Quantitative prediction of variant effects on alternative splicing in MAPT using endogenous pre-messenger RNA structure probing

Quantitative prediction of variant effects on alternative splicing in MAPT using endogenous pre-messenger RNA structure probing

Splicing is highly regulated and is modulated by numerous factors. Quantitative predictions for how a mutation will affect precursor mRNA (pre-mRNA) structure and downstream function are particularly challenging. Here, we use a novel chemical probing strategy to visualize endogenous precursor and ma...

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Bibliographic Details
Main Authors: Jayashree Kumar, Lela Lackey, Justin M Waldern, Abhishek Dey, Anthony M Mustoe, Kevin M Weeks, David H Mathews, Alain Laederach
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-06-01
Series:eLife
Subjects:
alternative splicing
beta regression
RNA structural ensemble
Tau
disease variants
chemical structure probing
Online Access:https://elifesciences.org/articles/73888

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