The study of subjective and objective evaluation of sleep disturbances in Parkinson's disease
<strong>Background</strong> Sleep disorder is one of the most common non-motor symptoms in Parkinson's disease (PD) patients. At present, there are subjective and objective tools to evaluate sleep disorders. Nevertheless, previous studies commonly used single subjective questionnair...
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| Format: | Article |
| Language: | English |
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Tianjin Huanhu Hospital
2013-08-01
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| Series: | Chinese Journal of Contemporary Neurology and Neurosurgery |
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| Online Access: | http://www.cjcnn.org/index.php/cjcnn/article/view/786 |
| _version_ | 1828834878749147136 |
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| author | Yan GONG Yu HONG Cheng-jie MAO Wei-dong HU Kang-ping XIONG Yun SHEN Chun-feng LIU |
| author_facet | Yan GONG Yu HONG Cheng-jie MAO Wei-dong HU Kang-ping XIONG Yun SHEN Chun-feng LIU |
| author_sort | Yan GONG |
| collection | DOAJ |
| description | <strong>Background</strong> Sleep disorder is one of the most common non-motor symptoms in Parkinson's disease (PD) patients. At present, there are subjective and objective tools to evaluate sleep disorders. Nevertheless, previous studies commonly used single subjective questionnaires or objective examinations. Therefore, we used the combinations of subjective and objective tools to analyze clinical characteristics of sleep disturbances in PD and investigated differences and consistence between subjective and objective tools. <strong>Methods</strong> One hundred and sixteen PD patients were eligible to participate into this study. All participants were evaluated by Pittsburgh Sleep Quality Index (PSQI), Unified Parkinson's Disease Rating Scale (UPDRS) in "on" condition, Hoehn-Yahr (H-Y) stage, Hamilton Depression Rating Scale (HAMD 24 items), Montreal Cognitive Assessment (MoCA), Epworth Sleepiness Scale (ESS), and underwent a video-polysomnography (Video-PSG). <strong>Results</strong> According to PSQI score of 116 PD patients, the proportion of PD patients with sleep disturbances (PSQI ≥ 7) was 50% (N = 58). Compared to PD patients without sleep disturbances, PD patients with sleep disturbances had lower score of MoCA (23.34 ± 3.50 vs 24.89 ± 3.52; t = 2.377, P = 0.019), higher score of UPDRSⅠ[4.00 (2.00, 5.00) vs 3.00 (2.00, 5.00); U = - 2.306, P = 0.021], UPDRSⅡ[12.00 (9.00, 16.00) vs 10.00 (6.00, 13.00); U = - 1.995, P = 0.046], higher levodopa equivalent daily dose [LED, (508.14 ± 335.85) vs (394.06 ± 236.40) mg/d; t = - 2.115, P = 0.037]. Although PD patients with sleep disturbances had more score of UPDSR Ⅲ and higher H-Y stage, the differences were not significant (P > 0.05). On the other hand, decreased total sleep time (TST), reduced sleep efficiency (SE), increased sleep latency (SL), decreased non-rapid eye movement (NREM) sleep stage Ⅱ time were found for PD patients with sleep disturbances (P < 0.05, for all). Other PSG parameters had no significant differences between PD patients with and without sleep disturbances (P > 0.05, for all). The score of PSQI was positively correlated with the score of ESS (r = 0.200, P = 0.032), HAMD (r = 0.202, P = 0.030), UPDRSⅠ (rs = 0.266, P = 0.004) and Ⅱ (rs = 0.254, P = 0.007), LED (r = 0.213, P = 0.022), SL (rs = 0.211, P = 0.023). Moreover, the score of PSQI was negatively correlated with TST (r = -0.231, P = 0.003), SE (r = -0.192, P = 0.039) and MoCA (r = -0.236, P = 0.011). <strong>Conclusion</strong> PD patients with sleep disturbances had worse cognition impairment, more mood disorders, decreased activity of daily life. Meanwhile, most of PSG parameters were altered in PD patients with sleep disturbances. Moreover, the severity of sleep disturbances in PD patients was correlated with these factors. Overall sleep quality of PD patients assessed with the objective tool could be predicted by the subjective scale. However, to evaluate sleep architecture and other sleep disorders for PD patients, the objective tools (such as Video-PSG monitoring) are necessary to be used. <br /> |
| first_indexed | 2024-12-12T17:48:23Z |
| format | Article |
| id | doaj.art-7e9bfaf742014f7e96fb17c71d85ba4d |
| institution | Directory Open Access Journal |
| issn | 1672-6731 |
| language | English |
| last_indexed | 2024-12-12T17:48:23Z |
| publishDate | 2013-08-01 |
| publisher | Tianjin Huanhu Hospital |
| record_format | Article |
| series | Chinese Journal of Contemporary Neurology and Neurosurgery |
