Investigating the potential of oncolytic viruses for cancer treatment via MSC delivery
Abstract Mesenchymal stem cells (MSCs) have attracted considerable interest as a promising approach for cancer treatment due to their ability to undergo tumor-trophic migration. MSCs possess the unique ability to selectively migrate to tumors, making them an excellent candidate for targeted delivery...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | Cell Communication and Signaling |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12964-023-01232-y |
| _version_ | 1797557724522741760 |
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| author | Hadi Esmaeili Gouvarchin Ghaleh Gazal Vakilzadeh Ali Zahiri Mahdieh Farzanehpour |
| author_facet | Hadi Esmaeili Gouvarchin Ghaleh Gazal Vakilzadeh Ali Zahiri Mahdieh Farzanehpour |
| author_sort | Hadi Esmaeili Gouvarchin Ghaleh |
| collection | DOAJ |
| description | Abstract Mesenchymal stem cells (MSCs) have attracted considerable interest as a promising approach for cancer treatment due to their ability to undergo tumor-trophic migration. MSCs possess the unique ability to selectively migrate to tumors, making them an excellent candidate for targeted delivery of oncolytic viruses (OVs) to treat isolated tumors and metastatic malignancies. OVs have attracted attention as a potential treatment for cancer due to their ability to selectively infect and destroy tumor cells while sparing normal cells. In addition, OVs can induce immunogenic cell death and contain curative transgenes in their genome, making them an attractive candidate for cancer treatment in combination with immunotherapies. In combination with MSCs, OVs can modulate the tumor microenvironment and trigger anti-tumor immune responses, making MSC-releasing OVs a promising approach for cancer treatment. This study reviews researches on the use of MSC-released OVs as a novel method for treating cancer. Graphical Abstract Video Abstract |
| first_indexed | 2024-03-10T17:20:21Z |
| format | Article |
| id | doaj.art-7e7c0343211649a3a0d4062f56c48fef |
| institution | Directory Open Access Journal |
| issn | 1478-811X |
| language | English |
| last_indexed | 2024-03-10T17:20:21Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj.art-7e7c0343211649a3a0d4062f56c48fef2023-11-20T10:21:44ZengBMCCell Communication and Signaling1478-811X2023-09-0121111110.1186/s12964-023-01232-yInvestigating the potential of oncolytic viruses for cancer treatment via MSC deliveryHadi Esmaeili Gouvarchin Ghaleh0Gazal Vakilzadeh1Ali Zahiri2Mahdieh Farzanehpour3Applied Virology Research Center, Baqiyatallah University of Medical sciencesApplied Virology Research Center, Baqiyatallah University of Medical sciencesStudents Research Committee, Baqiyatallah University of Medical SciencesApplied Virology Research Center, Baqiyatallah University of Medical sciencesAbstract Mesenchymal stem cells (MSCs) have attracted considerable interest as a promising approach for cancer treatment due to their ability to undergo tumor-trophic migration. MSCs possess the unique ability to selectively migrate to tumors, making them an excellent candidate for targeted delivery of oncolytic viruses (OVs) to treat isolated tumors and metastatic malignancies. OVs have attracted attention as a potential treatment for cancer due to their ability to selectively infect and destroy tumor cells while sparing normal cells. In addition, OVs can induce immunogenic cell death and contain curative transgenes in their genome, making them an attractive candidate for cancer treatment in combination with immunotherapies. In combination with MSCs, OVs can modulate the tumor microenvironment and trigger anti-tumor immune responses, making MSC-releasing OVs a promising approach for cancer treatment. This study reviews researches on the use of MSC-released OVs as a novel method for treating cancer. Graphical Abstract Video Abstracthttps://doi.org/10.1186/s12964-023-01232-yMesenchymal stem cellsOncolytic virusesTumor microenvironmentImmunotherapy |
| spellingShingle | Hadi Esmaeili Gouvarchin Ghaleh Gazal Vakilzadeh Ali Zahiri Mahdieh Farzanehpour Investigating the potential of oncolytic viruses for cancer treatment via MSC delivery Cell Communication and Signaling Mesenchymal stem cells Oncolytic viruses Tumor microenvironment Immunotherapy |
| title | Investigating the potential of oncolytic viruses for cancer treatment via MSC delivery |
| title_full | Investigating the potential of oncolytic viruses for cancer treatment via MSC delivery |
| title_fullStr | Investigating the potential of oncolytic viruses for cancer treatment via MSC delivery |
| title_full_unstemmed | Investigating the potential of oncolytic viruses for cancer treatment via MSC delivery |
| title_short | Investigating the potential of oncolytic viruses for cancer treatment via MSC delivery |
| title_sort | investigating the potential of oncolytic viruses for cancer treatment via msc delivery |
| topic | Mesenchymal stem cells Oncolytic viruses Tumor microenvironment Immunotherapy |
| url | https://doi.org/10.1186/s12964-023-01232-y |
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