Case report: Cardiac intimal sarcoma in a young child

Case report: Cardiac intimal sarcoma in a young child

Undifferentiated mesenchymal tumors from the intimal layer (intimal sarcomas) are rare within the ventricles and exceptional in children. A rare case of an intimal sarcoma located in the right ventricle in a young child is presented with need for urgent surgical resection due to mechanical flow obst...

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Bibliographic Details
Main Authors: Sanne Verbeek, Raf Sciot, Maria Debiec-Rychter, Veerle Labarque, Bart Meyns, Bjorn Cools
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Pediatrics
Subjects:
intimal sarcoma
cardiac
child
MDM2
right ventricle (RV)
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2023.1238847/full
Description
Summary:Undifferentiated mesenchymal tumors from the intimal layer (intimal sarcomas) are rare within the ventricles and exceptional in children. A rare case of an intimal sarcoma located in the right ventricle in a young child is presented with need for urgent surgical resection due to mechanical flow obstruction. Tumor cells showed amplification of MDM2 gene and a homozygous loss of CDKN2A on 9p21. A review of the literature regarding primary cardiac malignancies and intimal sarcoma in children is provided.
ISSN:2296-2360

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