The Use of Values WNR and GNR to Distinguish between and Diagnose Different Types of Pancreatitis
There is no effective serologic parameter to distinguish different types of pancreatitis now. To distinguish between acute pancreatitis (AP) and acute exacerbations of chronic pancreatitis (CP) and to determine whether fibrosis occurs in CP, we evaluated the ability to produce white blood cells (WBC...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-09-01
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| Series: | Molecular Therapy: Methods & Clinical Development |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2329050120300978 |
| _version_ | 1811310430020173824 |
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| author | Liwen Luo Junfeng Zhang Jiali Yang Hongyu Zhang Yichen Tang Di Yang Hui Dong Yuzhang Wu Huaizhi Wang Bing Ni Zhiqiang Tian |
| author_facet | Liwen Luo Junfeng Zhang Jiali Yang Hongyu Zhang Yichen Tang Di Yang Hui Dong Yuzhang Wu Huaizhi Wang Bing Ni Zhiqiang Tian |
| author_sort | Liwen Luo |
| collection | DOAJ |
| description | There is no effective serologic parameter to distinguish different types of pancreatitis now. To distinguish between acute pancreatitis (AP) and acute exacerbations of chronic pancreatitis (CP) and to determine whether fibrosis occurs in CP, we evaluated the ability to produce white blood cells (WBCs), the neutrophil-to-retinol-binding protein (RBP) ratio (called the WNR), the product of the gamma-glutamyl transpeptidase (GGT) level, and the 5′-nucleotide-to-RBP ratio (called the GNR). We evaluated the newly proposed difference index RBP and analyzed the effectiveness of the WNR and GNR in 691 patients with pancreatic diseases. We performed univariate and multivariate analyses of serological indices and their correlations with RBP and performed receiver operating characteristic (ROC) curve analyses of the WNR and GNR. The serum RBP level decreased markedly in AP compared with that in the acute stage of CP (p < 0.05). The GGT, alkaline phosphatase (ALP), total protein (TP), albumin (ALB), prealbumin (PA), 5′-nucleotide, and uric acid (UC) serum levels were significantly higher for fibrotic CP than for the acute stage of CP without fibrosis (p < 0.05). With progressing to pancreatic fibrosis, the liver injury-related indicators, prothrombin time (PT), activated partial thromboplastin time (APTT), D-Dimer, aspartate aminotransferase (AST), and GGT, gradually increased (p < 0.05). ROC curve analysis suggests that both the WNR (area under the curve [AUC] = 0.821) and GNR (AUC = 0.778) can be used to differentiate pancreatitis types. |
| first_indexed | 2024-04-13T09:58:37Z |
| format | Article |
| id | doaj.art-7e8047445e574968ae2c103dad4b5696 |
| institution | Directory Open Access Journal |
| issn | 2329-0501 |
| language | English |
| last_indexed | 2024-04-13T09:58:37Z |
| publishDate | 2020-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Molecular Therapy: Methods & Clinical Development |
| spelling | doaj.art-7e8047445e574968ae2c103dad4b56962022-12-22T02:51:17ZengElsevierMolecular Therapy: Methods & Clinical Development2329-05012020-09-0118714The Use of Values WNR and GNR to Distinguish between and Diagnose Different Types of PancreatitisLiwen Luo0Junfeng Zhang1Jiali Yang2Hongyu Zhang3Yichen Tang4Di Yang5Hui Dong6Yuzhang Wu7Huaizhi Wang8Bing Ni9Zhiqiang Tian10Institute of Immunology, PLA, Army Medical University, Chongqing 400038, China; Institute of Hepatopancreatobiliary Surgery, Southwest Hospital, Army Medical University, Chongqing, ChinaInstitute of Hepatopancreatobiliary Surgery, Southwest Hospital, Army Medical University, Chongqing, China; Institute of Hepatopancreatobiliary Surgery, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing 401121, ChinaInstitute of Hepatopancreatobiliary Surgery, Southwest Hospital, Army Medical University, Chongqing, ChinaDepartment of Emergency, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Hepatobiliary Surgery, Xinqiao Hospital, Army Medical University, Chongqing, ChinaInstitute