Development of a new scoring method in the neurofunctional assessment of preterm infants
Abstract Infants born preterm are at high risk of presenting neurodevelopmental delay. The Neurofunctional Assessment (NFA) describes infants’ neurodevelopment through the evaluation of six different domains. This study aimed to evaluate how, in a cohort of preterm infants, each NFA domain assessed...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-09-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-20754-y |
| _version_ | 1811236463958818816 |
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| author | Odoardo Picciolini Maria Lorella Giannì Laura Messina Nicola Pesenti Monica Fumagalli Laura Gardon Chiara Squarza Fabio Mosca Camilla Fontana Matteo Porro |
| author_facet | Odoardo Picciolini Maria Lorella Giannì Laura Messina Nicola Pesenti Monica Fumagalli Laura Gardon Chiara Squarza Fabio Mosca Camilla Fontana Matteo Porro |
| author_sort | Odoardo Picciolini |
| collection | DOAJ |
| description | Abstract Infants born preterm are at high risk of presenting neurodevelopmental delay. The Neurofunctional Assessment (NFA) describes infants’ neurodevelopment through the evaluation of six different domains. This study aimed to evaluate how, in a cohort of preterm infants, each NFA domain assessed at 3 months of corrected age (CA) was associated with neurodevelopment at 2 years of CA using the Griffiths Mental Developmental Scales Extended Revised (GMDS-ER). In addition, by introducing the NFA complexity score (CS), the study aimed to define a threshold that can help clinicians discriminate infants at higher risk of later neurodevelopmental delay. We conducted an observational, longitudinal study including 211 preterm infants. At 3 months of CA, infants who had normal scores in each domain showed a significantly higher GMDS-ER global quotient (GQ) at 2 years of CA. In addition, linear model results showed a significant negative relationship between the NFA CS and 2-year GMDS-ER GQ (estimate: − 0.27; 95% CI − 0.35, − 0.20; p value < 0.001). Each 10-point increase in the NFA CS was associated with an average 2.7-point decrease in the GMDS GQ. These results highlight how the NFA domains and NFA CS are compelling instruments for the early identification of children at risk for long-term adverse outcomes. |
| first_indexed | 2024-04-12T12:09:10Z |
| format | Article |
| id | doaj.art-7e9dd9eacccf4073bf10b3da80061859 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T12:09:10Z |
| publishDate | 2022-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-7e9dd9eacccf4073bf10b3da800618592022-12-22T03:33:38ZengNature PortfolioScientific Reports2045-23222022-09-011211810.1038/s41598-022-20754-yDevelopment of a new scoring method in the neurofunctional assessment of preterm infantsOdoardo Picciolini0Maria Lorella Giannì1Laura Messina2Nicola Pesenti3Monica Fumagalli4Laura Gardon5Chiara Squarza6Fabio Mosca7Camilla Fontana8Matteo Porro9Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Pediatric Physical Medicine & Rehabilitation UnitUniversity of Milan, Department of Clinical Sciences and Community HealthFondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Pediatric Physical Medicine & Rehabilitation UnitFondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, NICUUniversity of Milan, Department of Clinical Sciences and Community HealthFondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, NICUFondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, NICUUniversity of Milan, Department of Clinical Sciences and Community HealthFondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, NICUFondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Pediatric Physical Medicine & Rehabilitation UnitAbstract Infants born preterm are at high risk of presenting neurodevelopmental delay. The Neurofunctional Assessment (NFA) describes infants’ neurodevelopment through the evaluation of six different domains. This study aimed to evaluate how, in a cohort of preterm infants, each NFA domain assessed at 3 months of corrected age (CA) was associated with neurodevelopment at 2 years of CA using the Griffiths Mental Developmental Scales Extended Revised (GMDS-ER). In addition, by introducing the NFA complexity score (CS), the study aimed to define a threshold that can help clinicians discriminate infants at higher risk of later neurodevelopmental delay. We conducted an observational, longitudinal study including 211 preterm infants. At 3 months of CA, infants who had normal scores in each domain showed a significantly higher GMDS-ER global quotient (GQ) at 2 years of CA. In addition, linear model results showed a significant negative relationship between the NFA CS and 2-year GMDS-ER GQ (estimate: − 0.27; 95% CI − 0.35, − 0.20; p value < 0.001). Each 10-point increase in the NFA CS was associated with an average 2.7-point decrease in the GMDS GQ. These results highlight how the NFA domains and NFA CS are compelling instruments for the early identification of children at risk for long-term adverse outcomes.https://doi.org/10.1038/s41598-022-20754-y |
| spellingShingle | Odoardo Picciolini Maria Lorella Giannì Laura Messina Nicola Pesenti Monica Fumagalli Laura Gardon Chiara Squarza Fabio Mosca Camilla Fontana Matteo Porro Development of a new scoring method in the neurofunctional assessment of preterm infants Scientific Reports |
| title | Development of a new scoring method in the neurofunctional assessment of preterm infants |
| title_full | Development of a new scoring method in the neurofunctional assessment of preterm infants |
| title_fullStr | Development of a new scoring method in the neurofunctional assessment of preterm infants |
| title_full_unstemmed | Development of a new scoring method in the neurofunctional assessment of preterm infants |
| title_short | Development of a new scoring method in the neurofunctional assessment of preterm infants |
| title_sort | development of a new scoring method in the neurofunctional assessment of preterm infants |
| url | https://doi.org/10.1038/s41598-022-20754-y |
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