Comparison of Kindlin-2 deficiency-stimulated osteoarthritis-like lesions induced by Prg4CreERT2 versus AggrecanCreERT2 transgene in mice

Comparison of Kindlin-2 deficiency-stimulated osteoarthritis-like lesions induced by Prg4CreERT2 versus AggrecanCreERT2 transgene in mice

Background: Genetically modified mice are the most useful tools for investigating the gene functions in articular cartilage biology and the pathogenesis of osteoarthritis. The AggrecanCreERT2 mice are one of the most reported mouse lines used for this purpose. The Prg4 (proteoglycan 4) gene encodes...

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Bibliographic Details
Main Authors: Qing Yao, Weiyuan Gong, Xiaohao Wu, Donghao Gan, Chu Tao, Sixiong Lin, Minghao Qu, Zhongtian Ouyang, Mingjue Chen, Xinjia Hu, Guozhi Xiao
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Journal of Orthopaedic Translation
Subjects:
Articular chondrocyte
Osteoarthritis
Kindlin-2
Prg4GFPCreERT2
AggrecanCreERT2
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X23000323

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