of Immunology, PLA, Army Medical University, Chongqing 400038, ChinaInstitute of Immunology, PLA, Army Medical University, Chongqing 400038, ChinaInstitute of Immunology, PLA, Army Medical University, Chongqing 400038, China; Corresponding author: Yuzhang Wu, Institute of Immunology, PLA, Army Medical University, Chongqing 400038, China.Institute of Hepatopancreatobiliary Surgery, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing 401121, China; Corresponding author: Huaizhi Wang, Institute of Hepatopancreatobiliary Surgery, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing 401121, China.Institute of Immunology, PLA, Army Medical University, Chongqing 400038, China; Department of Pathophysiology, College of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, PR China; Corresponding author: Bing Ni, Institute of Immunology, PLA, Army Medical University, Chongqing 400038, China.Institute of Immunology, PLA, Army Medical University, Chongqing 400038, China; Biological Science Research Center, Southwest University, Chongqing, China; Corresponding author: Zhiqiang Tian, Institute of Immunology, PLA, Army Medical University, Chongqing 400038, China.There is no effective serologic parameter to distinguish different types of pancreatitis now. To distinguish between acute pancreatitis (AP) and acute exacerbations of chronic pancreatitis (CP) and to determine whether fibrosis occurs in CP, we evaluated the ability to produce white blood cells (WBCs), the neutrophil-to-retinol-binding protein (RBP) ratio (called the WNR), the product of the gamma-glutamyl transpeptidase (GGT) level, and the 5′-nucleotide-to-RBP ratio (called the GNR). We evaluated the newly proposed difference index RBP and analyzed the effectiveness of the WNR and GNR in 691 patients with pancreatic diseases. We performed univariate and multivariate analyses of serological indices and their correlations with RBP and performed receiver operating characteristic (ROC) curve analyses of the WNR and GNR. The serum RBP level decreased markedly in AP compared with that in the acute stage of CP (p < 0.05). The GGT, alkaline phosphatase (ALP), total protein (TP), albumin (ALB), prealbumin (PA), 5′-nucleotide, and uric acid (UC) serum levels were significantly higher for fibrotic CP than for the acute stage of CP without fibrosis (p < 0.05). With progressing to pancreatic fibrosis, the liver injury-related indicators, prothrombin time (PT), activated partial thromboplastin time (APTT), D-Dimer, aspartate aminotransferase (AST), and GGT, gradually increased (p < 0.05). ROC curve analysis suggests that both the WNR (area under the curve [AUC] = 0.821) and GNR (AUC = 0.778) can be used to differentiate pancreatitis types.http://www.sciencedirect.com/science/article/pii/S2329050120300978pancreatitisWNRGNRpancreatic fibrosis |
| spellingShingle | Liwen Luo Junfeng Zhang Jiali Yang Hongyu Zhang Yichen Tang Di Yang Hui Dong Yuzhang Wu Huaizhi Wang Bing Ni Zhiqiang Tian The Use of Values WNR and GNR to Distinguish between and Diagnose Different Types of Pancreatitis Molecular Therapy: Methods & Clinical Development pancreatitis WNR GNR pancreatic fibrosis |
| title | The Use of Values WNR and GNR to Distinguish between and Diagnose Different Types of Pancreatitis |
| title_full | The Use of Values WNR and GNR to Distinguish between and Diagnose Different Types of Pancreatitis |
| title_fullStr | The Use of Values WNR and GNR to Distinguish between and Diagnose Different Types of Pancreatitis |
| title_full_unstemmed | The Use of Values WNR and GNR to Distinguish between and Diagnose Different Types of Pancreatitis |
| title_short | The Use of Values WNR and GNR to Distinguish between and Diagnose Different Types of Pancreatitis |
| title_sort | use of values wnr and gnr to distinguish between and diagnose different types of pancreatitis |
| topic | pancreatitis WNR GNR pancreatic fibrosis |
| url | http://www.sciencedirect.com/science/article/pii/S2329050120300978 |
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