Novel Concepts in Systemic Sclerosis Pathogenesis: Role for miRNAs
Systemic sclerosis (SSc) is a rare connective tissue disease with heterogeneous clinical phenotypes. It is characterized by the pathogenic triad: microangiopathy, immune dysfunction, and fibrosis. Epigenetic mechanisms modulate gene expression without interfering with the DNA sequence. Epigenetic ma...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/10/1471 |
| _version_ | 1797515226037354496 |
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| author | Iulia Szabo Laura Muntean Tania Crisan Voicu Rednic Claudia Sirbe Simona Rednic |
| author_facet | Iulia Szabo Laura Muntean Tania Crisan Voicu Rednic Claudia Sirbe Simona Rednic |
| author_sort | Iulia Szabo |
| collection | DOAJ |
| description | Systemic sclerosis (SSc) is a rare connective tissue disease with heterogeneous clinical phenotypes. It is characterized by the pathogenic triad: microangiopathy, immune dysfunction, and fibrosis. Epigenetic mechanisms modulate gene expression without interfering with the DNA sequence. Epigenetic marks may be reversible and their differential response to external stimuli could explain the protean clinical manifestations of SSc while offering the opportunity of targeted drug development. Small, non-coding RNA sequences (miRNAs) have demonstrated complex interactions between vasculature, immune activation, and extracellular matrices. Distinct miRNA profiles were identified in SSc skin specimens and blood samples containing a wide variety of dysregulated miRNAs. Their target genes are mainly involved in profibrotic pathways, but new lines of evidence also confirm their participation in impaired angiogenesis and aberrant immune responses. Research approaches focusing on earlier stages of the disease and on differential miRNA expression in various tissues could bring novel insights into SSc pathogenesis and validate the clinical utility of miRNAs as biomarkers and therapeutic targets. |
| first_indexed | 2024-03-10T06:42:31Z |
| format | Article |
| id | doaj.art-7e91b423c7084f8b878707f3120a7361 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T06:42:31Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-7e91b423c7084f8b878707f3120a73612023-11-22T17:32:25ZengMDPI AGBiomedicines2227-90592021-10-01910147110.3390/biomedicines9101471Novel Concepts in Systemic Sclerosis Pathogenesis: Role for miRNAsIulia Szabo0Laura Muntean1Tania Crisan2Voicu Rednic3Claudia Sirbe4Simona Rednic5Department of Rheumatology, “Iuliu Hațieganu” University of Medicine and Pharmacy Cluj-Napoca, 400000 Cluj-Napoca, RomaniaDepartment of Rheumatology, “Iuliu Hațieganu” University of Medicine and Pharmacy Cluj-Napoca, 400000 Cluj-Napoca, RomaniaDepartment of Medical Genetics, “Iuliu Hațieganu” University of Medicine and Pharmacy Cluj-Napoca, 400000 Cluj-Napoca, RomaniaDepartment of Gastroenterology, “Iuliu Hațieganu” University of Medicine and Pharmacy Cluj-Napoca, 400000 Cluj-Napoca, RomaniaDepartment of Rheumatology, “Iuliu Hațieganu” University of Medicine and Pharmacy Cluj-Napoca, 400000 Cluj-Napoca, RomaniaDepartment of Rheumatology, “Iuliu Hațieganu” University of Medicine and Pharmacy Cluj-Napoca, 400000 Cluj-Napoca, RomaniaSystemic sclerosis (SSc) is a rare connective tissue disease with heterogeneous clinical phenotypes. It is characterized by the pathogenic triad: microangiopathy, immune dysfunction, and fibrosis. Epigenetic mechanisms modulate gene expression without interfering with the DNA sequence. Epigenetic marks may be reversible and their differential response to external stimuli could explain the protean clinical manifestations of SSc while offering the opportunity of targeted drug development. Small, non-coding RNA sequences (miRNAs) have demonstrated complex interactions between vasculature, immune activation, and extracellular matrices. Distinct miRNA profiles were identified in SSc skin specimens and blood samples containing a wide variety of dysregulated miRNAs. Their target genes are mainly involved in profibrotic pathways, but new lines of evidence also confirm their participation in impaired angiogenesis and aberrant immune responses. Research approaches focusing on earlier stages of the disease and on differential miRNA expression in various tissues could bring novel insights into SSc pathogenesis and validate the clinical utility of miRNAs as biomarkers and therapeutic targets.https://www.mdpi.com/2227-9059/9/10/1471systemic sclerosispathogenesisepigenetic mechanismsmiRNAs |
| spellingShingle | Iulia Szabo Laura Muntean Tania Crisan Voicu Rednic Claudia Sirbe Simona Rednic Novel Concepts in Systemic Sclerosis Pathogenesis: Role for miRNAs Biomedicines systemic sclerosis pathogenesis epigenetic mechanisms miRNAs |
| title | Novel Concepts in Systemic Sclerosis Pathogenesis: Role for miRNAs |
| title_full | Novel Concepts in Systemic Sclerosis Pathogenesis: Role for miRNAs |
| title_fullStr | Novel Concepts in Systemic Sclerosis Pathogenesis: Role for miRNAs |
| title_full_unstemmed | Novel Concepts in Systemic Sclerosis Pathogenesis: Role for miRNAs |
| title_short | Novel Concepts in Systemic Sclerosis Pathogenesis: Role for miRNAs |
| title_sort | novel concepts in systemic sclerosis pathogenesis role for mirnas |
| topic | systemic sclerosis pathogenesis epigenetic mechanisms miRNAs |
| url | https://www.mdpi.com/2227-9059/9/10/1471 |
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