| spelling | doaj.art-7e9bfaf742014f7e96fb17c71d85ba4d2022-12-22T00:16:52ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67312013-08-01138704711785The study of subjective and objective evaluation of sleep disturbances in Parkinson's diseaseYan GONGYu HONGCheng-jie MAOWei-dong HUKang-ping XIONGYun SHENChun-feng LIU<strong>Background</strong> Sleep disorder is one of the most common non-motor symptoms in Parkinson's disease (PD) patients. At present, there are subjective and objective tools to evaluate sleep disorders. Nevertheless, previous studies commonly used single subjective questionnaires or objective examinations. Therefore, we used the combinations of subjective and objective tools to analyze clinical characteristics of sleep disturbances in PD and investigated differences and consistence between subjective and objective tools. <strong>Methods</strong> One hundred and sixteen PD patients were eligible to participate into this study. All participants were evaluated by Pittsburgh Sleep Quality Index (PSQI), Unified Parkinson's Disease Rating Scale (UPDRS) in "on" condition, Hoehn-Yahr (H-Y) stage, Hamilton Depression Rating Scale (HAMD 24 items), Montreal Cognitive Assessment (MoCA), Epworth Sleepiness Scale (ESS), and underwent a video-polysomnography (Video-PSG). <strong>Results</strong> According to PSQI score of 116 PD patients, the proportion of PD patients with sleep disturbances (PSQI ≥ 7) was 50% (N = 58). Compared to PD patients without sleep disturbances, PD patients with sleep disturbances had lower score of MoCA (23.34 ± 3.50 vs 24.89 ± 3.52; t = 2.377, P = 0.019), higher score of UPDRSⅠ[4.00 (2.00, 5.00) vs 3.00 (2.00, 5.00); U = - 2.306, P = 0.021], UPDRSⅡ[12.00 (9.00, 16.00) vs 10.00 (6.00, 13.00); U = - 1.995, P = 0.046], higher levodopa equivalent daily dose [LED, (508.14 ± 335.85) vs (394.06 ± 236.40) mg/d; t = - 2.115, P = 0.037]. Although PD patients with sleep disturbances had more score of UPDSR Ⅲ and higher H-Y stage, the differences were not significant (P > 0.05). On the other hand, decreased total sleep time (TST), reduced sleep efficiency (SE), increased sleep latency (SL), decreased non-rapid eye movement (NREM) sleep stage Ⅱ time were found for PD patients with sleep disturbances (P < 0.05, for all). Other PSG parameters had no significant differences between PD patients with and without sleep disturbances (P > 0.05, for all). The score of PSQI was positively correlated with the score of ESS (r = 0.200, P = 0.032), HAMD (r = 0.202, P = 0.030), UPDRSⅠ (rs = 0.266, P = 0.004) and Ⅱ (rs = 0.254, P = 0.007), LED (r = 0.213, P = 0.022), SL (rs = 0.211, P = 0.023). Moreover, the score of PSQI was negatively correlated with TST (r = -0.231, P = 0.003), SE (r = -0.192, P = 0.039) and MoCA (r = -0.236, P = 0.011). <strong>Conclusion</strong> PD patients with sleep disturbances had worse cognition impairment, more mood disorders, decreased activity of daily life. Meanwhile, most of PSG parameters were altered in PD patients with sleep disturbances. Moreover, the severity of sleep disturbances in PD patients was correlated with these factors. Overall sleep quality of PD patients assessed with the objective tool could be predicted by the subjective scale. However, to evaluate sleep architecture and other sleep disorders for PD patients, the objective tools (such as Video-PSG monitoring) are necessary to be used. <br />http://www.cjcnn.org/index.php/cjcnn/article/view/786Parkinson diseaseSleep disordersNeuropsychological testsPolysomnography |
| spellingShingle | Yan GONG Yu HONG Cheng-jie MAO Wei-dong HU Kang-ping XIONG Yun SHEN Chun-feng LIU The study of subjective and objective evaluation of sleep disturbances in Parkinson's disease Chinese Journal of Contemporary Neurology and Neurosurgery Parkinson disease Sleep disorders Neuropsychological tests Polysomnography |
| title | The study of subjective and objective evaluation of sleep disturbances in Parkinson's disease |
| title_full | The study of subjective and objective evaluation of sleep disturbances in Parkinson's disease |
| title_fullStr | The study of subjective and objective evaluation of sleep disturbances in Parkinson's disease |
| title_full_unstemmed | The study of subjective and objective evaluation of sleep disturbances in Parkinson's disease |
| title_short | The study of subjective and objective evaluation of sleep disturbances in Parkinson's disease |
| title_sort | study of subjective and objective evaluation of sleep disturbances in parkinson s disease |
| topic | Parkinson disease Sleep disorders Neuropsychological tests Polysomnography |
| url | http://www.cjcnn.org/index.php/cjcnn/article/view/786 |
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