Serum level of high sensitive C-reactive protein and IL − 6 markers in patients with treatment-resistant schizophrenia in Ethiopia: a comparative study
Abstract Background Accumulating evidence indicates that schizophrenia is accompanied by significant activation of the immune system; however, there is limited data from low and middle-income countries (LMIC). Inflammatory markers may be more relevant in LMIC settings where infectious conditions are...
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| Language: | English |
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BMC
2021-08-01
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| Series: | BMC Psychiatry |
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| Online Access: | https://doi.org/10.1186/s12888-021-03443-4 |
| _version_ | 1818729801980051456 |
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| author | Feyissa Challa Daniel Seifu Meron Sileshi Tigist Getahun Zeleke Geto Desta Kassa Melkam Alemayehu Miraf Mesfin Abebaw Fekadu Yimtubezinash Woldeamanuel |
| author_facet | Feyissa Challa Daniel Seifu Meron Sileshi Tigist Getahun Zeleke Geto Desta Kassa Melkam Alemayehu Miraf Mesfin Abebaw Fekadu Yimtubezinash Woldeamanuel |
| author_sort | Feyissa Challa |
| collection | DOAJ |
| description | Abstract Background Accumulating evidence indicates that schizophrenia is accompanied by significant activation of the immune system; however, there is limited data from low and middle-income countries (LMIC). Inflammatory markers may be more relevant in LMIC settings where infectious conditions are more prevalent and may thus play some role in the causation and maintenance of schizophrenia. The aim of this study was to assess the level of inflammatory markers high sensitive C-reactive protein (hsCRP) and interleukin-6 (IL-6) in patients with schizophrenia. Materials and methods The study population consisted of a total of 132 study participants; 82 participants with schizophrenia and 50 controls. hsCRP and IL-6 were measured using Cobas Integra 400 Plus and Cobas e 411 analysers respectively. Results The levels of hsCRP and IL-6 were significantly increased among participants with schizophrenia compared to controls: hsCRP mean value 2.87 ± 5.6 vs 0.67 ± 0.6 mg/L; IL-6 mean value 6.63 ± 5.6 vs 3.37 ± 4.0 pg/ml. Controlling for potential confounders (age, sex and body mass index), having a diagnosis of schizophrenia remained significantly associated with increased hsCRP and IL-6. Conclusion The results confirm that inflammatory processes may have a role in the pathophysiology of schizophrenia regardless of setting. Despite failure of some interventions with anti-inflammatory properties, interventions to reduce inflammation are still worth pursuing. |
| first_indexed | 2024-12-17T22:51:40Z |
| format | Article |
| id | doaj.art-7e842cbb44004aadb497809f539973c0 |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-12-17T22:51:40Z |
| publishDate | 2021-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-7e842cbb44004aadb497809f539973c02022-12-21T21:29:39ZengBMCBMC Psychiatry1471-244X2021-08-012111810.1186/s12888-021-03443-4Serum level of high sensitive C-reactive protein and IL − 6 markers in patients with treatment-resistant schizophrenia in Ethiopia: a comparative studyFeyissa Challa0Daniel Seifu1Meron Sileshi2Tigist Getahun3Zeleke Geto4Desta Kassa5Melkam Alemayehu6Miraf Mesfin7Abebaw Fekadu8Yimtubezinash Woldeamanuel9National References Laboratory for Clinical Chemistry, Ethiopian Public Health InstituteDivision of Basic Sciences, University of Global Health EquityNational References Laboratory for Clinical Chemistry, Ethiopian Public Health InstituteNational References Laboratory for Clinical Chemistry, Ethiopian Public Health InstituteNational References Laboratory for Clinical Chemistry, Ethiopian Public Health InstituteHIV/AIDS and Tuberculosis Research Directorate, Ethiopian Public Health InstituteDepartment of Psychiatry, School of Medicine, College of Health Sciences, Addis Ababa UniversityCentre for Innovative Drug Development and Therapeutic Trials for Africa (CDT-Africa), College of Health Sciences, Addis Ababa UniversityDepartment of Psychiatry, School of Medicine, College of Health Sciences, Addis Ababa UniversityCentre for Innovative Drug Development and Therapeutic Trials for Africa (CDT-Africa), College of Health Sciences, Addis Ababa UniversityAbstract Background Accumulating evidence indicates that schizophrenia is accompanied by significant activation of the immune system; however, there is limited data from low and middle-income countries (LMIC). Inflammatory markers may be more relevant in LMIC settings where infectious conditions are more prevalent and may thus play some role in the causation and maintenance of schizophrenia. The aim of this study was to assess the level of inflammatory markers high sensitive C-reactive protein (hsCRP) and interleukin-6 (IL-6) in patients with schizophrenia. Materials and methods The study population consisted of a total of 132 study participants; 82 participants with schizophrenia and 50 controls. hsCRP and IL-6 were measured using Cobas Integra 400 Plus and Cobas e 411 analysers respectively. Results The levels of hsCRP and IL-6 were significantly increased among participants with schizophrenia compared to controls: hsCRP mean value 2.87 ± 5.6 vs 0.67 ± 0.6 mg/L; IL-6 mean value 6.63 ± 5.6 vs 3.37 ± 4.0 pg/ml. Controlling for potential confounders (age, sex and body mass index), having a diagnosis of schizophrenia remained significantly associated with increased hsCRP and IL-6. Conclusion The results confirm that inflammatory processes may have a role in the pathophysiology of schizophrenia regardless of setting. Despite failure of some interventions with anti-inflammatory properties, interventions to reduce inflammation are still worth pursuing.https://doi.org/10.1186/s12888-021-03443-4SchizophreniaInterleukin-6 (IL-6)High sensitive C - reactive protein (hsCRP)Inflammatory markersEthiopia |
| spellingShingle | Feyissa Challa Daniel Seifu Meron Sileshi Tigist Getahun Zeleke Geto Desta Kassa Melkam Alemayehu Miraf Mesfin Abebaw Fekadu Yimtubezinash Woldeamanuel Serum level of high sensitive C-reactive protein and IL − 6 markers in patients with treatment-resistant schizophrenia in Ethiopia: a comparative study BMC Psychiatry Schizophrenia Interleukin-6 (IL-6) High sensitive C - reactive protein (hsCRP) Inflammatory markers Ethiopia |
| title | Serum level of high sensitive C-reactive protein and IL − 6 markers in patients with treatment-resistant schizophrenia in Ethiopia: a comparative study |
| title_full | Serum level of high sensitive C-reactive protein and IL − 6 markers in patients with treatment-resistant schizophrenia in Ethiopia: a comparative study |
| title_fullStr | Serum level of high sensitive C-reactive protein and IL − 6 markers in patients with treatment-resistant schizophrenia in Ethiopia: a comparative study |
| title_full_unstemmed | Serum level of high sensitive C-reactive protein and IL − 6 markers in patients with treatment-resistant schizophrenia in Ethiopia: a comparative study |
| title_short | Serum level of high sensitive C-reactive protein and IL − 6 markers in patients with treatment-resistant schizophrenia in Ethiopia: a comparative study |
| title_sort | serum level of high sensitive c reactive protein and il 6 markers in patients with treatment resistant schizophrenia in ethiopia a comparative study |
| topic | Schizophrenia Interleukin-6 (IL-6) High sensitive C - reactive protein (hsCRP) Inflammatory markers Ethiopia |
| url | https://doi.org/10.1186/s12888-021-03443-4 |
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