Induction of Th17 cell differentiation by B-1 cells
B-1 cells constitute a unique B cell population with distinct ontogenic, phenotypic, and functional characteristics. Naïve, unmanipulated B-1 cells induce differentiation of CD4+ T cells to become pro-inflammatory Th17 cells whereas naïve B-2 cells do not. We examined the role of...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-09-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00281/full |
| _version_ | 1828791024985571328 |
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| author | Yi eWang Thomas L Rothstein |
| author_facet | Yi eWang Thomas L Rothstein |
| author_sort | Yi eWang |
| collection | DOAJ |
| description | B-1 cells constitute a unique B cell population with distinct ontogenic, phenotypic, and functional characteristics. Naïve, unmanipulated B-1 cells induce differentiation of CD4+ T cells to become pro-inflammatory Th17 cells whereas naïve B-2 cells do not. We examined the role of distinctly expressed surface membrane molecules in providing B-1 cells with Th17-differentiating function. Neither Mac-1, CD25, PD-L2 nor CD73 appeared to contribute to B-1 cell induction of Th17 differentiation. In contrast, we found that CD44 and CD86 are involved on the basis of studies with neutralizing antibodies and knock-out mice. Activation imparted to naïve B-2 cells the ability to induce Th17 differentiation and this was similarly partially interrupted by interfering with CD44 and CD86. Our findings suggest that CD44-OPN and B7 family members play important roles in the induction of Th17 cell differentiation by B cells. |
| first_indexed | 2024-12-12T02:43:29Z |
| format | Article |
| id | doaj.art-7e796f516659474ab4f4e08e0faa67d1 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-12T02:43:29Z |
| publishDate | 2012-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-7e796f516659474ab4f4e08e0faa67d12022-12-22T00:41:07ZengFrontiers Media S.A.Frontiers in Immunology1664-32242012-09-01310.3389/fimmu.2012.0028131402Induction of Th17 cell differentiation by B-1 cellsYi eWang0Thomas L Rothstein1Feinstein institute for medical researchFeinstein institute for medical researchB-1 cells constitute a unique B cell population with distinct ontogenic, phenotypic, and functional characteristics. Naïve, unmanipulated B-1 cells induce differentiation of CD4+ T cells to become pro-inflammatory Th17 cells whereas naïve B-2 cells do not. We examined the role of distinctly expressed surface membrane molecules in providing B-1 cells with Th17-differentiating function. Neither Mac-1, CD25, PD-L2 nor CD73 appeared to contribute to B-1 cell induction of Th17 differentiation. In contrast, we found that CD44 and CD86 are involved on the basis of studies with neutralizing antibodies and knock-out mice. Activation imparted to naïve B-2 cells the ability to induce Th17 differentiation and this was similarly partially interrupted by interfering with CD44 and CD86. Our findings suggest that CD44-OPN and B7 family members play important roles in the induction of Th17 cell differentiation by B cells.http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00281/fullB-1 cellsTh17CD44B-2 cellsCD86 |
| spellingShingle | Yi eWang Thomas L Rothstein Induction of Th17 cell differentiation by B-1 cells Frontiers in Immunology B-1 cells Th17 CD44 B-2 cells CD86 |
| title | Induction of Th17 cell differentiation by B-1 cells |
| title_full | Induction of Th17 cell differentiation by B-1 cells |
| title_fullStr | Induction of Th17 cell differentiation by B-1 cells |
| title_full_unstemmed | Induction of Th17 cell differentiation by B-1 cells |
| title_short | Induction of Th17 cell differentiation by B-1 cells |
| title_sort | induction of th17 cell differentiation by b 1 cells |
| topic | B-1 cells Th17 CD44 B-2 cells CD86 |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00281/full |
| work_keys_str_mv | AT yiewang inductionofth17celldifferentiationbyb1cells AT thomaslrothstein inductionofth17celldifferentiationbyb1cells |