Early use of polymyxin B reduces the mortality of carbapenem-resistant Klebsiella pneumoniae bloodstream infection
Polymyxin B is one of the last resort option for carbapenem-resistant Klebsiella pneumoniae (CRKP) bloodstream infection in China. Therefore, the timing of administration of polymyxin is frequently delayed. We collected 40 cases of CRKP bloodstream infections (BSIs) treated with combinations based o...
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| Format: | Article |
| Language: | English |
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Elsevier
2019-01-01
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| Series: | Brazilian Journal of Infectious Diseases |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1413867018306457 |
| _version_ | 1818500466334498816 |
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| author | Qiqiang Liang Man Huang Zhijiang Xu |
| author_facet | Qiqiang Liang Man Huang Zhijiang Xu |
| author_sort | Qiqiang Liang |
| collection | DOAJ |
| description | Polymyxin B is one of the last resort option for carbapenem-resistant Klebsiella pneumoniae (CRKP) bloodstream infection in China. Therefore, the timing of administration of polymyxin is frequently delayed. We collected 40 cases of CRKP bloodstream infections (BSIs) treated with combinations based on polymyxin B over 30 months. The primary outcome, 30-day mortality rate, was 52.5% (21/40). Early administration of polymyxin B is meant to administer the drug within 48 h of diagnosing bacteremia. Delayed administration was considered when polymyxin B was administered after 48 h of bacteremia onset. Polymyxin B duration and total dosages were similar in the two groups (11.57 days versus 11.76 days, p = 0.919; 1306.52 mg versus 1247.06 mg, p = 0.711). Compared with delayed administration, early use of polymyxin B-based combination therapy had a significant increase in the rate of bacterial clearance (65.22% versus 29.41%, p = 0.025; OR = 0.533) and decreased 30-day mortality (39.13% versus 70.59%, p = 0.045; OR = 0.461) and overall mortality (43.48% versus 82.35%, p = 0.022; OR = 0.321). Keywords: carbapenem-resistant Klebsiella pneumoniae bloodstream infection, Polymyxin B-based combination therapy, Drug use timing |
| first_indexed | 2024-12-10T20:43:06Z |
| format | Article |
| id | doaj.art-7e9e4173afea4f44acd04c0e00f8853c |
| institution | Directory Open Access Journal |
| issn | 1413-8670 |
| language | English |
| last_indexed | 2024-12-10T20:43:06Z |
| publishDate | 2019-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-7e9e4173afea4f44acd04c0e00f8853c2022-12-22T01:34:18ZengElsevierBrazilian Journal of Infectious Diseases1413-86702019-01-012316065Early use of polymyxin B reduces the mortality of carbapenem-resistant Klebsiella pneumoniae bloodstream infectionQiqiang Liang0Man Huang1Zhijiang Xu2Second Affiliated Hospital of Zhejiang University, General Intensive Care Unit, Zhejiang, ChinaSecond Affiliated Hospital of Zhejiang University, General Intensive Care Unit, Zhejiang, China; Corresponding author.Second Affiliated Hospital of Zhejiang University, Clinical Laboratory, Zhejiang, ChinaPolymyxin B is one of the last resort option for carbapenem-resistant Klebsiella pneumoniae (CRKP) bloodstream infection in China. Therefore, the timing of administration of polymyxin is frequently delayed. We collected 40 cases of CRKP bloodstream infections (BSIs) treated with combinations based on polymyxin B over 30 months. The primary outcome, 30-day mortality rate, was 52.5% (21/40). Early administration of polymyxin B is meant to administer the drug within 48 h of diagnosing bacteremia. Delayed administration was considered when polymyxin B was administered after 48 h of bacteremia onset. Polymyxin B duration and total dosages were similar in the two groups (11.57 days versus 11.76 days, p = 0.919; 1306.52 mg versus 1247.06 mg, p = 0.711). Compared with delayed administration, early use of polymyxin B-based combination therapy had a significant increase in the rate of bacterial clearance (65.22% versus 29.41%, p = 0.025; OR = 0.533) and decreased 30-day mortality (39.13% versus 70.59%, p = 0.045; OR = 0.461) and overall mortality (43.48% versus 82.35%, p = 0.022; OR = 0.321). Keywords: carbapenem-resistant Klebsiella pneumoniae bloodstream infection, Polymyxin B-based combination therapy, Drug use timinghttp://www.sciencedirect.com/science/article/pii/S1413867018306457 |
| spellingShingle | Qiqiang Liang Man Huang Zhijiang Xu Early use of polymyxin B reduces the mortality of carbapenem-resistant Klebsiella pneumoniae bloodstream infection Brazilian Journal of Infectious Diseases |
| title | Early use of polymyxin B reduces the mortality of carbapenem-resistant Klebsiella pneumoniae bloodstream infection |
| title_full | Early use of polymyxin B reduces the mortality of carbapenem-resistant Klebsiella pneumoniae bloodstream infection |
| title_fullStr | Early use of polymyxin B reduces the mortality of carbapenem-resistant Klebsiella pneumoniae bloodstream infection |
| title_full_unstemmed | Early use of polymyxin B reduces the mortality of carbapenem-resistant Klebsiella pneumoniae bloodstream infection |
| title_short | Early use of polymyxin B reduces the mortality of carbapenem-resistant Klebsiella pneumoniae bloodstream infection |
| title_sort | early use of polymyxin b reduces the mortality of carbapenem resistant klebsiella pneumoniae bloodstream infection |
| url | http://www.sciencedirect.com/science/article/pii/S1413867018306457 |
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