3D-Conformal Radiation Therapy and Intensity-Modulated Radiation Therapy Techniques for Laryngeal Cancer Taking Parotid Glands as Organ at Risk
<strong>Background: </strong>Three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT) techniques are used for the treatment of patients with laryngeal cancer.<br /> <strong>Objective: </strong>This study aimed to investigate the effe...
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| Format: | Article |
| Language: | English |
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Baqiyatallah University of Medical Sciences
2020-03-01
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| Series: | Hospital Practices and Research |
| Subjects: | |
| Online Access: | http://www.jhpr.ir/article_103995_e87d8094175ac4cea9afb7ca35f97f1f.pdf |
| _version_ | 1818033526405070848 |
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| author | Dler K. Ismael Fatiheea F. Hassan |
| author_facet | Dler K. Ismael Fatiheea F. Hassan |
| author_sort | Dler K. Ismael |
| collection | DOAJ |
| description | <strong>Background: </strong>Three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT) techniques are used for the treatment of patients with laryngeal cancer.<br /> <strong>Objective: </strong>This study aimed to investigate the effects of these 2 treatment techniques on the planning target volume (PTV) (laryngeal cancer), dose homogeneity, dose of organs at risk (OARs) (parotid glands), and conformity index.<br /> <strong>Methods: </strong>This study compared 2 treatment techniques and was conducted from October 2018 to April 2019 at the Zhianawa Cancer Center (ZCC), Sulaimaniyah, Iraq. Eight patients with laryngeal cancer were selected for this study. 3D-CRT and IMRT were used to produce the maximum dose of target volume coverage and minimum dose to the parotid glands. Elekta synergy with a photon beam of 6 MV was used for all measurements. Data analysis was performed using the available statistical package of SPSS 25.<br /> <strong>Results: </strong>The comparison of 3D-CRT with IMRT showed that the mean conformity index value for IMRT was more conformal than the 3D-CRT plan (0.956, 0.945, respectively), but the homogeneity index was better with 3D-CRT than with IMRT (0.175, 0.202, respectively). The mean dose for Rt. parotid glands was higher with IMRT than with 3D-CRT (232.71, 23.26, respectively), and in both plans the mean dose was less than 26 Gy (the standard tolerance value). While in the Lt. parotid gland the mean dose was higher with 3D-CRT than with IMRT (26.95, 23.71, respectively), the mean dose with 3D-CRT was greater than 26 Gy. The amount of PTV was significantly greater with the IMRT technique than with 3D-CRT (52.15±1.61, 51.09.4±0.74 Gy, respectively).<br /> <strong>Conclusion: </strong>This study further supports that IMRT has improved the long-term quality of life of patients with laryngeal cancer. |
| first_indexed | 2024-12-10T06:24:40Z |
| format | Article |
| id | doaj.art-7e7bc931da7146838c00dc1e414e603b |
| institution | Directory Open Access Journal |
| issn | 2476-390X 2476-3918 |
| language | English |
| last_indexed | 2024-12-10T06:24:40Z |
| publishDate | 2020-03-01 |
| publisher | Baqiyatallah University of Medical Sciences |
| record_format | Article |
| series | Hospital Practices and Research |
| spelling | doaj.art-7e7bc931da7146838c00dc1e414e603b2022-12-22T01:59:15ZengBaqiyatallah University of Medical SciencesHospital Practices and Research2476-390X2476-39182020-03-0151101610.34172/hpr.2020.031039953D-Conformal Radiation Therapy and Intensity-Modulated Radiation Therapy Techniques for Laryngeal Cancer Taking Parotid Glands as Organ at RiskDler K. Ismael0Fatiheea F. Hassan1Department of Basic Sciences, College of Medicine, Hawler Medical University, Erbil, IraqDepartment of Basic Sciences, College of Medicine, Hawler Medical University, Erbil, Iraq<strong>Background: </strong>Three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT) techniques are used for the treatment of patients with laryngeal cancer.<br /> <strong>Objective: </strong>This study aimed to investigate the effects of these 2 treatment techniques on the planning target volume (PTV) (laryngeal cancer), dose homogeneity, dose of organs at risk (OARs) (parotid glands), and conformity index.<br /> <strong>Methods: </strong>This study compared 2 treatment techniques and was conducted from October 2018 to April 2019 at the Zhianawa Cancer Center (ZCC), Sulaimaniyah, Iraq. Eight patients with laryngeal cancer were selected for this study. 3D-CRT and IMRT were used to produce the maximum dose of target volume coverage and minimum dose to the parotid glands. Elekta synergy with a photon beam of 6 MV was used for all measurements. Data analysis was performed using the available statistical package of SPSS 25.<br /> <strong>Results: </strong>The comparison of 3D-CRT with IMRT showed that the mean conformity index value for IMRT was more conformal than the 3D-CRT plan (0.956, 0.945, respectively), but the homogeneity index was better with 3D-CRT than with IMRT (0.175, 0.202, respectively). The mean dose for Rt. parotid glands was higher with IMRT than with 3D-CRT (232.71, 23.26, respectively), and in both plans the mean dose was less than 26 Gy (the standard tolerance value). While in the Lt. parotid gland the mean dose was higher with 3D-CRT than with IMRT (26.95, 23.71, respectively), the mean dose with 3D-CRT was greater than 26 Gy. The amount of PTV was significantly greater with the IMRT technique than with 3D-CRT (52.15±1.61, 51.09.4±0.74 Gy, respectively).<br /> <strong>Conclusion: </strong>This study further supports that IMRT has improved the long-term quality of life of patients with laryngeal cancer.http://www.jhpr.ir/article_103995_e87d8094175ac4cea9afb7ca35f97f1f.pdfradiotherapyconformalintensity-modulatedorgans at risklaryngeal cancer |
| spellingShingle | Dler K. Ismael Fatiheea F. Hassan 3D-Conformal Radiation Therapy and Intensity-Modulated Radiation Therapy Techniques for Laryngeal Cancer Taking Parotid Glands as Organ at Risk Hospital Practices and Research radiotherapy conformal intensity-modulated organs at risk laryngeal cancer |
| title | 3D-Conformal Radiation Therapy and Intensity-Modulated Radiation Therapy Techniques for Laryngeal Cancer Taking Parotid Glands as Organ at Risk |
| title_full | 3D-Conformal Radiation Therapy and Intensity-Modulated Radiation Therapy Techniques for Laryngeal Cancer Taking Parotid Glands as Organ at Risk |
| title_fullStr | 3D-Conformal Radiation Therapy and Intensity-Modulated Radiation Therapy Techniques for Laryngeal Cancer Taking Parotid Glands as Organ at Risk |
| title_full_unstemmed | 3D-Conformal Radiation Therapy and Intensity-Modulated Radiation Therapy Techniques for Laryngeal Cancer Taking Parotid Glands as Organ at Risk |
| title_short | 3D-Conformal Radiation Therapy and Intensity-Modulated Radiation Therapy Techniques for Laryngeal Cancer Taking Parotid Glands as Organ at Risk |
| title_sort | 3d conformal radiation therapy and intensity modulated radiation therapy techniques for laryngeal cancer taking parotid glands as organ at risk |
| topic | radiotherapy conformal intensity-modulated organs at risk laryngeal cancer |
| url | http://www.jhpr.ir/article_103995_e87d8094175ac4cea9afb7ca35f97f1f.pdf |
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