Case report: Cardiac intimal sarcoma in a young child
Undifferentiated mesenchymal tumors from the intimal layer (intimal sarcomas) are rare within the ventricles and exceptional in children. A rare case of an intimal sarcoma located in the right ventricle in a young child is presented with need for urgent surgical resection due to mechanical flow obst...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Pediatrics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2023.1238847/full |
| _version_ | 1797674070239608832 |
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| author | Sanne Verbeek Raf Sciot Maria Debiec-Rychter Veerle Labarque Bart Meyns Bjorn Cools |
| author_facet | Sanne Verbeek Raf Sciot Maria Debiec-Rychter Veerle Labarque Bart Meyns Bjorn Cools |
| author_sort | Sanne Verbeek |
| collection | DOAJ |
| description | Undifferentiated mesenchymal tumors from the intimal layer (intimal sarcomas) are rare within the ventricles and exceptional in children. A rare case of an intimal sarcoma located in the right ventricle in a young child is presented with need for urgent surgical resection due to mechanical flow obstruction. Tumor cells showed amplification of MDM2 gene and a homozygous loss of CDKN2A on 9p21. A review of the literature regarding primary cardiac malignancies and intimal sarcoma in children is provided. |
| first_indexed | 2024-03-11T21:54:47Z |
| format | Article |
| id | doaj.art-7e9e32199c234de2a6d0ac50c9d29d36 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-03-11T21:54:47Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-7e9e32199c234de2a6d0ac50c9d29d362023-09-26T04:54:57ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602023-09-011110.3389/fped.2023.12388471238847Case report: Cardiac intimal sarcoma in a young childSanne Verbeek0Raf Sciot1Maria Debiec-Rychter2Veerle Labarque3Bart Meyns4Bjorn Cools5Department of Pathology, University Hospitals Leuven, Leuven, BelgiumDepartment of Pathology, University Hospitals Leuven, Leuven, BelgiumCenter for Human Genetics, Catholic University Leuven, Leuven, BelgiumDepartment of Pediatric Hematology and Oncology, University Hospitals Leuven, Leuven, BelgiumDepartment of Cardiac Surgery, University Hospitals Leuven, Leuven, BelgiumDepartment of Pediatric and Congenital Cardiology, University Hospitals Leuven, Leuven, BelgiumUndifferentiated mesenchymal tumors from the intimal layer (intimal sarcomas) are rare within the ventricles and exceptional in children. A rare case of an intimal sarcoma located in the right ventricle in a young child is presented with need for urgent surgical resection due to mechanical flow obstruction. Tumor cells showed amplification of MDM2 gene and a homozygous loss of CDKN2A on 9p21. A review of the literature regarding primary cardiac malignancies and intimal sarcoma in children is provided.https://www.frontiersin.org/articles/10.3389/fped.2023.1238847/fullintimal sarcomacardiacchildMDM2right ventricle (RV) |
| spellingShingle | Sanne Verbeek Raf Sciot Maria Debiec-Rychter Veerle Labarque Bart Meyns Bjorn Cools Case report: Cardiac intimal sarcoma in a young child Frontiers in Pediatrics intimal sarcoma cardiac child MDM2 right ventricle (RV) |
| title | Case report: Cardiac intimal sarcoma in a young child |
| title_full | Case report: Cardiac intimal sarcoma in a young child |
| title_fullStr | Case report: Cardiac intimal sarcoma in a young child |
| title_full_unstemmed | Case report: Cardiac intimal sarcoma in a young child |
| title_short | Case report: Cardiac intimal sarcoma in a young child |
| title_sort | case report cardiac intimal sarcoma in a young child |
| topic | intimal sarcoma cardiac child MDM2 right ventricle (RV) |
| url | https://www.frontiersin.org/articles/10.3389/fped.2023.1238847/full |
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