On the Role of Central Type-1 Cannabinoid Receptor Gene Regulation in Food Intake and Eating Behaviors
Different neuromodulatory systems are involved in long-term energy balance and body weight and, among these, evidence shows that the endocannabinoid system, in particular the activation of type-1 cannabinoid receptor, plays a key role. We here review current literature focusing on the role of the ge...
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/1/398 |
| _version_ | 1797542611746029568 |
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| author | Mariangela Pucci Elizabeta Zaplatic Maria Vittoria Micioni Di Bonaventura Emanuela Micioni Di Bonaventura Paolo De Cristofaro Mauro Maccarrone Carlo Cifani Claudio D’Addario |
| author_facet | Mariangela Pucci Elizabeta Zaplatic Maria Vittoria Micioni Di Bonaventura Emanuela Micioni Di Bonaventura Paolo De Cristofaro Mauro Maccarrone Carlo Cifani Claudio D’Addario |
| author_sort | Mariangela Pucci |
| collection | DOAJ |
| description | Different neuromodulatory systems are involved in long-term energy balance and body weight and, among these, evidence shows that the endocannabinoid system, in particular the activation of type-1 cannabinoid receptor, plays a key role. We here review current literature focusing on the role of the gene encoding type-1 cannabinoid receptors in the CNS and on the modulation of its expression by food intake and specific eating behaviors. We point out the importance to further investigate how environmental cues might have a role in the development of obesity as well as eating disorders through the transcriptional regulation of this gene in order to prevent or to treat these pathologies. |
| first_indexed | 2024-03-10T13:33:00Z |
| format | Article |
| id | doaj.art-7e9c3a80fc0345559a7827f2b2b573cb |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T13:33:00Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-7e9c3a80fc0345559a7827f2b2b573cb2023-11-21T07:44:44ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-01-0122139810.3390/ijms22010398On the Role of Central Type-1 Cannabinoid Receptor Gene Regulation in Food Intake and Eating BehaviorsMariangela Pucci0Elizabeta Zaplatic1Maria Vittoria Micioni Di Bonaventura2Emanuela Micioni Di Bonaventura3Paolo De Cristofaro4Mauro Maccarrone5Carlo Cifani6Claudio D’Addario7Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo TE, ItalyFaculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo TE, ItalyPharmacology Unit, School of Pharmacy, University of Camerino, 62032 Camerino MC, ItalyPharmacology Unit, School of Pharmacy, University of Camerino, 62032 Camerino MC, ItalyClinical Endocrinology and Metabolism Outpatient Clinic, 64021 Giulianova TE, ItalyDepartment of Biotechnological and Applied Clinical Sciences, University of L’Aquila, 67100 L’Aquila AQ, ItalyPharmacology Unit, School of Pharmacy, University of Camerino, 62032 Camerino MC, ItalyFaculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo TE, ItalyDifferent neuromodulatory systems are involved in long-term energy balance and body weight and, among these, evidence shows that the endocannabinoid system, in particular the activation of type-1 cannabinoid receptor, plays a key role. We here review current literature focusing on the role of the gene encoding type-1 cannabinoid receptors in the CNS and on the modulation of its expression by food intake and specific eating behaviors. We point out the importance to further investigate how environmental cues might have a role in the development of obesity as well as eating disorders through the transcriptional regulation of this gene in order to prevent or to treat these pathologies.https://www.mdpi.com/1422-0067/22/1/398type-1 cannabinoid receptor genetranscriptional regulationfood intakeeating behaviors |
| spellingShingle | Mariangela Pucci Elizabeta Zaplatic Maria Vittoria Micioni Di Bonaventura Emanuela Micioni Di Bonaventura Paolo De Cristofaro Mauro Maccarrone Carlo Cifani Claudio D’Addario On the Role of Central Type-1 Cannabinoid Receptor Gene Regulation in Food Intake and Eating Behaviors International Journal of Molecular Sciences type-1 cannabinoid receptor gene transcriptional regulation food intake eating behaviors |
| title | On the Role of Central Type-1 Cannabinoid Receptor Gene Regulation in Food Intake and Eating Behaviors |
| title_full | On the Role of Central Type-1 Cannabinoid Receptor Gene Regulation in Food Intake and Eating Behaviors |
| title_fullStr | On the Role of Central Type-1 Cannabinoid Receptor Gene Regulation in Food Intake and Eating Behaviors |
| title_full_unstemmed | On the Role of Central Type-1 Cannabinoid Receptor Gene Regulation in Food Intake and Eating Behaviors |
| title_short | On the Role of Central Type-1 Cannabinoid Receptor Gene Regulation in Food Intake and Eating Behaviors |
| title_sort | on the role of central type 1 cannabinoid receptor gene regulation in food intake and eating behaviors |
| topic | type-1 cannabinoid receptor gene transcriptional regulation food intake eating behaviors |
| url | https://www.mdpi.com/1422-0067/22/1/398 |
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