A review on the evidence of transgenerational transmission of posttraumatic stress disorder vulnerability
Objective: To understand the risks of posttraumatic stress disorder (PTSD) development in the next generation of PTSD patients, we conducted a review on the biological, but not genetic, evidence of transgenerational transmission of PTSD vulnerability. Methods: Pertinent articles published from 1985...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Psiquiatria (ABP)
2014-03-01
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| Series: | Brazilian Journal of Psychiatry |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462014000100014&lng=en&tlng=en |
| _version_ | 1819131080041562112 |
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| author | Seyyed Taha Yahyavi Mehran Zarghami Urvashi Marwah |
| author_facet | Seyyed Taha Yahyavi Mehran Zarghami Urvashi Marwah |
| author_sort | Seyyed Taha Yahyavi |
| collection | DOAJ |
| description | Objective: To understand the risks of posttraumatic stress disorder (PTSD) development in the next generation of PTSD patients, we conducted a review on the biological, but not genetic, evidence of transgenerational transmission of PTSD vulnerability. Methods: Pertinent articles published from 1985 to September 2011 were searched using online academic search engines, including MEDLINE, EMBASE, ScienceDirect, OVID, PsycLIT, and SCOPUS, and a non-systematic review was conducted. Results: There is paradoxical evidence that hypothalamic-pituitary-adrenal axis changes in PTSD patients may also be evident in their offspring. This effect and biological vulnerability to PTSD may be transmitted across generations through maternal epigenetic programming during pregnancy. The samples of most studies, which were not large enough and represented the outcome of few research groups, consisted of a specific type of patients with a particular trauma. Conclusions: There is still a need to conduct studies in other geographical areas with different genetic background and larger samples considering different types of trauma other than those specified in the current literature, so as to strengthen the evidence of transgenerational transmission of PTSD vulnerability. |
| first_indexed | 2024-12-22T09:09:49Z |
| format | Article |
| id | doaj.art-7e7e7434c95746a19c653fee2648bfff |
| institution | Directory Open Access Journal |
| issn | 1809-452X |
| language | English |
| last_indexed | 2024-12-22T09:09:49Z |
| publishDate | 2014-03-01 |
| publisher | Associação Brasileira de Psiquiatria (ABP) |
| record_format | Article |
| series | Brazilian Journal of Psychiatry |
| spelling | doaj.art-7e7e7434c95746a19c653fee2648bfff2022-12-21T18:31:29ZengAssociação Brasileira de Psiquiatria (ABP)Brazilian Journal of Psychiatry1809-452X2014-03-01361899410.1590/1516-4446-2012-0995S1516-44462014000100014A review on the evidence of transgenerational transmission of posttraumatic stress disorder vulnerabilitySeyyed Taha YahyaviMehran ZarghamiUrvashi MarwahObjective: To understand the risks of posttraumatic stress disorder (PTSD) development in the next generation of PTSD patients, we conducted a review on the biological, but not genetic, evidence of transgenerational transmission of PTSD vulnerability. Methods: Pertinent articles published from 1985 to September 2011 were searched using online academic search engines, including MEDLINE, EMBASE, ScienceDirect, OVID, PsycLIT, and SCOPUS, and a non-systematic review was conducted. Results: There is paradoxical evidence that hypothalamic-pituitary-adrenal axis changes in PTSD patients may also be evident in their offspring. This effect and biological vulnerability to PTSD may be transmitted across generations through maternal epigenetic programming during pregnancy. The samples of most studies, which were not large enough and represented the outcome of few research groups, consisted of a specific type of patients with a particular trauma. Conclusions: There is still a need to conduct studies in other geographical areas with different genetic background and larger samples considering different types of trauma other than those specified in the current literature, so as to strengthen the evidence of transgenerational transmission of PTSD vulnerability.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462014000100014&lng=en&tlng=enPosttraumatic stress disorderbiological markersneuroendocrinologystressviolence/aggression |
| spellingShingle | Seyyed Taha Yahyavi Mehran Zarghami Urvashi Marwah A review on the evidence of transgenerational transmission of posttraumatic stress disorder vulnerability Brazilian Journal of Psychiatry Posttraumatic stress disorder biological markers neuroendocrinology stress violence/aggression |
| title | A review on the evidence of transgenerational transmission of posttraumatic stress disorder vulnerability |
| title_full | A review on the evidence of transgenerational transmission of posttraumatic stress disorder vulnerability |
| title_fullStr | A review on the evidence of transgenerational transmission of posttraumatic stress disorder vulnerability |
| title_full_unstemmed | A review on the evidence of transgenerational transmission of posttraumatic stress disorder vulnerability |
| title_short | A review on the evidence of transgenerational transmission of posttraumatic stress disorder vulnerability |
| title_sort | review on the evidence of transgenerational transmission of posttraumatic stress disorder vulnerability |
| topic | Posttraumatic stress disorder biological markers neuroendocrinology stress violence/aggression |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462014000100014&lng=en&tlng=en |
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