Engineered Polymersomes for the Treatment of Fish Odor Syndrome: A First Randomized Double Blind Olfactory Study
Abstract Trimethylamine (TMA) is a metabolite overtly present in patients suffering from trimethylaminuria (TMAU), a rare genetic disorder characterized by a strong “fishy” body odor. To date, no approved pharmacological treatment to sequester excess TMA on the skin of patients exists. Here, transme...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-04-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.201903697 |
| _version_ | 1818497689583616000 |
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| author | Aaron C. Schmidt Erik R. Hebels Charlotte Weitzel Anna Kletzmayr Yinyin Bao Christian Steuer Jean‐Christophe Leroux |
| author_facet | Aaron C. Schmidt Erik R. Hebels Charlotte Weitzel Anna Kletzmayr Yinyin Bao Christian Steuer Jean‐Christophe Leroux |
| author_sort | Aaron C. Schmidt |
| collection | DOAJ |
| description | Abstract Trimethylamine (TMA) is a metabolite overtly present in patients suffering from trimethylaminuria (TMAU), a rare genetic disorder characterized by a strong “fishy” body odor. To date, no approved pharmacological treatment to sequester excess TMA on the skin of patients exists. Here, transmembrane pH gradient poly(isoprene)‐block‐poly(ethylene glycol) (PI‐b‐PEG) polymersomes are investigated for the topical removal of TMA. PI‐b‐PEG amphiphiles of varying chain length are synthesized and evaluated for their ability to form vesicular structures in aqueous media. The optimization of the PI/PEG ratio of transmembrane pH gradient polymersomes allows for the rapid and efficient capture of TMA both in solution and after incorporation into a topical hydrogel matrix at the pH of the skin. A subsequent double blind olfactory study reveals a significant decrease in perceived odor intensity after application of the polymersome‐based formulation on artificial skin substrates that has been incubated in TMA‐containing medium. This simple and novel approach has the potential to ease the burden of people suffering from TMAU. |
| first_indexed | 2024-12-10T18:48:23Z |
| format | Article |
| id | doaj.art-7e9a60f712064193a0f527e7acffb4d6 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-12-10T18:48:23Z |
| publishDate | 2020-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-7e9a60f712064193a0f527e7acffb4d62022-12-22T01:37:25ZengWileyAdvanced Science2198-38442020-04-0178n/an/a10.1002/advs.201903697Engineered Polymersomes for the Treatment of Fish Odor Syndrome: A First Randomized Double Blind Olfactory StudyAaron C. Schmidt0Erik R. Hebels1Charlotte Weitzel2Anna Kletzmayr3Yinyin Bao4Christian Steuer5Jean‐Christophe Leroux6Institute of Pharmaceutical Sciences Department of Chemistry and Applied Biosciences ETH Zurich 8093 Zurich SwitzerlandInstitute of Pharmaceutical Sciences Department of Chemistry and Applied Biosciences ETH Zurich 8093 Zurich SwitzerlandInstitute of Pharmaceutical Sciences Department of Chemistry and Applied Biosciences ETH Zurich 8093 Zurich SwitzerlandInstitute of Pharmaceutical Sciences Department of Chemistry and Applied Biosciences ETH Zurich 8093 Zurich SwitzerlandInstitute of Pharmaceutical Sciences Department of Chemistry and Applied Biosciences ETH Zurich 8093 Zurich SwitzerlandInstitute of Pharmaceutical Sciences Department of Chemistry and Applied Biosciences ETH Zurich 8093 Zurich SwitzerlandInstitute of Pharmaceutical Sciences Department of Chemistry and Applied Biosciences ETH Zurich 8093 Zurich SwitzerlandAbstract Trimethylamine (TMA) is a metabolite overtly present in patients suffering from trimethylaminuria (TMAU), a rare genetic disorder characterized by a strong “fishy” body odor. To date, no approved pharmacological treatment to sequester excess TMA on the skin of patients exists. Here, transmembrane pH gradient poly(isoprene)‐block‐poly(ethylene glycol) (PI‐b‐PEG) polymersomes are investigated for the topical removal of TMA. PI‐b‐PEG amphiphiles of varying chain length are synthesized and evaluated for their ability to form vesicular structures in aqueous media. The optimization of the PI/PEG ratio of transmembrane pH gradient polymersomes allows for the rapid and efficient capture of TMA both in solution and after incorporation into a topical hydrogel matrix at the pH of the skin. A subsequent double blind olfactory study reveals a significant decrease in perceived odor intensity after application of the polymersome‐based formulation on artificial skin substrates that has been incubated in TMA‐containing medium. This simple and novel approach has the potential to ease the burden of people suffering from TMAU.https://doi.org/10.1002/advs.201903697biodetoxificationengineered polymersomesfish odor syndrometrimethylaminetrimethylaminuria |
| spellingShingle | Aaron C. Schmidt Erik R. Hebels Charlotte Weitzel Anna Kletzmayr Yinyin Bao Christian Steuer Jean‐Christophe Leroux Engineered Polymersomes for the Treatment of Fish Odor Syndrome: A First Randomized Double Blind Olfactory Study Advanced Science biodetoxification engineered polymersomes fish odor syndrome trimethylamine trimethylaminuria |
| title | Engineered Polymersomes for the Treatment of Fish Odor Syndrome: A First Randomized Double Blind Olfactory Study |
| title_full | Engineered Polymersomes for the Treatment of Fish Odor Syndrome: A First Randomized Double Blind Olfactory Study |
| title_fullStr | Engineered Polymersomes for the Treatment of Fish Odor Syndrome: A First Randomized Double Blind Olfactory Study |
| title_full_unstemmed | Engineered Polymersomes for the Treatment of Fish Odor Syndrome: A First Randomized Double Blind Olfactory Study |
| title_short | Engineered Polymersomes for the Treatment of Fish Odor Syndrome: A First Randomized Double Blind Olfactory Study |
| title_sort | engineered polymersomes for the treatment of fish odor syndrome a first randomized double blind olfactory study |
| topic | biodetoxification engineered polymersomes fish odor syndrome trimethylamine trimethylaminuria |
| url | https://doi.org/10.1002/advs.201903697 |
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