Executive Function in Fragile X Syndrome: A Systematic Review
Executive function (EF) supports goal-directed behavior and includes key aspects such as working memory, inhibitory control, cognitive flexibility, attention, processing speed, and planning. Fragile X syndrome (FXS) is the leading inherited monogenic cause of intellectual disability and is phenotypi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-01-01
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| Series: | Brain Sciences |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2076-3425/9/1/15 |
| _version_ | 1818154075842150400 |
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| author | Lauren M. Schmitt Rebecca C. Shaffer David Hessl Craig Erickson |
| author_facet | Lauren M. Schmitt Rebecca C. Shaffer David Hessl Craig Erickson |
| author_sort | Lauren M. Schmitt |
| collection | DOAJ |
| description | Executive function (EF) supports goal-directed behavior and includes key aspects such as working memory, inhibitory control, cognitive flexibility, attention, processing speed, and planning. Fragile X syndrome (FXS) is the leading inherited monogenic cause of intellectual disability and is phenotypically characterized by EF deficits beyond what is expected given general cognitive impairments. Yet, a systematic review of behavioral studies using performance-based measures is needed to provide a summary of EF deficits across domains in males and females with FXS, discuss clinical and biological correlates of these EF deficits, identify critical limitations in available research, and offer suggestions for future studies in this area. Ultimately, this review aims to advance our understanding of the underlying pathophysiological mechanisms contributing to EF in FXS and to inform the development of outcome measures of EF and identification of new treatment targets in FXS. |
| first_indexed | 2024-12-11T14:20:45Z |
| format | Article |
| id | doaj.art-7e9261c758874153a3bede3fdb83e32c |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-12-11T14:20:45Z |
| publishDate | 2019-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-7e9261c758874153a3bede3fdb83e32c2022-12-22T01:02:55ZengMDPI AGBrain Sciences2076-34252019-01-01911510.3390/brainsci9010015brainsci9010015Executive Function in Fragile X Syndrome: A Systematic ReviewLauren M. Schmitt0Rebecca C. Shaffer1David Hessl2Craig Erickson3Division of Child and Adolescent Psychiatry, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USADivision of Developmental and Behavioral Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USAMIND Institute, Department of Psychiatry and Behavioral Sciences, University of California, Davis, CA 95616, USADivision of Child and Adolescent Psychiatry, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USAExecutive function (EF) supports goal-directed behavior and includes key aspects such as working memory, inhibitory control, cognitive flexibility, attention, processing speed, and planning. Fragile X syndrome (FXS) is the leading inherited monogenic cause of intellectual disability and is phenotypically characterized by EF deficits beyond what is expected given general cognitive impairments. Yet, a systematic review of behavioral studies using performance-based measures is needed to provide a summary of EF deficits across domains in males and females with FXS, discuss clinical and biological correlates of these EF deficits, identify critical limitations in available research, and offer suggestions for future studies in this area. Ultimately, this review aims to advance our understanding of the underlying pathophysiological mechanisms contributing to EF in FXS and to inform the development of outcome measures of EF and identification of new treatment targets in FXS.http://www.mdpi.com/2076-3425/9/1/15fragile X syndromeexecutive functionworking memoryset-shiftingcognitive flexibilityinhibitory controlattentionplanningprocessing speed |
| spellingShingle | Lauren M. Schmitt Rebecca C. Shaffer David Hessl Craig Erickson Executive Function in Fragile X Syndrome: A Systematic Review Brain Sciences fragile X syndrome executive function working memory set-shifting cognitive flexibility inhibitory control attention planning processing speed |
| title | Executive Function in Fragile X Syndrome: A Systematic Review |
| title_full | Executive Function in Fragile X Syndrome: A Systematic Review |
| title_fullStr | Executive Function in Fragile X Syndrome: A Systematic Review |
| title_full_unstemmed | Executive Function in Fragile X Syndrome: A Systematic Review |
| title_short | Executive Function in Fragile X Syndrome: A Systematic Review |
| title_sort | executive function in fragile x syndrome a systematic review |
| topic | fragile X syndrome executive function working memory set-shifting cognitive flexibility inhibitory control attention planning processing speed |
| url | http://www.mdpi.com/2076-3425/9/1/15 |
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