Prognostic Role of Serum Lactate Dehydrogenase in Patients With Urothelial Carcinoma: A Systematic Review and Meta-Analysis
Background: To investigate the potential prognostic role of serum lactate dehydrogenase (LDH) in patients with urothelial carcinoma (UC) using the method of systematic review and meta-analysis.Materials and Methods: We searched PubMed, Embase, Cochrane Library, and Web of Science for eligible studie...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-05-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2020.00677/full |
| _version_ | 1819092952650088448 |
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| author | Minhong Wu Pengxiu Lin Lifang Xu Zhiling Yu Qingsheng Chen Hongyong Gu Cailing Liu |
| author_facet | Minhong Wu Pengxiu Lin Lifang Xu Zhiling Yu Qingsheng Chen Hongyong Gu Cailing Liu |
| author_sort | Minhong Wu |
| collection | DOAJ |
| description | Background: To investigate the potential prognostic role of serum lactate dehydrogenase (LDH) in patients with urothelial carcinoma (UC) using the method of systematic review and meta-analysis.Materials and Methods: We searched PubMed, Embase, Cochrane Library, and Web of Science for eligible studies up to February 2020. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were used to estimate the relationship.Results: A total of 14 studies including 4,009 patients with UC were incorporated. The results showed that a high pretreatment serum LDH was associated with an inferior overall survival (OS, HR 1.61, 95% CI 1.39–1.87, p < 0.001), cancer-specific survival (CSS, HR 1.41, 95% CI 1.05–1.90, p = 0.022), and disease-free survival (DFS, HR 1.64, 95% CI 1.04–2.59, p = 0.034) in UC. Subgroup analyses identified that a high pretreatment serum LDH was associated with a poor OS (HR 1.97, 95% CI 1.02–3.81, p = 0.042) and DFS (HR 1.64, 95% CI 1.04–2.59, p = 0.034) in upper tract urothelial carcinoma, a short OS (HR 1.71, 95% CI 1.37–2.15, p < 0.001) in urothelial carcinoma of bladder.Conclusion: Our findings indicated that a high level of pretreatment serum LDH was associated with inferior OS, CSS, and DFS in patients with UC. This biomarker can be an important factor incorporated into the prognostic models for UC. |
| first_indexed | 2024-12-21T23:03:48Z |
| format | Article |
| id | doaj.art-7e91609d66ff44d2a2c2819b55904241 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-21T23:03:48Z |
| publishDate | 2020-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-7e91609d66ff44d2a2c2819b559042412022-12-21T18:47:14ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-05-011010.3389/fonc.2020.00677526409Prognostic Role of Serum Lactate Dehydrogenase in Patients With Urothelial Carcinoma: A Systematic Review and Meta-AnalysisMinhong Wu0Pengxiu Lin1Lifang Xu2Zhiling Yu3Qingsheng Chen4Hongyong Gu5Cailing Liu6Department of Urology, Yichun People's Hospital, Yichun, ChinaDepartment of Urology, Yichun People's Hospital, Yichun, ChinaDepartment of Medical Record Management, Chinese Air Force Specialty Medical Center, Beijing, ChinaDepartment of Urology, Yichun People's Hospital, Yichun, ChinaDepartment of Urology, Yichun People's Hospital, Yichun, ChinaDepartment of Urology, Yichun People's Hospital, Yichun, ChinaDepartment of Urology, Yichun People's Hospital, Yichun, ChinaBackground: To investigate the potential prognostic role of serum lactate dehydrogenase (LDH) in patients with urothelial carcinoma (UC) using the method of systematic review and meta-analysis.Materials and Methods: We searched PubMed, Embase, Cochrane Library, and Web of Science for eligible studies up to February 2020. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were used to estimate the relationship.Results: A total of 14 studies including 4,009 patients with UC were incorporated. The results showed that a high pretreatment serum LDH was associated with an inferior overall survival (OS, HR 1.61, 95% CI 1.39–1.87, p < 0.001), cancer-specific survival (CSS, HR 1.41, 95% CI 1.05–1.90, p = 0.022), and disease-free survival (DFS, HR 1.64, 95% CI 1.04–2.59, p = 0.034) in UC. Subgroup analyses identified that a high pretreatment serum LDH was associated with a poor OS (HR 1.97, 95% CI 1.02–3.81, p = 0.042) and DFS (HR 1.64, 95% CI 1.04–2.59, p = 0.034) in upper tract urothelial carcinoma, a short OS (HR 1.71, 95% CI 1.37–2.15, p < 0.001) in urothelial carcinoma of bladder.Conclusion: Our findings indicated that a high level of pretreatment serum LDH was associated with inferior OS, CSS, and DFS in patients with UC. This biomarker can be an important factor incorporated into the prognostic models for UC.https://www.frontiersin.org/article/10.3389/fonc.2020.00677/fullurothelial carcinomalactate dehydrogenaseprognosissystematic reviewmeta-analysis |
| spellingShingle | Minhong Wu Pengxiu Lin Lifang Xu Zhiling Yu Qingsheng Chen Hongyong Gu Cailing Liu Prognostic Role of Serum Lactate Dehydrogenase in Patients With Urothelial Carcinoma: A Systematic Review and Meta-Analysis Frontiers in Oncology urothelial carcinoma lactate dehydrogenase prognosis systematic review meta-analysis |
| title | Prognostic Role of Serum Lactate Dehydrogenase in Patients With Urothelial Carcinoma: A Systematic Review and Meta-Analysis |
| title_full | Prognostic Role of Serum Lactate Dehydrogenase in Patients With Urothelial Carcinoma: A Systematic Review and Meta-Analysis |
| title_fullStr | Prognostic Role of Serum Lactate Dehydrogenase in Patients With Urothelial Carcinoma: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Prognostic Role of Serum Lactate Dehydrogenase in Patients With Urothelial Carcinoma: A Systematic Review and Meta-Analysis |
| title_short | Prognostic Role of Serum Lactate Dehydrogenase in Patients With Urothelial Carcinoma: A Systematic Review and Meta-Analysis |
| title_sort | prognostic role of serum lactate dehydrogenase in patients with urothelial carcinoma a systematic review and meta analysis |
| topic | urothelial carcinoma lactate dehydrogenase prognosis systematic review meta-analysis |
| url | https://www.frontiersin.org/article/10.3389/fonc.2020.00677/full |
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