The profile of the expression of the immune response genes in the vagina of women in the complex therapy of recurrent vulvovaginal candidiasis
Host immunity against Candida albicans is crucial in controlling C. albicans infection. The innate immunity is believed to be the first line of host defense, such as the direct killing of yeasts through phagocytosis by neutrophils and macrophages. In addition to innate immune cells, an adjunctive pro...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
IP Berlin A.V.
2017-06-01
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| Series: | Гинекология |
| Subjects: | |
| Online Access: | https://gynecology.orscience.ru/2079-5831/article/viewFile/28627/pdf |
| _version_ | 1818210616146395136 |
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| author | Sh M Pogosyan E A Mezhevitinova P R Abakarova A E Donnikov V V Muravyova |
| author_facet | Sh M Pogosyan E A Mezhevitinova P R Abakarova A E Donnikov V V Muravyova |
| author_sort | Sh M Pogosyan |
| collection | DOAJ |
| description | Host immunity against Candida albicans is crucial in controlling C. albicans infection. The innate immunity is believed to be the first line of host defense, such as the direct killing of yeasts through phagocytosis by neutrophils and macrophages. In addition to innate immune cells, an adjunctive protective effect is played by cellular adaptive immunity represented by Th lymphocytes. The balance of various Th cell subpopulations plays a crucial role in regulating the prognosis of C. albicans infection. Yeasts cell recognition by pattern recognition receptors leads to proinflammatory cytokines synthesis, cause immune system activation and yeast cells killing. However it was demonstrated that C. albicans inhibits immune response which cause infection. Aim - studying vaginal microbiota and the local immune response in women with recurrent vulvovaginal candidiasis for improving the tactics of their management. Results. Our date demonstrates that vaginal disbiosis are risk factor for RVVC and leads to more active innate immune system response. |
| first_indexed | 2024-12-12T05:19:26Z |
| format | Article |
| id | doaj.art-7e88a4ca4108454d86d033edfa153222 |
| institution | Directory Open Access Journal |
| issn | 2079-5696 2079-5831 |
| language | Russian |
| last_indexed | 2024-12-12T05:19:26Z |
| publishDate | 2017-06-01 |
| publisher | IP Berlin A.V. |
| record_format | Article |
| series | Гинекология |
| spelling | doaj.art-7e88a4ca4108454d86d033edfa1532222022-12-22T00:36:39ZrusIP Berlin A.V.Гинекология2079-56962079-58312017-06-01193495425757The profile of the expression of the immune response genes in the vagina of women in the complex therapy of recurrent vulvovaginal candidiasisSh M Pogosyan0E A Mezhevitinova1P R Abakarova2A E Donnikov3V V Muravyova4V.I.Kulakov Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian FederationV.I.Kulakov Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian FederationV.I.Kulakov Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian FederationV.I.Kulakov Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian FederationV.I.Kulakov Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian FederationHost immunity against Candida albicans is crucial in controlling C. albicans infection. The innate immunity is believed to be the first line of host defense, such as the direct killing of yeasts through phagocytosis by neutrophils and macrophages. In addition to innate immune cells, an adjunctive protective effect is played by cellular adaptive immunity represented by Th lymphocytes. The balance of various Th cell subpopulations plays a crucial role in regulating the prognosis of C. albicans infection. Yeasts cell recognition by pattern recognition receptors leads to proinflammatory cytokines synthesis, cause immune system activation and yeast cells killing. However it was demonstrated that C. albicans inhibits immune response which cause infection. Aim - studying vaginal microbiota and the local immune response in women with recurrent vulvovaginal candidiasis for improving the tactics of their management. Results. Our date demonstrates that vaginal disbiosis are risk factor for RVVC and leads to more active innate immune system response.https://gynecology.orscience.ru/2079-5831/article/viewFile/28627/pdfvulvovaginal candidiasisrecurrent vulvovaginal candidiasistreatment of vulvovaginal candidiasisimmune response to vulvovaginal candidiasisgenes expression profile during vulvovaginal candidiasis |
| spellingShingle | Sh M Pogosyan E A Mezhevitinova P R Abakarova A E Donnikov V V Muravyova The profile of the expression of the immune response genes in the vagina of women in the complex therapy of recurrent vulvovaginal candidiasis Гинекология vulvovaginal candidiasis recurrent vulvovaginal candidiasis treatment of vulvovaginal candidiasis immune response to vulvovaginal candidiasis genes expression profile during vulvovaginal candidiasis |
| title | The profile of the expression of the immune response genes in the vagina of women in the complex therapy of recurrent vulvovaginal candidiasis |
| title_full | The profile of the expression of the immune response genes in the vagina of women in the complex therapy of recurrent vulvovaginal candidiasis |
| title_fullStr | The profile of the expression of the immune response genes in the vagina of women in the complex therapy of recurrent vulvovaginal candidiasis |
| title_full_unstemmed | The profile of the expression of the immune response genes in the vagina of women in the complex therapy of recurrent vulvovaginal candidiasis |
| title_short | The profile of the expression of the immune response genes in the vagina of women in the complex therapy of recurrent vulvovaginal candidiasis |
| title_sort | profile of the expression of the immune response genes in the vagina of women in the complex therapy of recurrent vulvovaginal candidiasis |
| topic | vulvovaginal candidiasis recurrent vulvovaginal candidiasis treatment of vulvovaginal candidiasis immune response to vulvovaginal candidiasis genes expression profile during vulvovaginal candidiasis |
| url | https://gynecology.orscience.ru/2079-5831/article/viewFile/28627/pdf |
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