The dopamine neuron synaptic map in the striatum
Summary: Dopamine neurons project to the striatum to control movement, cognition, and motivation via slower volume transmission as well as faster dopamine, glutamate, and GABA synaptic actions capable of conveying the temporal information in dopamine neuron firing. To define the scope of these synap...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124723002152 |
| _version_ | 1811160816935763968 |
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| author | Nao Chuhma Soo Jung Oh Stephen Rayport |
| author_facet | Nao Chuhma Soo Jung Oh Stephen Rayport |
| author_sort | Nao Chuhma |
| collection | DOAJ |
| description | Summary: Dopamine neurons project to the striatum to control movement, cognition, and motivation via slower volume transmission as well as faster dopamine, glutamate, and GABA synaptic actions capable of conveying the temporal information in dopamine neuron firing. To define the scope of these synaptic actions, recordings of dopamine-neuron-evoked synaptic currents were made in four major striatal neuron types, spanning the entire striatum. This revealed that inhibitory postsynaptic currents are widespread, while excitatory postsynaptic currents are localized to the medial nucleus accumbens and the anterolateral-dorsal striatum, and that all synaptic actions are weak in the posterior striatum. Synaptic actions in cholinergic interneurons are the strongest, variably mediating inhibition throughout the striatum and excitation in the medial accumbens, capable of controlling their activity. This mapping shows that dopamine neuron synaptic actions extend throughout the striatum, preferentially target cholinergic interneurons, and define distinct striatal subregions. |
| first_indexed | 2024-04-10T06:04:51Z |
| format | Article |
| id | doaj.art-7e8d646dbbf7439e958f9795c6c8203a |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-04-10T06:04:51Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-7e8d646dbbf7439e958f9795c6c8203a2023-03-03T04:24:29ZengElsevierCell Reports2211-12472023-03-01423112204The dopamine neuron synaptic map in the striatumNao Chuhma0Soo Jung Oh1Stephen Rayport2Department of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032, USA; Department of Psychiatry, Columbia University, New York, NY 10032, USA; Corresponding authorDepartment of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032, USA; Department of Psychiatry, Columbia University, New York, NY 10032, USADepartment of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032, USA; Department of Psychiatry, Columbia University, New York, NY 10032, USA; Corresponding authorSummary: Dopamine neurons project to the striatum to control movement, cognition, and motivation via slower volume transmission as well as faster dopamine, glutamate, and GABA synaptic actions capable of conveying the temporal information in dopamine neuron firing. To define the scope of these synaptic actions, recordings of dopamine-neuron-evoked synaptic currents were made in four major striatal neuron types, spanning the entire striatum. This revealed that inhibitory postsynaptic currents are widespread, while excitatory postsynaptic currents are localized to the medial nucleus accumbens and the anterolateral-dorsal striatum, and that all synaptic actions are weak in the posterior striatum. Synaptic actions in cholinergic interneurons are the strongest, variably mediating inhibition throughout the striatum and excitation in the medial accumbens, capable of controlling their activity. This mapping shows that dopamine neuron synaptic actions extend throughout the striatum, preferentially target cholinergic interneurons, and define distinct striatal subregions.http://www.sciencedirect.com/science/article/pii/S2211124723002152CP: Neuroscience |
| spellingShingle | Nao Chuhma Soo Jung Oh Stephen Rayport The dopamine neuron synaptic map in the striatum Cell Reports CP: Neuroscience |
| title | The dopamine neuron synaptic map in the striatum |
| title_full | The dopamine neuron synaptic map in the striatum |
| title_fullStr | The dopamine neuron synaptic map in the striatum |
| title_full_unstemmed | The dopamine neuron synaptic map in the striatum |
| title_short | The dopamine neuron synaptic map in the striatum |
| title_sort | dopamine neuron synaptic map in the striatum |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124723002152 |
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