Synthesis, Spectroscopic Analysis and Assessment of the Biological Activity of New Hydrazine and Hydrazide Derivatives of 3-Formylchromone
The hydrazine and hydrazide derivatives of benzo-γ-pyrones with fluorine substituents remain an unexplored group of chemical compounds. This preliminary study reports the synthesis, structural assessment, initial microbiological screening and biological testing of the synthesized compounds...
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MDPI AG
2018-08-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/23/8/2067 |
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| author | Krzysztof Słomiak Andrzej Łazarenkow Lilianna Chęcińska Joachim Kusz Justyn Ochocki Jolanta Nawrot-Modranka |
| author_facet | Krzysztof Słomiak Andrzej Łazarenkow Lilianna Chęcińska Joachim Kusz Justyn Ochocki Jolanta Nawrot-Modranka |
| author_sort | Krzysztof Słomiak |
| collection | DOAJ |
| description | The hydrazine and hydrazide derivatives of benzo-γ-pyrones with fluorine substituents remain an unexplored group of chemical compounds. This preliminary study reports the synthesis, structural assessment, initial microbiological screening and biological testing of the synthesized compounds on cell lines using the XTT-assay. A series of 10 novel hydrazine and hydrazide derivatives of 3-formylchromone were synthesized and their structures determined. Structural assessment consisted of elemental analysis, IR, 1H-NMR, 13C-NMR, MS and crystallographic studies. Antimicrobial activity was tested on standard strains representing different groups of microorganisms. The tested compounds were found to inhibit microbial growth. Concentrations of 0.01–1250 µmol/L were found to influence cell proliferation, demonstrating antiproliferative and stimulation of proliferation against two cell lines: the L929 cell line (mouse fibroblast cell line) and the EA.hy926 cell line (the human umbilical vein, somatic cell hybrid). |
| first_indexed | 2024-04-13T02:18:13Z |
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| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-13T02:18:13Z |
| publishDate | 2018-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-7e9def62fe244807ad8c6b0be68e5fd52022-12-22T03:07:04ZengMDPI AGMolecules1420-30492018-08-01238206710.3390/molecules23082067molecules23082067Synthesis, Spectroscopic Analysis and Assessment of the Biological Activity of New Hydrazine and Hydrazide Derivatives of 3-FormylchromoneKrzysztof Słomiak0Andrzej Łazarenkow1Lilianna Chęcińska2Joachim Kusz3Justyn Ochocki4Jolanta Nawrot-Modranka5Department of Bioinorganic Chemistry, Medical University of Lodz, Muszyńskiego 1, 90-151 Łódź, PolandDepartment of Bioinorganic Chemistry, Medical University of Lodz, Muszyńskiego 1, 90-151 Łódź, PolandDepartment of Physical Chemistry, Faculty of Chemistry, University of Lodz, Pomorska 163/165, 90-236 Łódź, PolandDepartment of Physics of Crystals, Institute of Physics, University of Silesia, Uniwersytecka 4, 40-007 Katowice, PolandDepartment of Bioinorganic Chemistry, Medical University of Lodz, Muszyńskiego 1, 90-151 Łódź, PolandDepartment of Bioinorganic Chemistry, Medical University of Lodz, Muszyńskiego 1, 90-151 Łódź, PolandThe hydrazine and hydrazide derivatives of benzo-γ-pyrones with fluorine substituents remain an unexplored group of chemical compounds. This preliminary study reports the synthesis, structural assessment, initial microbiological screening and biological testing of the synthesized compounds on cell lines using the XTT-assay. A series of 10 novel hydrazine and hydrazide derivatives of 3-formylchromone were synthesized and their structures determined. Structural assessment consisted of elemental analysis, IR, 1H-NMR, 13C-NMR, MS and crystallographic studies. Antimicrobial activity was tested on standard strains representing different groups of microorganisms. The tested compounds were found to inhibit microbial growth. Concentrations of 0.01–1250 µmol/L were found to influence cell proliferation, demonstrating antiproliferative and stimulation of proliferation against two cell lines: the L929 cell line (mouse fibroblast cell line) and the EA.hy926 cell line (the human umbilical vein, somatic cell hybrid).http://www.mdpi.com/1420-3049/23/8/2067hydrazinehydrazidebenzo-γ-pyrones3-formylchromoneXTT-assayanti-proliferative activity |
| spellingShingle | Krzysztof Słomiak Andrzej Łazarenkow Lilianna Chęcińska Joachim Kusz Justyn Ochocki Jolanta Nawrot-Modranka Synthesis, Spectroscopic Analysis and Assessment of the Biological Activity of New Hydrazine and Hydrazide Derivatives of 3-Formylchromone Molecules hydrazine hydrazide benzo-γ-pyrones 3-formylchromone XTT-assay anti-proliferative activity |
| title | Synthesis, Spectroscopic Analysis and Assessment of the Biological Activity of New Hydrazine and Hydrazide Derivatives of 3-Formylchromone |
| title_full | Synthesis, Spectroscopic Analysis and Assessment of the Biological Activity of New Hydrazine and Hydrazide Derivatives of 3-Formylchromone |
| title_fullStr | Synthesis, Spectroscopic Analysis and Assessment of the Biological Activity of New Hydrazine and Hydrazide Derivatives of 3-Formylchromone |
| title_full_unstemmed | Synthesis, Spectroscopic Analysis and Assessment of the Biological Activity of New Hydrazine and Hydrazide Derivatives of 3-Formylchromone |
| title_short | Synthesis, Spectroscopic Analysis and Assessment of the Biological Activity of New Hydrazine and Hydrazide Derivatives of 3-Formylchromone |
| title_sort | synthesis spectroscopic analysis and assessment of the biological activity of new hydrazine and hydrazide derivatives of 3 formylchromone |
| topic | hydrazine hydrazide benzo-γ-pyrones 3-formylchromone XTT-assay anti-proliferative activity |
| url | http://www.mdpi.com/1420-3049/23/8/2067 |
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