Sensitivity to diazepam after a single session of forced swim stress in weaning Wistar rats
The present study investigated the sensitivity to stress and diazepam in weaning (21-day old) Wistar rats. A single 15-min session of forced swimming was used to induce anxiety-like behavior. The group that was forced to swim exhibited an increase in anxiety-like behavior in the elevated plus maze (...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Sciendo
2018-09-01
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| Series: | Acta Pharmaceutica |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/acph-2018-0027 |
| _version_ | 1818677654670278656 |
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| author | Bernal-Morales Blandina Guillén-Ruiz Gabriel Cueto-Escobedo Jonathan Rodríguez-Landa Juan Francisco Contreras Carlos M. |
| author_facet | Bernal-Morales Blandina Guillén-Ruiz Gabriel Cueto-Escobedo Jonathan Rodríguez-Landa Juan Francisco Contreras Carlos M. |
| author_sort | Bernal-Morales Blandina |
| collection | DOAJ |
| description | The present study investigated the sensitivity to stress and diazepam in weaning (21-day old) Wistar rats. A single 15-min session of forced swimming was used to induce anxiety-like behavior. The group that was forced to swim exhibited an increase in anxiety-like behavior in the elevated plus maze (EPM) and open field test (OFT) compared to the non-stressed group. Diazepam (1 h before the tests) reduced anxiety-like behavior in rats forced to swim compared to the vehicle stressed group. The dose-response curve for diazepam indicated that the 0.5 mg kg−1 dose (1 h before the EPM and OFT) was the minimum effective dose in reducing anxiety-like behavior without altering locomotor activity in weaning rats. These results indicate that weaning rats can develop anxiety-like behavior after a brief, single session of stress, and that rats at this age are seemingly more sensitive to diazepam than adult rats, which may be taken into account for clinical applications. |
| first_indexed | 2024-12-17T09:02:49Z |
| format | Article |
| id | doaj.art-7e9f27999eb545639a356ac0b72020d2 |
| institution | Directory Open Access Journal |
| issn | 1846-9558 |
| language | English |
| last_indexed | 2024-12-17T09:02:49Z |
| publishDate | 2018-09-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj.art-7e9f27999eb545639a356ac0b72020d22022-12-21T21:55:38ZengSciendoActa Pharmaceutica1846-95582018-09-0168338138810.2478/acph-2018-0027acph-2018-0027Sensitivity to diazepam after a single session of forced swim stress in weaning Wistar ratsBernal-Morales Blandina0Guillén-Ruiz Gabriel1Cueto-Escobedo Jonathan2Rodríguez-Landa Juan Francisco3Contreras Carlos M.4Laboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa, MéxicoLaboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa, MéxicoLaboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa, MéxicoLaboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa, MéxicoLaboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa, MéxicoThe present study investigated the sensitivity to stress and diazepam in weaning (21-day old) Wistar rats. A single 15-min session of forced swimming was used to induce anxiety-like behavior. The group that was forced to swim exhibited an increase in anxiety-like behavior in the elevated plus maze (EPM) and open field test (OFT) compared to the non-stressed group. Diazepam (1 h before the tests) reduced anxiety-like behavior in rats forced to swim compared to the vehicle stressed group. The dose-response curve for diazepam indicated that the 0.5 mg kg−1 dose (1 h before the EPM and OFT) was the minimum effective dose in reducing anxiety-like behavior without altering locomotor activity in weaning rats. These results indicate that weaning rats can develop anxiety-like behavior after a brief, single session of stress, and that rats at this age are seemingly more sensitive to diazepam than adult rats, which may be taken into account for clinical applications.https://doi.org/10.2478/acph-2018-0027anxietydiazepamweaning ratselevated plus mazeforced swimopen field test |
| spellingShingle | Bernal-Morales Blandina Guillén-Ruiz Gabriel Cueto-Escobedo Jonathan Rodríguez-Landa Juan Francisco Contreras Carlos M. Sensitivity to diazepam after a single session of forced swim stress in weaning Wistar rats Acta Pharmaceutica anxiety diazepam weaning rats elevated plus maze forced swim open field test |
| title | Sensitivity to diazepam after a single session of forced swim stress in weaning Wistar rats |
| title_full | Sensitivity to diazepam after a single session of forced swim stress in weaning Wistar rats |
| title_fullStr | Sensitivity to diazepam after a single session of forced swim stress in weaning Wistar rats |
| title_full_unstemmed | Sensitivity to diazepam after a single session of forced swim stress in weaning Wistar rats |
| title_short | Sensitivity to diazepam after a single session of forced swim stress in weaning Wistar rats |
| title_sort | sensitivity to diazepam after a single session of forced swim stress in weaning wistar rats |
| topic | anxiety diazepam weaning rats elevated plus maze forced swim open field test |
| url | https://doi.org/10.2478/acph-2018-0027 |
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