Intestinal failure: a review [version 1; referees: 2 approved]
Intestinal failure (IF) is the inability of the gut to absorb necessary water, macronutrients (carbohydrate, protein, and fat), micronutrients, and electrolytes sufficient to sustain life and requiring intravenous supplementation or replacement. Acute IF (types 1 and 2) is the initial phase of the i...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2018-01-01
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| Series: | F1000Research |
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| Online Access: | https://f1000research.com/articles/7-85/v1 |
| _version_ | 1818879766705471488 |
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| author | Philip Allan Simon Lal |
| author_facet | Philip Allan Simon Lal |
| author_sort | Philip Allan |
| collection | DOAJ |
| description | Intestinal failure (IF) is the inability of the gut to absorb necessary water, macronutrients (carbohydrate, protein, and fat), micronutrients, and electrolytes sufficient to sustain life and requiring intravenous supplementation or replacement. Acute IF (types 1 and 2) is the initial phase of the illness and may last for weeks to a few months, and chronic IF (type 3) from months to years. The challenge of caring for patients with IF is not merely the management of the underlying condition leading to IF or the correct provision of appropriate nutrition or both but also the prevention of complications, whether thromboembolic phenomenon (for example, venous occlusion), central venous catheter-related bloodstream infection, IF-associated liver disease, or metabolic bone disease. This review looks at recent questions regarding chronic IF (type 3), its diagnosis and management, the role of the multidisciplinary team, and novel therapies, including hormonal treatment for short bowel syndrome but also surgical options for intestinal lengthening and intestinal transplant. |
| first_indexed | 2024-12-19T14:35:18Z |
| format | Article |
| id | doaj.art-7e8f88956abc490b9d670381d4939a60 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-19T14:35:18Z |
| publishDate | 2018-01-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-7e8f88956abc490b9d670381d4939a602022-12-21T20:17:17ZengF1000 Research LtdF1000Research2046-14022018-01-01710.12688/f1000research.12493.113527Intestinal failure: a review [version 1; referees: 2 approved]Philip Allan0Simon Lal1Translational Gastroenterology Department, University Hospitals Oxford NHS Foundation Trust, Oxford, UKIntestinal Failure Unit, Salford Royal Foundation Trust, Salford, UKIntestinal failure (IF) is the inability of the gut to absorb necessary water, macronutrients (carbohydrate, protein, and fat), micronutrients, and electrolytes sufficient to sustain life and requiring intravenous supplementation or replacement. Acute IF (types 1 and 2) is the initial phase of the illness and may last for weeks to a few months, and chronic IF (type 3) from months to years. The challenge of caring for patients with IF is not merely the management of the underlying condition leading to IF or the correct provision of appropriate nutrition or both but also the prevention of complications, whether thromboembolic phenomenon (for example, venous occlusion), central venous catheter-related bloodstream infection, IF-associated liver disease, or metabolic bone disease. This review looks at recent questions regarding chronic IF (type 3), its diagnosis and management, the role of the multidisciplinary team, and novel therapies, including hormonal treatment for short bowel syndrome but also surgical options for intestinal lengthening and intestinal transplant.https://f1000research.com/articles/7-85/v1Small Intestine |
| spellingShingle | Philip Allan Simon Lal Intestinal failure: a review [version 1; referees: 2 approved] F1000Research Small Intestine |
| title | Intestinal failure: a review [version 1; referees: 2 approved] |
| title_full | Intestinal failure: a review [version 1; referees: 2 approved] |
| title_fullStr | Intestinal failure: a review [version 1; referees: 2 approved] |
| title_full_unstemmed | Intestinal failure: a review [version 1; referees: 2 approved] |
| title_short | Intestinal failure: a review [version 1; referees: 2 approved] |
| title_sort | intestinal failure a review version 1 referees 2 approved |
| topic | Small Intestine |
| url | https://f1000research.com/articles/7-85/v1 |
| work_keys_str_mv | AT philipallan intestinalfailureareviewversion1referees2approved AT simonlal intestinalfailureareviewversion1referees2approved |