018-06-01)

Phospholipids/
by: Hawthorne, J. N., et al.
Published: (1982)

Milk phospholipid antioxidant activity and digestibility: Kinetics of fatty acids and choline release
by: Zhiguang Huang, et al.
Published: (2020-05-01)

Synthesis and Antimicrobial Activity Screening of Piperazines Bearing <i>N</i>,<i>N′</i>-Bis(1,3,4-thiadiazole) Moiety as Probable Enoyl-ACP Reductase Inhibitors
by: Alaa Z. Omar, et al.
Published: (2022-06-01)

Navigating the Chemical Space of ENR Inhibitors: A Comprehensive Analysis
by: Vid Kuralt, et al.
Published: (2024-03-01)

Regulation of phospholipid synthesis in yeast
by: George M. Carman, et al.
Published: (2009-01-01)

Laboratory diagnosis of persistent human chlamydial infection
by: Mirja ePuolakkainen, et al.
Published: (2013-12-01)

Fatty acid composition of total lipids and phospholipids of muscular tissue and brain of rats under the impact of vibration
by: N. M. Kostyshyn, et al.
Published: (2016-06-01)

Innovative Phospholipid Carriers: A Viable Strategy to Counteract Antimicrobial Resistance
by: Daria Nicolosi, et al.
Published: (2023-11-01)

Associations between Fatty Acid Intakes and Plasma Phospholipid Fatty Acid Concentrations in the European Prospective Investigation into Cancer and Nutrition
by: Inge Huybrechts, et al.
Published: (2023-08-01)

Gut dysbiosis contributes to chlamydial induction of hydrosalpinx in the upper genital tract
by: Qi Tian, et al.
Published: (2023-04-01)

Phospholipid classes and fatty acid composition of ewe’s and goat’s milk
by: L. Zancada, et al.
Published: (2013-06-01)

Altered lung phospholipid metabolism in mice with targeted deletion of lysosomal-type phospholipase A21
by: Aron B. Fisher, et al.
Published: (2005-06-01)

Influence of dietary fatty acids on phospholipid fatty acid composition in subcellular particles of rat liver
by: A. Yamamoto, et al.
Published: (1965-04-01)

Reactive Chlamydial Arthritis and Ophtalmopathies
by: А.К. Pavliuchenko
Published: (2015-08-01)

Bilayer Forming Phospholipids as Targets for Cancer Therapy
by: Celine Stoica, et al.
Published: (2022-05-01)

Host Fatty Acid Utilization by <named-content content-type="genus-species">Staphylococcus aureus</named-content> at the Infection Site
by: Matthew W. Frank, et al.
Published: (2020-06-01)

Comparison of Egg Yolk and Soybean Phospholipids on Hepatic Fatty Acid Profile and Liver Protection in Rats Fed a High-Fructose Diet
by: Mingyu Yin, et al.
Published: (2021-07-01)

Specific phospholipid fatty acid composition of brain regions in mice: effects of n–3 polyunsaturated fatty acid deficiency and phospholipid supplementation
by: Isabelle Carrié, et al.
Published: (2000-03-01)

ECERIFERUM 10 Encoding an Enoyl-CoA Reductase Plays a Crucial Role in Osmotolerance and Cuticular Wax Loading in Arabidopsis
by: Norika Fukuda, et al.
Published: (2022-06-01)

Differential Diagnosis of Chlamydial Pneumonia Agents “ C. pneumonia and C. psittaci ” by PCR
by: Masoud Hajia, et al.
Published: (1998-09-01)

CHLAMYDIAL INFECTION IN CHILDREN: THE CURRENT STATE OF THE PROBLEM
by: Zhuk L. A.
Published: (2018-12-01)

New and emerging chlamydial infections of creatures great and small
by: A. Taylor-Brown, et al.
Published: (2017-07-01)