IqgC is a potent regulator of macropinocytosis in the presence of NF1 and its loading to macropinosomes is dependent on RasG

IqgC is a potent regulator of macropinocytosis in the presence of NF1 and its loading to macropinosomes is dependent on RasG

RasG is a major regulator of macropinocytosis in Dictyostelium discoideum. Its activity is under the control of an IQGAP-related protein, IqgC, which acts as a RasG-specific GAP (GTPase activating protein). IqgC colocalizes with the active Ras at the macropinosome membrane during its formation and f...

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Bibliographic Details
Main Authors: Darija Putar, Anja Čizmar, Xiaoting Chao, Marija Šimić, Marko Šoštar, Tamara Ćutić, Lucija Mijanović, Ana Smolko, Hui Tu, Pierre Cosson, Igor Weber, Huaqing Cai, Vedrana Filić
Format: Article
Language:English
Published: The Royal Society 2024-01-01
Series:Open Biology
Subjects:
IqgC
Ras
NF1
Rab5
macropinocytosis
Dictyostelium
Online Access:https://royalsocietypublishing.org/doi/10.1098/rsob.230372

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