Novel Drugs in a Pipeline for Progressive Multiple Sclerosis

Novel Drugs in a Pipeline for Progressive Multiple Sclerosis

Multiple sclerosis (MS) is a widely known inflammatory, demyelinating disease of the central nervous system. The pathogenesis of progressive multiple sclerosis (PMS) is a complex, multi-level process that causes therapeutic difficulties. Along with variables such as age and duration of the disease,...

Full description

Bibliographic Details
Main Authors:	Klaudia Sapko, Anna Jamroz-Wiśniewska, Konrad Rejdak
Format:	Article
Language:	English
Published:	MDPI AG 2022-06-01
Series:	Journal of Clinical Medicine
Subjects:	multiple sclerosis progressive multiple sclerosis neuroprotective drugs remyelinating drugs clinical trials
Online Access:	https://www.mdpi.com/2077-0383/11/12/3342

Similar Items

A metformin add-on clinical study in multiple sclerosis to evaluate brain remyelination and neurodegeneration (MACSiMiSE-BRAIN): study protocol for a multi-center randomized placebo controlled clinical trial
by: Anna-Victoria De Keersmaecker, et al.
Published: (2024-02-01)

Citicoline: A Candidate for Adjunct Treatment of Multiple Sclerosis
by: Paweł Grieb, et al.
Published: (2021-04-01)

The Role of Molecular Imaging as a Marker of Remyelination and Repair in Multiple Sclerosis
by: Ido Ben-Shalom, et al.
Published: (2021-12-01)

Aging, Cellular Senescence, and Progressive Multiple Sclerosis
by: Dimitrios Papadopoulos, et al.
Published: (2020-06-01)

The TOTEM RRMS (Testosterone Treatment on neuroprotection and Myelin Repair in Relapsing Remitting Multiple Sclerosis) trial: study protocol for a randomized, double-blind, placebo-controlled trial
by: Katline Metzger-Peter, et al.
Published: (2020-06-01)

Current requirements for studies of drugs for the pathogenetic treatment of multiple sclerosis
by: A. N. Boyko, et al.
Published: (2019-12-01)

Remyelination Therapy in Multiple Sclerosis
by: Danielle E. Harlow, et al.
Published: (2015-12-01)

Remyelination in Multiple Sclerosis: Findings in the Cuprizone Model
by: Heinig Leo, et al.
Published: (2022-12-01)

Magnetization transfer ratio recovery in new lesions decreases during adolescence in pediatric-onset multiple sclerosis patients
by: Robert A. Brown, et al.
Published: (2014-01-01)

In-vivo characterization of macro- and microstructural injury of the subventricular zone in relapsing-remitting and progressive multiple sclerosis
by: Maria Cellerino, et al.
Published: (2023-04-01)

Progress in the Application of Drugs for the Treatment of Multiple Sclerosis
by: Weipeng Wei, et al.
Published: (2021-07-01)

Advance in new oral drugs for multiple sclerosis
by: Guan⁃en ZHOU, et al.
Published: (2012-04-01)

Development of a sensitive outcome for economical drug screening for progressive multiple sclerosis treatment
by: Peter Kosa, et al.
Published: (2016-08-01)

Estrogen receptor β ligand therapy activates PI3K/Akt/mTOR signaling in oligodendrocytes and promotes remyelination in a mouse model of multiple sclerosis
by: Shalini Kumar, et al.
Published: (2013-08-01)

Oligodendrocyte Development and Regenerative Therapeutics in Multiple Sclerosis
by: Nadjet Gacem, et al.
Published: (2021-04-01)

Deciphering Multiple Sclerosis Progression
by: Virginia Meca-Lallana, et al.
Published: (2021-04-01)

Role of Multifocal Visually Evoked Potential as a Biomarker of Demyelination, Spontaneous Remyelination, and Myelin Repair in Multiple Sclerosis
by: Alexandr Klistorner, et al.
Published: (2021-10-01)

Polarizing receptor activation dissociates fibroblast growth factor 2 mediated inhibition of myelination from its neuroprotective potential
by: Katja Thümmler, et al.
Published: (2019-12-01)

Remyelination in animal models of multiple sclerosis: finding the elusive grail of regeneration
by: Davin Packer, et al.
Published: (2023-06-01)

Clinical markers for unfavorable course of multiple sclerosis
by: Mariya S. Matrosova, et al.
Published: (2023-09-01)

Strategies for Neuroprotection in Multiple Sclerosis and the Role of Calcium
by: Michael Enders, et al.
Published: (2020-02-01)

Microglia in the context of multiple sclerosis
by: Xue Zhang, et al.
Published: (2023-06-01)

The physiology of foamy phagocytes in multiple sclerosis
by: Elien Grajchen, et al.
Published: (2018-11-01)

Vitamin D—An Effective Antioxidant in an Animal Model of Progressive Multiple Sclerosis
by: Michaela Tanja Haindl, et al.
Published: (2023-07-01)

A Review of Herbal Therapy in Multiple Sclerosis
by: Sina Mojaverrostami, et al.
Published: (2018-11-01)

Oligoclonal bands as predictors of multiple sclerosis in clinically isolated syndrome
by: Klaudia Sapko, et al.
Published: (2018-07-01)

Oligoclonal bands as predictors of multiple sclerosis in clinically isolated syndrome
by: Klaudia Sapko, et al.
Published: (2018-07-01)

Myelin Quantification in White Matter Pathology of Progressive Multiple Sclerosis Post-Mortem Brain Samples: A New Approach for Quantifying Remyelination
by: Marije J. D. Huitema, et al.
Published: (2021-11-01)

Neural stem cell engineering for the treatment of multiple sclerosis
by: Tanvir Ahmed
Published: (2022-12-01)

Rehabilitation of patients with progressive forms of multiple sclerosis
by: S. A. Sivertseva, et al.
Published: (2022-08-01)

Motor Behavioral Deficits in the Cuprizone Model: Validity of the Rotarod Test Paradigm
by: Concordia Lubrich, et al.
Published: (2022-09-01)

Changes in retinal structures as markers of multiple sclerosis progression
by: M. O. Poplyak, et al.
Published: (2021-12-01)

Progesterone Enhanced Remyelination in the Mouse Corpus Callosum After Cuprizone Induced Demyelination
by: Iraj Ragerdi Kashani, et al.
Published: (2015-11-01)

Stem Cells Therapy in Multiple Sclerosis - A New Hope for Progressive Forms
by: Ayache SS, et al.
Published: (2016-05-01)

Progress in the diagnosis and treatment of multiple sclerosis
by: Shi-fang HOU, et al.
Published: (2014-10-01)

Treatment Patterns and Unmet Need for Patients with Progressive Multiple Sclerosis in the United States: Survey Results from 2016 to 2021
by: Crystal Watson, et al.
Published: (2023-09-01)

Ultrasound Neuromodulation Reduces Demyelination in a Rat Model of Multiple Sclerosis
by: Feng-Yi Yang, et al.
Published: (2022-09-01)

The complexities of investigating mitochondria dynamics in multiple sclerosis and mouse models of MS
by: Kelley C. Atkinson, et al.
Published: (2023-07-01)

Effects of EHP-101 on inflammation and remyelination in murine models of Multiple sclerosis
by: Carmen Navarrete, et al.
Published: (2020-09-01)

Consensus on early detection of disease progression in patients with multiple sclerosis
by: José E. Meca-Lallana, et al.
Published: (2022-07-01)