Simultaneous Quantification of Anisotropic Microcirculation and Microstructure in Peripheral Nerve
Peripheral nerve injury is a significant public health challenge, and perfusion in the nerve is a potential biomarker for assessing the injury severity and prognostic outlook. Here, we applied a novel formalism that combined intravoxel incoherent motion (IVIM) and diffusion tensor imaging (DTI) to s...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/11/11/3036 |
| _version_ | 1797492904808153088 |
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| author | Samer Merchant Stewart Yeoh Mark A. Mahan Edward W. Hsu |
| author_facet | Samer Merchant Stewart Yeoh Mark A. Mahan Edward W. Hsu |
| author_sort | Samer Merchant |
| collection | DOAJ |
| description | Peripheral nerve injury is a significant public health challenge, and perfusion in the nerve is a potential biomarker for assessing the injury severity and prognostic outlook. Here, we applied a novel formalism that combined intravoxel incoherent motion (IVIM) and diffusion tensor imaging (DTI) to simultaneously characterize anisotropic microcirculation and microstructure in the rat sciatic nerve. Comparison to postmortem measurements revealed that the in vivo IVIM-DTI signal contained a fast compartment (2.32 ± 0.04 × 10<sup>−3</sup> mm<sup>2</sup>/s mean diffusivity, mean ± sem, <i>n</i> = 6, paired <i>t</i> test <i>p</i> < 0.01) that could be attributed to microcirculation in addition to a slower compartment that had similar mean diffusivity as the postmortem nerve (1.04 ± 0.01 vs. 0.96 ± 0.05 × 10<sup>−3</sup> mm<sup>2</sup>/s, <i>p</i> > 0.05). Although further investigation and technical improvement are warranted, this preliminary study demonstrates both the feasibility and potential for applying the IVIM-DTI methodology to peripheral nerves for quantifying perfusion in the presence of anisotropic tissue microstructure. |
| first_indexed | 2024-03-10T01:12:17Z |
| format | Article |
| id | doaj.art-7ea1efaaa4df4061ae7ad7fdf90b0074 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T01:12:17Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-7ea1efaaa4df4061ae7ad7fdf90b00742023-11-23T14:15:44ZengMDPI AGJournal of Clinical Medicine2077-03832022-05-011111303610.3390/jcm11113036Simultaneous Quantification of Anisotropic Microcirculation and Microstructure in Peripheral NerveSamer Merchant0Stewart Yeoh1Mark A. Mahan2Edward W. Hsu3Department of Bioengineering, University of Utah, Salt Lake City, UT 84112, USADepartment of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, UT 84132, USADepartment of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, UT 84132, USADepartment of Bioengineering, University of Utah, Salt Lake City, UT 84112, USAPeripheral nerve injury is a significant public health challenge, and perfusion in the nerve is a potential biomarker for assessing the injury severity and prognostic outlook. Here, we applied a novel formalism that combined intravoxel incoherent motion (IVIM) and diffusion tensor imaging (DTI) to simultaneously characterize anisotropic microcirculation and microstructure in the rat sciatic nerve. Comparison to postmortem measurements revealed that the in vivo IVIM-DTI signal contained a fast compartment (2.32 ± 0.04 × 10<sup>−3</sup> mm<sup>2</sup>/s mean diffusivity, mean ± sem, <i>n</i> = 6, paired <i>t</i> test <i>p</i> < 0.01) that could be attributed to microcirculation in addition to a slower compartment that had similar mean diffusivity as the postmortem nerve (1.04 ± 0.01 vs. 0.96 ± 0.05 × 10<sup>−3</sup> mm<sup>2</sup>/s, <i>p</i> > 0.05). Although further investigation and technical improvement are warranted, this preliminary study demonstrates both the feasibility and potential for applying the IVIM-DTI methodology to peripheral nerves for quantifying perfusion in the presence of anisotropic tissue microstructure.https://www.mdpi.com/2077-0383/11/11/3036DTIIVIMMRIblood flowperfusionnerve |
| spellingShingle | Samer Merchant Stewart Yeoh Mark A. Mahan Edward W. Hsu Simultaneous Quantification of Anisotropic Microcirculation and Microstructure in Peripheral Nerve Journal of Clinical Medicine DTI IVIM MRI blood flow perfusion nerve |
| title | Simultaneous Quantification of Anisotropic Microcirculation and Microstructure in Peripheral Nerve |
| title_full | Simultaneous Quantification of Anisotropic Microcirculation and Microstructure in Peripheral Nerve |
| title_fullStr | Simultaneous Quantification of Anisotropic Microcirculation and Microstructure in Peripheral Nerve |
| title_full_unstemmed | Simultaneous Quantification of Anisotropic Microcirculation and Microstructure in Peripheral Nerve |
| title_short | Simultaneous Quantification of Anisotropic Microcirculation and Microstructure in Peripheral Nerve |
| title_sort | simultaneous quantification of anisotropic microcirculation and microstructure in peripheral nerve |
| topic | DTI IVIM MRI blood flow perfusion nerve |
| url | https://www.mdpi.com/2077-0383/11/11/3036 |
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